|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatitis E virus in patients with acute severe liver injury显示文摘AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit.METHODS: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain reaction.RESULTS: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient died from sepsis and liver failure precipitated as a result of hepatitis E infection and previously undiagnosed cirrhosis. Histopathology data to date is limited to mainly that seen for endemic HepE. All patients, with the exception of patient 1, demonstrated characteristics of HepE infection, as seen in previously described locally acquired cases.CONCLUSION: In patients with acute severe liver injury, HEV testing should be part of the initial diagnostic investigation algorithm irrespective of suspected initial diagnosis, age or travel history. | Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy Janice Davidson Harry R Dalton Linda Scobie | 2014 | World Journal of Hepatology2014，6，6： | 4 |
| 2 | Femtojoule electro-optic modulation using a silicon– organic hybrid device显示文摘Energy-efficient electro-optic modulators are at the heart of short-reach optical interconnects,and silicon photonics is considered the leading technology for realizing such devices.However,the performance of all-silicon devices is limited by intrinsic material properties.In particular,the absence of linear electro-optic effects in silicon renders the integration of energy-efficient photonic–electronic interfaces challenging.Silicon–organic hybrid(SOH)integration can overcome these limitations by combining nanophotonic silicon waveguides with organic cladding materials,thereby offering the prospect of designing optical properties by molecular engineering.In this paper,we demonstrate an SOH Mach–Zehnder modulator with unprecedented efficiency:the 1-mm-long device consumes only 0.7 fJ bit^(-1) to generate a 12.5 Gbit s^(-1) data stream with a bit-error ratio below the threshold for hard-decision forward-error correction.This power consumption represents the lowest value demonstrated for a non-resonant Mach–Zehnder modulator in any material system.It is enabled by a novel class of organic electro-optic materials that are designed for high chromophore density and enhanced molecular orientation.The device features an electro-optic coefficient of r33<180 pm V^(-1) and can be operated at data rates of up to 40 Gbit s^(-1). | Sebastian Koeber Robert Palmer Matthias Lauermann Wolfgang Heni Delwin L Elder Dietmar Korn Markus Woessner Luca Alloatti Swen Koenig Philipp C Schindler Hui Yu Wim Bogaerts Larry R Dalton Wolfgang Freude Juerg Leuthold Christian Koos | 2015 | Light(Science & Applications)2015，4，1： | 4 |
| 3 | Hepatitis E: an emerging infection in developed countries显示文摘 | Harry R Dalton Richard Bendall Samreen Ijaz Malcolm Banks | 2008 | The Lancet Infectious Diseases2008，，11： | 2 |
| 4 | Hepatitis E显示文摘 | Nassim Kamar Richard Bendall Florence Legrand-Abravanel Ning-Shao Xia Samreen Ijaz Jacques Izopet Harry R Dalton | 2012 | The Lancet2012，，9835： | 2 |
| 5 | Hepatitis E in developed countries: current status and future perspectives显示文摘 | Dalton Harry R Kamar Nassim Izopet Jacques | 2014 | Future Microbiology2014，，12： | 2 |
| 6 | Autochthonous hepa- titis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood do- nors, the elderly and patients with chronic liver disease显示文摘 | Dalton H R Stableforth W Thurairajah P | 2008 | Eur J Gastroenterol Hepatol2008，20，8： | 1 |
| 7 | Hepatitis E: an emer-ging infection in developed countries 显示文摘 | Dalton H R Bendall R Ijaz S | 2008 | Lancet Infect Dis2008，，8： | 1 |
| 8 | ACORGA ZNX50- a new selective reagent for the solvent extraction ofzinc from chloride leach solutions显示文摘 | Dalton R F Burgess A Quan P M | 1992 | Hydrometallurgy1992，30，13： | 1 |
| 9 | Can researchers find recipe for proteins and chips? 显示文摘 | Dalton R Abbott A | 1999 | Nature1999，402，6763： | 1 |
| 10 | Micro-scalemeasurement of the mechanical properties of com-pressed pharmaceutical powders (2):The dynamic moduli of microcrystalline cellulose显示文摘 | Dalton C R Clas S-D | 2001 | Int JPharm2001，228，12： | 1 |
| 11 | Initial public offering investor valuations: an examination of top management team prestige and environmental uncertainty 显示文摘 | Lester R H Certo S T Dalton C M Dalton D R Cannella A A | 2006 | Journal of Small Business Management2006，44，1： | 1 |
| 12 | Homocysteine signal cascad: production of phosphslipids, activation of protein kinase C , and the induction of c-los and c-myb in smooth muscle cells显示文摘 | DALTON M L GADSON P F WRENN R W | 1997 | FASEB J1997，11，： | 1 |
| 13 | Frogs Put in the Gender Blender by America's Favourite Herbicides显示文摘 | Dalton R | 2002 | Nature2002，416，6882： | 1 |
| 14 | Effects of antiagglomerants on the interactions between hydrate particles显示文摘 | Mark R A J Dalton Y Luke H | 2007 | American Institute of Chemical Engineers2007，54，2： | 1 |
| 15 | Hepatitis E: an emerging infection in developed countries 显示文摘 | Dalton HR Bendall R Ijaz S | 2008 | Lancet Infect Dis2008，8，： | 1 |
| 16 | Serum creatinine and glomerular filtration rate:perception and reality显示文摘 | Dalton R N | 2010 | Clin Chem2010，56，5： | 1 |
| 17 | Hepatitis E: an emerging infection in developed countries显示文摘 | Dalton HR Bendall R Ijaz S | 2008 | Lancet Infee Dis2008，8，11： | 1 |
| 18 | CEO duality and organizational performance :a longitudinal analysis 显示文摘 | Rechner Panla L: Dalton Dan R | 1991 | Strategic Management Journal1991，1，2： | 1 |
| 19 | Hepatitis E: an emerging infection in developed countries 显示文摘 | Dalton H R Bendall R Ijaz S | 2008 | Lancet Infect Dis2008，8，11： | 1 |
| 20 | Recent advances in non-linear of spectroscopy and nonlinear optical materials显示文摘 | Dalton L R Sapochak L S | 1993 | J Phys Chem1993，97，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员