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您的检索式：作者名="Christopher Bellamy"
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| 1 | Hepatitis E virus in patients with acute severe liver injury显示文摘AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit.METHODS: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain reaction.RESULTS: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient died from sepsis and liver failure precipitated as a result of hepatitis E infection and previously undiagnosed cirrhosis. Histopathology data to date is limited to mainly that seen for endemic HepE. All patients, with the exception of patient 1, demonstrated characteristics of HepE infection, as seen in previously described locally acquired cases.CONCLUSION: In patients with acute severe liver injury, HEV testing should be part of the initial diagnostic investigation algorithm irrespective of suspected initial diagnosis, age or travel history. | Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy Janice Davidson Harry R Dalton Linda Scobie | 2014 | World Journal of Hepatology2014，6，6： | 4 |
| 2 | p53 and poptosis显示文摘 | Christopher O C Bellamy | 1997 | British Medical Bulletin1997，53，： | 1 |
| 3 | Retrospective analysis of the results of liver transplantation for adults with severe hepatopulmonary syndrome显示文摘 | Eric A. Collisson Hamid Nourmand Mark H. Fraiman Christopher B. Cooper Paul E. Bellamy Douglas G. Farmer John M. Vierling Rafik M. Ghobrial Ronald W. Busuttil | 2002 | Liver Transplantation2002，，10： | 1 |
| 4 | LIVER TRANSPLANTATION FOR ALCOHOLIC CIRRHOSIS: LONG TERM FOLLOW-UP AND IMPACT OF DISEASE RECURRENCE1显示文摘 | Christopher O.C. Bellamy Andrea M. DiMartini Kris Ruppert Ashok Jain Forrest Dodson Michael Torbenson Thomas E. Starzl John J. Fung Anthony J. Demetris | 2001 | Transplantation2001，，4： | 1 |
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