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| 1 | The willow genome and divergent evolution from poplar after the common genome duplication显示文摘 | Xiaogang Dai Quanjun Hu Qingle Cai Kai Feng Ning Ye Gerald A Tuskan Richard Milne Yingnan Chen Zhibing Wan Zefu Wang Wenchun Luo Kun Wang Dongshi Wan Mingxiu Wang Jun Wang Jianquan Liu Tongming Yin | 2014 | Cell Research2014，24，10： | 28 |
| 2 | Individualized prostate biopsy strategy for Chinese patients with different prostate-specific antigen levels显示文摘瞄准:为了评估,最好与怀疑的前列腺癌症为中国病人有个性前列腺活体检视策略。方法:现在的学习包括了经历了 transrectal 超声的 221 个中国病人指导前列腺活体检视第一次。所有病人经历了一样的 10 核心活体检视协议。除了农夫六分仪技术,四更多的活体检视从双边的外部地区的基础、中间的区域被获得。在在有特定的 anitgen (PSA ) 铺平的不同前列腺的病人之中的癌症察觉的 10 核心和六分仪策略之间的差别被评估。在 PSA 水平,积极活体检视核心的数字和在前列腺癌症病人的限制器官的癌症率之间的关系也被分析。结果:全面前列腺癌症察觉率在 221 个病人是 40.7% 。10 核心策略增加了癌症在我们的病人的在 6.67% 的察觉(6/90 )(P <
0.05 ) 。当耐心的 PSA 水平从 0-20 ng/mL 增加了到 20.1-50 ng/mL 和 >
时,增加的癌症察觉率显著地减少了 50 ng/mL (P <
0.01 ) 。在前列腺癌症病人的积极活体检视核心的数字与增加耐心的 PSA 水平显著地增加了(P <
0.01 ) 。限制器官的前列腺癌症的率与增加耐心的 PSA 水平显著地减少了(P <
0.01 ) 。结论:扩大 10 核心策略与 PSA 20 ng/mL 为中国病人被推荐,六分仪策略与 PSA >
ng/mL 为那些被推荐。为有从 20.1 ng/mL 到 50 ng/mL 的 PSA 的病人, 10 核心策略应该与预期寿命年在病人被使用,六分仪策略应该与预期寿命 <
在那些被使用 10 年。 | Bo Dai Ding-Wei Ye Yun-Yi Kong Yi-Jin Shen Bo-Hua Wang | 2008 | Asian Journal of Andrology2008，10，2： | 25 |
| 3 | Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy显示文摘AIM To investigate whether patients with refractory epilepsy and healthy infants differ in gut microbiota(GM),and how ketogenic diet(KD) alters GM.METHODS A total of 14 epileptic and 30 healthy infants were recruited and seizure frequencies were recorded. Stool samples were collected for 16 S r DNA sequencing using the Illumina Miseq platform. The composition of GM in each sample was analyzed with MOTHUR,and intergroup comparison was conducted by R software.RESULTS After being on KD treatment for a week,64% of epileptic infants showed an obvious improvement,with a 50% decrease in seizure frequency. GM structure in epileptic infants(P1 group) differed dramatically from that in healthy infants(Health group). Proteobacteria,which had accumulated significantly in the P1 group,decreased dramatically after KD treatment(P2 group). Cronobacter predominated in the P1 group and remained at a low level both in the Health and P2 groups. Bacteroides increased significantly in the P2 group,in which Prevotella and Bifidobacterium also grew in numbers and kept increasing.CONCLUSION GM pattern in healthy infants differed dramatically from that of the epileptic group. KD could significantly modify symptoms of epilepsy and reshape the GM of epileptic infants. | Gan Xie Qian Zhou Chuang-Zhao Qiu Wen-Kui Dai He-Ping Wang Yin-Hu Li Jian-Xiang Liao Xin-Guo Lu Su-Fang Lin Jing-Hua Ye Zhuo-Ya Ma Wen-Jian Wang | 2017 | World Journal of Gastroenterology2017，23，33： | 25 |
| 4 | Involvement of microRNA-21 in mediating chemoresistance to docetaxel in androgen-independent prostate cancer PC3 cells显示文摘 | Guo-hai SHI | 2010 | Acta Pharmacologica Sinica2010，31，7： | 22 |
| 5 | Analysis on Dry Matter Production Characteristics of Super Hybrid Rice显示文摘Six middle-season indica hybrid rice combinations, including five super hybrid rice combinations with the high yield about 10.5 t/ha and a check hybrid rice combination Shanyou 63 with a yield potential about 9.5 t/ha, were used as materials to study the dry matter production characteristics. The super hybrid rice showed a high ability in dry matter production and accumulation and its yield enhanced with the increase of dry matter accumulation. The advantage period of dry matter production in the super hybrid rice was mainly at the middle and late growth stages compared with the check. The grain yield had no significant correlation with the dry matter accumulation before the elongation stage while had a significantly positive correlation with the dry matter accumulation from the elongation to maturity stages in super hybrid rice. There were more dry matter in vegetative organs at the heading stage in the super hybrid rice but its contribution to yield (apparent conversion percentage) was averagely 4.3 percent points lower than that in the check. For crop growth rate (CGR), the comparative advantage of super hybrid rice was at the middle and late stages, especially after flowering. Moreover, as the rising of leaf area index (LAI) and leaf area duration (LAD), CGR enhanced. The total LAD and the mean of LAD per day of super hybrid rice was about 14.79% and 10.31% higher than those of the check, respectively. The results indicate that the high yield of super hybrid rice mostly comes from the products of photosynthesis after heading, which is shown by the increased CGR at middle and later stages. It is suggested that LAD character might be used to better explain the advantage in the dry matter production of super hybrid rice than LAI. | WU Wen-ge ZHANG Hong-cheng QIAN ZHAI Chao-qun DAI Qi-gen Ying-fei CHENG Ye Wu Gui-cheng | 2008 | Rice science2008，15，2： | 16 |
| 6 | Design and Implementation of On-Line Hot Topic Discovery Model显示文摘Internet has become a major medium for information transmission, how to detect hot topic on web, track the event development and forecast emergency is important to many fields, particularly to some government departments. On the basis of the researches in the field of topic detection and tracking, we propose a model for hot topic discovery that will pick out hot topics by automatically detecting, clustering and weighting topics on the websites within a time period. Based on the idea of stock index, we also introduce a topic index approach in following the growth of topics, which is useful to analyze and forecast the development of topics on web. | YE Hui-min CHENG Wei DAI Guan-zhong | 2006 | Wuhan University Journal of Natural Sciences2006，11，1： | 14 |
| 7 | A nomogram to predict Gleason sum upgrading of clinically diagnosed localized prostate cancer among Chinese patients显示文摘Although several models have been developed to predict the probability of Gleason sum upgrading between biopsy and radical prostatectomy specimens,most of these models are restricted to prostatespecific antigen screening-detected prostate cancer.This study aimed to build a nomogram for the prediction of Gleason sum upgrading in clinically diagnosed prostate cancer.The study cohort comprised 269 Chinese prostate cancer patients who underwent prostate biopsy with a minimum of 10 cores and were subsequently treated with radical prostatectomy.Of all included patients,220(81.8%) were referred with clinical symptoms.The prostate-specific antigen level,primary and secondary biopsy Gleason scores,and clinical T category were used in a multivariate logistic regression model to predict the probability of Gleason sum upgrading.The developed nomogram was validated internally.Gleason sum upgrading was observed in 90(33.5%) patients.Our nomogram showed a bootstrap-corrected concordance index of 0.789 and good calibration using 4 readily available variables.The nomogram also demonstrated satisfactory statistical performance for predicting significant upgrading.External validation of the nomogram published by Chun et al.in our cohort showed a marked discordance between the observed and predicted probabilities of Gleason sum upgrading.In summary,a new nomogram to predict Gleason sum upgrading in clinically diagnosed prostate cancer was developed,and it demonstrated good statistical performance upon internal validation. | Jin-You Wang Yao Zhu Chao-Fu Wang Shi-Lin Zhang Bo Dai Ding-Wei Ye | 2014 | Chinese Journal of Cancer2014，33，5： | 13 |
| 8 | Prevalence of incidental prostate cancer in patients undergoing radical cystoprostatectomy: data from China and other Asian countries显示文摘这研究的目的是调查在亚洲在激进的 cystoprostatectomy 标本顺便说一下发现的前列腺癌症(Pca ) 的频率并且为亚洲病人决定前列腺圆材囊切除术(PSC ) 的可行性。在我们在 2003 年 1 月和 2008 年 1 月之间的中心经历了激进的 cystoprostatectomy 的 92 个男膀胱癌症病人在这研究被包括。病人的吝啬的年龄是 67.1 年(范围:32 鈥 ? 5 年) 。前列腺特定的抗原(PSA ) 铺平,在外科回顾地被获得以前,数字直肠的检查(DRE ) 结果。所有病人的前列腺被嵌入并且在 5 公里间隔的 sectioned。一样的病理学家从激进的 cystoprostatectomy 标本检验了 prostatic 纸巾。最后,结构化的文学评论用 MEDLINE 和 PUBMED 被执行在亚洲估计偶然的 Pca 的出现。92 个病人,(3.3%) 3 被发现有 Pca;在从三的(33.3%) 病人疾病由于一个格利森等级是临床上重要的 4 癌。八篇文章在我们的评论被包括。在亚洲在激进的 cystoprostatectomy 标本顺便说一下发现的 Pca 的全面发生是 9.9%(64/642 ) 。当年龄被限制为时 < 60 年,仅仅 7 (3.2%) 从 222,病人们被发现有盒子的同步 Pca,和没有是临床上重要的。在在亚洲的激进的 cystoprostatectomy 标本的 Pca 的出现在西方的国家是比那低得多的。PSC 可能为在一种严格的外科手术前的选择下面的亚洲病人是可行的。 | Yi-Ping Zhu Ding-Wei Ye Xu-Dong Yao Shi-Lin Zhang Bo Dai Hai-Liang Zhang Yi-Jun Shen Yao Zhu Guo-Hai Shi | 2009 | Asian Journal of Andrology2009，11，1： | 12 |
| 9 | Active and passive smoking with breast cancer risk for Chinese females: a systematic review and meta-analysis显示文摘Previous studies suggested that smoking and passive smoking could increase the risk of breast cancer, but the results were inconsistent, especially for Chinese females. Thus, we systematically searched cohort and case-control studies investigating the associations of active and passive smoking with breast cancer risk among Chinese females in four English databases(PubMed, Embase, ScienceDirect, and Wiley) and three Chinese databases(CNKI, WanFang, and VIP). Fifty-one articles(3 cohort studies and 48 casecontrol studies) covering 17 provinces of China were finally included in this systematic review. Among Chinese females, there was significant association between passive smoking and this risk of breast cancer [odds ratio(OR): 1.62; 95% confidence interval(CI): 1.39–1.85; I2 = 75.8%, P < 0.001; n = 26] but no significant association between active smoking and the risk of breast cancer(OR: 1.04; 95% CI: 0.89–1.20; I2 = 13.9%, P = 0.248; n = 31). The OR of exposure to husband's smoking and to smoke in the workplace was 1.27(95% CI: 1.07–1.50) and 1.66(95% CI: 1.07–2.59), respectively. The OR of light and heavy passive smoking was 1.11 and 1.41, respectively, for women exposed to their husband's smoke(< 20 and ≥ 20 cigarettes per day), and 1.07 and 1.87, respectively, for those exposed to smoke in the workplace(< 300 and ≥ 300 min of exposure per day). These results imply that passive smoking is associated with an increased risk of breast cancer, and the risk seems to increase as the level of passive exposure to smoke increases among Chinese females. Women with passive exposure to smoke in the workplace have a higher risk of breast cancer than those exposed to their husband's smoking. | Chuan Chen Yu-Bei Huang Xue-Ou Liu Ying Gao Hong-Ji Dai Feng-Ju Song Wei-Qin Li Jing Wang Ye Yan Pei-Shan Wang Yao-Gang Wang Ke-Xin Chen | 2014 | Chinese Journal of Cancer2014，33，6： | 12 |
| 10 | Discrete Variable Structural Optimization based on Multidirectional Fuzzy Genetic Algorithm显示文摘Round method is the common method for discrete variable optimization in optimal design of complex mechanical structures;however,it has some disadvantages such as poor precision,simple model and lacking of working conditions' description,etc.To solve these problems,a new model is constructed by defining parameterized fuzzy entropy,and the rationality of parameterized fuzzy entropy is verified.And a new multidirectional searching algorithm is further put forward,which takes information of actual working conditions into consideration and has a powerful local searching capability.Then this new algorithm is combined with the GA by the fuzzy clustering algorithm(FCA).With the application of FCA,the optimal solution can be effectively filtered so as to retain the diversity and the elite of the optimal solution,and avoid the structural re-analysis phenomenon between the two algorithms.The structure design of a high pressure bypass-valve body is used as an example to make a structural optimization by the proposed HGA and finite element method(FEM),respectively.The comparison result shows that the improved HGA fully considers the characteristic of discrete variable and information of working conditions,and is more suitable to the optimal problems with complex working conditions.Meanwhile,the research provides a new approach for discrete variable structure optimization problems. | LAI Yinan DAI Ye BAI Xue CHEN Dongyan | 2012 | Chinese Journal of Mechanical Engineering2012，25，2： | 12 |
| 11 | ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma显示文摘Sorafenib is the first-line treatment of advanced hepatocellular carcinoma(HCC).However,there is a lack of validated biomarkers to predict sorafenib sensitivity.In this study we investigated the role of ACSL4,a positive-activating enzyme of ferroptosis,in sorafenib-induced cell death and HCC patient outcome.We showed that ACSL4 protein expression was negatively associated with IC50 values of sorafenib in a panel of HCC cell lines(R=−0.952,P<0.001).Knockdown of ACSL4 expression by specific siRNA/sgRNA significantly attenuated sorafenib-induced lipid peroxidation and ferroptosis in Huh7 cells,and also rescued sorafenib-induced inhibition of xenograft tumor growth in vivo.We selected 29 HCC patients with surgery as primary treatment and sorafenib as postoperative adjunct therapy from a hospital-based cohort.A high proportion(66.7%)of HCC patients who had complete or partial responses to sorafenib treatment(according to the revised RECIST guideline)had higher ACSL4 expression in the pretreated HCC tissues,compared with those who had stable or progressed tumor growth(23.5%,P=0.029).Since ACSL4 expression was independent of sorafenib treatment,it could serve as a useful predictive biomarker.Taken together,this study demonstrates that ACSL4 is essential for sorafenib-induced ferroptosis and useful for predicting sorafenib sensitivity in HCC.This study may have important translational impacts in precise treatment of HCC. | Ji Feng Pei-zhi Lu Guang-zhi Zhu Shing Chung Hooi Yong Wu Xiao-wei Huang Hui-qi Dai Pan-hong Chen Zhong-jie Li Wen-jing Su Chuang-ye Han Xin-ping Ye Tao Peng Jing Zhou Guo-dong Lu | 2021 | Acta Pharmacologica Sinica2021，42，1： | 11 |
| 12 | Inhibitive effects of anti-oxidative vitamins on mannitol-induced apoptosis of vascular endothelial cells显示文摘Objective: Study blood vessel injury and gene expression indicating vascular endothelial cell apoptosis induced by mannitol with and without administration of anti-oxidative vitamins. Methods: Healthy rabbits were randomly divided into four groups. Mannitol was injected into the vein of the rabbit ear in each animal. Pre-treatment prior to mannitol injection was per- formed with normal saline (group B), vitamin C (group C) and vitamin E (group D). Blood vessel injury was assessed under electron and light microscopy. In a second experiment, cell culture specimen of human umbilical vein endothelial cells were treated with mannitol. Pre-treatment was done with normal saline (sample B), vitamin C (sample C) and vitamin E (sample D). Total RNA was extracted with the original single step procedure, followed by hybridisation and analysis of gene expression. Results: In the animal experiment, serious blood vessel injury was seen in group A and group B. Group D showed light injury only, and normal tissue without pathological changes was seen in group C. Of all 330 apoptosis-related genes analysed in human cell culture specimen, no significant difference was seen after pre-treatment with normal saline, compared with the gene chip without pre-treatment. On the gene chip pre-treated with vitamin C, 45 apoptosis genes were down-regulated and 34 anti-apoptosis genes were up-regulated. Pre-treatment with vitamin E resulted in the down-regulation of 3 apoptosis genes. Conclusion: Vitamin C can protect vascular endothelial cells from mannitol-induced injury. | PAN Kai-yu SHEN Mei-ping YE Zhi-hong DAI Xiao-na SHANG Shi-qiang | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，10： | 11 |
| 13 | Relationship between circumcision and human papillomavirus infection: a systematic review and meta-analysis显示文摘男割礼(MC ) 被报导减少人的乳头状瘤病毒(HPV ) 在人的流行。然而,功效仍然保持不精确。这研究的目的是进行系统的评论和元分析估计在 MC 和生殖器的 HPV 感染和生殖器的肉赘之间的关系。科学的 PUBMED, EMBASE,和网从开始被寻找到 2015 年 3 月 22 日。我们识别了 30 份报纸,包括 12149 的一个总数割除并且与生殖器的 HPV 或生殖器的肉赘为割礼的协会被评估的 12252 个异教的人。与是的人相比,没割除的、割除的人可能有生殖器的 HPV 流行的显著地减少的机会(机会比率[或] :0.68;95% 信心间隔[95% CI ] :0.56-0.82 ) 。在 MC 和新感染的生殖器的 HPV 获得之间没有重要协会(或:0.99;95% CI:0.62-1.60 ) ,生殖器的 HPV 清理(或:1.38;95% CI:0.96-1.97 ) ,并且生殖器的肉赘的流行(或:1.17;95% CI:0.63-2.17 ) 。这元分析建议割礼减少生殖器的 HPV 感染的流行。然而,没有清楚的证据被发现那割礼与减少的 HPV 获得被联系,增加的 HPV 清理,或减少生殖器的肉赘的流行。更多的研究被要求足够地在 HPV 感染和生殖器的肉赘的流行的获得和清理上评估 MC 的效果。 | Yi-Ping Zhu Zhong-Wei Jia Bo Dai Ding-Wei Ye Yun-Yi Kong Kun Chang Yue Wang | 2017 | Asian Journal of Andrology2017，19，1： | 11 |
| 14 | Cigarette smoking contributes to idiopathic pulmonary fibrosis associated with emphysema显示文摘 | Ye Qiao Huang Kewu Ding Yi Lou Baohui Hou Ziliang Dai Huaping Wang Chen | 2014 | Chinese Medical Journal2014，，3： | 10 |
| 15 | Effects of Nitrogen Application Levels on Ammonia Volatilization and Nitrogen Utilization during Rice Growing Season显示文摘We conducted field trials of rice grown in sandy soil and clay soil to determine the effects of nitrogen application levels on the concentration of NH4+-N in surface water,loss of ammonia through volatilization from paddy fields,rice production,nitrogen-use efficiency,and nitrogen content in the soil profile.The concentration of NH4+-N in surface water and the amount of ammonia lost through volatilization increased with increasing nitrogen application level,and peaked at 1-3 d after nitrogen application.Less ammonia was lost via volatilization from clay soil than from sandy soil.The amounts of ammonia lost via volatilization after nitrogen application differed depending on the stage when it was applied,from the highest loss to the lowest:N application to promote tillering > the first N topdressing to promote panicle initiation(applied at the last 4-leaf stage) > basal fertilizer > the second N topdressing to promote panicle initiation(applied at the last 2-leaf stage).The total loss of ammonia via volatilization from clay soil was 10.49-87.06 kg/hm2,equivalent to 10.92%-21.76% of the nitrogen applied.The total loss of ammonia via volatilization from sandy soil was 11.32?102.43 kg/hm2,equivalent to 11.32%-25.61% of the nitrogen applied.The amount of ammonia lost via volatilization and the concentration of NH4+-N in surface water peaked simultaneously after nitrogen application;both showed maxima at the tillering stage with the ratio between them ranging from 23.76% to 33.65%.With the increase in nitrogen application level,rice production and nitrogen accumulation in plants increased,but nitrogen-use efficiency decreased.Rice production and nitrogen accumulation in plants were slightly higher in clay soil than in sandy soil.In the soil,the nitrogen content was the lowest at a depth of 40-50 cm.In any specific soil layer,the soil nitrogen content increased with increasing nitrogen application level,and the soil nitrogen content was higher in clay soil than in sandy soil.In terms of ammonia volatilization,the amount of ammonia lost via volatilization increased markedly when the nitrogen application level exceeded 250 kg/hm2 in the rice growing season.However,for rice production,a suitable nitrogen application level is approximately 300 kg/hm2.Therefore,taking the needs for high crop yields and environmental protection into account,the appropriate nitrogen application level was 250-300 kg/hm2 in these conditions. | LIN Zhong-cheng DAI Qi-gen YE Shi-chao WU Fu-guan JIA Yu-shu CHEN Jing-dou XU Lu-sheng ZHANG Hong-cheng Huo Zhong-yang Xu Ke WEt Hai-yan | 2012 | Rice science2012，19，2： | 9 |
| 16 | Fourth C hinese National Consensus Report on the management of H elicobacter pylori infection显示文摘 | Wen Zhong Liu Yong Xie Hong Cheng Nong Hua Lu Fu Lian Hu Wan Dai Zhang Li Ya Zhou Ye Chen Zhi Rong Zeng Chong Wen Wang Shu Dong Xiao Guo Zong Pan Pin Jin Hu | 2013 | Journal of Digestive Diseases2013，，5： | 9 |
| 17 | External validation of the Prostate Cancer Prevention Trial and the European Randomized Study of Screening for Prostate Cancer risk calculators in a Chinese cohort显示文摘几个预言模型被开发了估计前列腺活体检视的结果。大多数这些工具与西方的人口为使用被设计并且没越过不同的种族组被验证。因此,我们评估了前列腺癌症预防审判(PCPT ) 和在一个中国队为前列腺癌症(ERSPC ) 风险计算器屏蔽的欧洲使随机化的学习的预兆的值。Clinicopathological 信息从经历了在 2009 年 1 月和 2011 年 3 月之间的扩大前列腺活体检视的 495 个中国人被获得。前列腺癌症和高级疾病的估计的可能性(格利森 > 6 ) 用 PCPT 和 ERSPC 风险计算器被计算。全面措施,辨别,刻度和临床的实用性为模型评估被估计。这些病人, 28.7 %与前列腺癌症和 19.4 % 被诊断;有的高级疾病。比作 PCPT 模型和 4 的前列腺特定的抗原(PSA ) 阀值; ERSPC 风险计算器展出了的 ng ml −1, 为预言积极活体检视和高级疾病的更好歧视的能力(分别地,在曲线下面的区域是 0.831 和 0.852 P< 0.01 为两个) 。决定曲线分析也在确认数据集建议了 ERSPC 计算器的赞成临床的实用程序。两个预言模型表明了错误刻度:前列腺癌症和高级疾病的风险被约 20 % 过高估计;为大量预言的可能性。在结论, ERSPC 风险计算器超过了 PCPT 模型和 4 的 PSA 阀值;在在中国病人预言前列腺癌症和高级疾病的 ng ml −1 。然而,显著地从西方的人导出的预言工具在一个中国队与活体检视的结果相比过高估计前列腺癌症和高级疾病的概率。 | Yao Zhu Jin-You Wang Yi-Jun Shen Bo Dai Chun-Guang Ma Wen-Jun Xiao Guo-Wen Lin Xu-Dong Yao Shi-Lin Zhang Ding-Wei Ye | 2012 | Asian Journal of Andrology2012，14，5： | 9 |
| 18 | Clinical features and outcomes of 210 patients with idiopathic pulmonary fibrosis显示文摘 | Cai Miaotian Zhu Min Ban Chengjun Su Jin Ye Qiao Liu Yan Zhao Wen Wang Chen Dai Huaping | 2014 | Chinese Medical Journal2014，，10： | 8 |
| 19 | Prognostic factors in Chinese patients with metastatic castration-resistant prostate cancer treated with docetaxel-based chemotherapy显示文摘这研究试图在与与基于 docetaxel 的 thermotherapy 治疗的变形阉割抵抗的前列腺癌症(mCRPC ) 在病人预言全面幸存(OS ) 评估耐心的特征的潜在的价值。有经历 docetaxel q3w 政体的 mCRPC 的 115 个病人的一个总数在这研究被注册。幸存分析用 Kaplan-Meier 方法被执行。考克斯比例的危险模型被用来为 OS 评估所有 covariates 的预示的价值。OS 也在成层以后被分析病人根据 multivariate 分析的结果。为全部队的中部的 OS 是 17.0 个月。multivariate 分析证明前列腺特定的抗原双倍工资(PSADT ) ,基线血色素(Hb ) 集中,碱的磷酸酶(高山) 集中,到阉割抵抗的化疗和时间的周期是 OS 的独立预示的因素。根据 PSADT < 的存在; 46.3 天和基线高山 ≥ 110 IU l −1, 所有病人被划分成三个风险组:低风险的组(没有风险因素) ,中间风险的组(一个风险因素) 和高风险的组(二个风险因素) 。为病人在的中部的 OS 低 -- ,中间风险、高风险的组是 28.0 个月(95 %CI:23.8-32.2 ) , 21.0 个月(95 %CI:18.9-23.1 ) 并且 11.0 个月(95 %CI:7.6-14.4 ) ,分别地(P< 0.001 ) 。在结论, PSADT,基线 Hb 集中,高山集中,到阉割抵抗的化疗和时间的周期是在中国病人的 OS 的独立预示的因素, mCRPC 与 docetaxel 对待。与基线高山集中相结合的 PSADT 能是为评估幸存结果的一个有用风险层化参数。 | Yuan-Yuan | 2013 | Asian Journal of Andrology2013，15，1： | 8 |
| 20 | 骨转移前列腺癌病人升高的血清miR-141水平与增多的骨转移病变数相关显示文摘前列腺癌患者最常见的转移部位是骨骼,因此那些有利于检测和监控骨转移的非创伤性生化指标对于前列腺癌尤为重要。我们设计该研究检测血清miR-141在骨转移前列腺癌患者中的表达情况。我们收集56例患者的血清样本进行miR-141检测,其中包括6例良性前列腺增生症(BPH),20例局限性前列腺癌,30例骨转移前列腺癌(激素未治性前列腺癌10例,激素敏感前列腺癌10例,激素抵抗性前列腺癌10例)。每例前列腺癌患者均行骨扫描检查评估骨转移病变的数量。特异性的TaqMan实时定量RT-PCR用于定量检测血清中的miR-141水平。结果显示,血清miR-141在骨转移患者中的表达升高(P〈0.001)。良性前列腺增生与局限性前列腺癌患者的血清miR-141表达水平无统计学差异。Kendall双变量相关检验显示,Gleason评分和骨转移病灶数目与血清miR-141的表达水平相关(P值分别为0.012和〈0.001)。Pearson双变量相关检验发现碱性磷酸酶(ALP)在骨转移患者中与血清miR-141水平呈正相关。miR-141表达水平与血清前列腺特异性抗原(PSA)表达水平无明确相关性。我们的结论足,血清miR.141的水平在骨转移前列腺癌患者中表达升高;血清miR-141水平越高,骨转移病变的数目越多;此外,血清miR-141的水平与血清ALP水平相关,但与血清PSA水平不相关。 | Hai-Liang Zhang Xiao-Jian Qin Da-Long Cao Yao Zhu Xu-Dong Yao Shi-Lin Zhang Bo Dai Ding-Wei Ye | 2013 | Asian Journal of Andrology2013，15，2： | 7 |
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