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| 1 | Immunosuppression for in vivo research: state-of-the-at protocols and experimental approaches显示文摘几乎,用非自体同源的房间,织物或机关移植的每试验性的治疗策略在临床的翻译前在小、大的动物模型被测试。因为这些策略在大多数情况中要求免疫力的抑制,抑制免疫力的协议是在移植实验的一个关键元素。然而,没有详细知识,标准抑制免疫力的协议经常在特别试验性的背景以内并且在选择模型种类关于他们的功效被使用。如此的协议的优化对到人的病人的试验性的结果的翻译恰当,因此,保证推进调查。这评论与种类特定的药 metabolization 和副作用的考虑关于抑制免疫力的药类以及他们的剂量和应用程序政体总结当前的知识。它也总结新奇 immunomodulatory 策略的当代的知识,例如间充质的干细胞或抗体的使用。因此,这评论被打算用作一个最先进的概要让研究人员精制应用试验性的免疫力的抑制和 immunomodulation 策略提高现出症状之前的潜的移植研究的预兆的价值。 | Rita Diehl Fabienne Ferrara Claudia Müller Antje Y Dreyer Damian D McLeod Stephan Fricke Johannes Boltze | 2017 | Cellular & Molecular Immunology2017，14，2： | 5 |
| 2 | Restless legs syndrome is contributing to fatigue and low quality of life levels in hemodialysis patients显示文摘AIM To examine whether hemodialysis(HD) patients with restless legs syndrome(RLS) are subjects of greater fatigue and impaired quality of life(QoL) compared to HD patients without RLS.METHODS Eighty five stable HD patients participated in this study. According to their RLS status, the patients were dividedinto the RLS group(n = 23) and the non-RLS group(n = 62). QoL, fatigue, sleep quality, daily sleepiness and depression symptoms were assessed by using various questionnaires. Finally, biochemical parameters including iron, ferritin, hemoglobin, hematocrit and parathormone were assessed. RESULTS The HD patients with RLS scored worse in all the questionnaires used in the study(P < 0.05). The patients with RLS were more likely to receive the HD therapy on the morning shift, whilst 43.5% of the RLS patients reported to experience the RLS symptoms also during HD. The severity of RLS was correlated with fatigue, depression score and sleep quality(P < 0.05). CONCLUSION HD patients with RLS are subject to lower QoL related parameters and greater fatigue compared to HD patients without RLS. RLS should be successfully managed in order to improve the QoL of the sufferers. | Christoforos D Giannaki Michael Hadjigavriel Akis Lazarou Aristos Michael Loukas Damianou Efthimios Atmatzidis Ioannis Stefanidis Georgios M Hadjigeorgiou Giorgos K Sakkas Marios Pantzaris | 2017 | World Journal of Nephrology2017，6，5： | 3 |
| 3 | Immuno-haematologic and virologic responses and predictors of virologic failure in HIV-1 infected adults on first-line antiretroviral therapy in Cameroon显示文摘Background:Contemporary data on the immunologic,haematologic and virologic responses and predictors of virologic failure after initiation of free antiretroviral treatment in Cameroon are needed to evaluate the current treatment-monitoring algorithm and to complement efforts to scale-up and improve on the management of HIV infections.Methods:This was a cross-sectional study conducted between October 2010 and June 2012.A total of 951 participants aged 18-74 years were recruited from selected approved HIV treatment centres of the Northwest and Southwest regions.This comprised 247 males and 704 females.Demographic,self-reported risk behaviours and socioeconomic data were obtained using a structured questionnaire.Full blood and CD4+T-cell counts were done using standard automated techniques.Determination of viral load(VL)was done using Abbott RealTime HIV-1 m2000™system.Data was analysed using SPSS version 17.The statistical significance level was P<0.05.Results:The median duration of antiretroviral therapy(ART)was 24 months.The population mean CD4+T-cell count was 255.3 cells/μL[95%CI,236.8-273.9].Overall,45.9%,43.8%and 10.2%of the participants had CD4+T-cell counts of<200 cells/μL,200-499 cells/μL and>500 cells/μL respectively.Anaemia was present in 26.2%of the participants with 62.3%,25.7%and 12%described as mild,moderate and severe anaemia respectively.Virologic failure occurred in 23.2%of the participants with 12.3%having VL>10,000 RNA copies/mL.Meanwhile 76.8%of patients attained adequate viral suppression with 40.8%having undetectable viral load.The age group 18-29 years(p=0.024),co-infection with tuberculosis(p=0.014),anaemia(p=0.028)and distance from the treatment centre(p=0.011)independently predicted virologic failure.Conclusion:The majority of the participants achieved adequate viral suppression after≥6 months of ART.Despite these favourable immuno-haematologic and virologic outcomes,the National AIDS Control Program should step-up efforts to improve on antiretroviral drug distribution,as well as proper assessment and management of anaemia,foster early diagnosis and treatment of tuberculosis and enhance treatment adherence counselling especially in younger patients. | Henry D Meriki Kukwah A Tufon Mbunkah H Afegenwi Bernard A Nyindem Pascal N Atanga Damian N Anong Fidelis Cho-Ngwa Theresa Nkuo-Akenji | 2014 | Infectious Diseases of Poverty2014，3，1： | 3 |
| 4 | Accelerated evolution of resistance in multidrug environments 显示文摘 | HEGRENESS M SHORESH N DAMIAN D | 2008 | PNAS2008，105，13： | 1 |
| 5 | The influence of light and nutrients on buoyancy,filament agreegation and flotation of Anabaena circinalis显示文摘 | JUSTIN D B GEORGE G G DAMIAN G | 1999 | Journal of Plankton Research1999，21，2： | 1 |
| 6 | Effect of an axial magnetic field on the flow pattern in a cylindrical floating zone 显示文摘 | Pablo V D Damian R | 2005 | Advances in Space Research2005，36，1： | 1 |
| 7 | Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina显示文摘 | Damian D Alexander J J O'Rourke JR | 2008 | J Neurosci2008，28，19： | 1 |
| 8 | Psychopathology,adversity,and creativity:Diversifying experiences in the development of eminent African Americans显示文摘 | Damian R I Simonton D K | 2015 | Journal of Personality and Social Psychology2015，108，4： | 1 |
| 9 | Coenzyme Q10 Combined With Mild Hypothermia After Cardiac Arrest : A Preliminary Study 显示文摘 | Damian MS Ellenberg D Gildemeister R | 2004 | Circulation2004，110，19： | 1 |
| 10 | P - glycoprotein, lung resistance - related protein and multidrug resistance - associated protein in de novo adult actue lymphoblastic leukaemia显示文摘 | Damian D Michelutti A | 2002 | Br J Haematol2002，116，3： | 1 |
| 11 | Prevalence of virulence genes in Escherichia coli strains isolated from Romanian adult urinary tract infection cases显示文摘 | Usein CR Damian M Tatu-Chitoiu D etal | 2001 | J Cell Mol Med2001，5，： | 1 |
| 12 | Molecular modeling of thermo-responsive hydrogels: Observation of lower critical solution temperature 显示文摘 | Sanket D Damian A M Thomas M | 2009 | Soft Matter2009，5，： | 1 |
| 13 | Perceptually lossless medical image coding显示文摘 | Wu D Damian M T Marilyn B | 2006 | IEEE Transactions on medical imaging2006，25，3： | 1 |
| 14 | Low - dose UVA and UVB have different time courses for suppression of contact hypersensitivity to a recall antigen in humans 显示文摘 | Damian D Barnetson R Halliday G | 1999 | J Invest Dermatol1999，112，6： | 1 |
| 15 | Demodex infestation in a child with leukaemia:treatment with ivermectin and permethrin显示文摘 | Rogers M | 2003 | Int J Dermatol2003，42，9： | 1 |
| 16 | Evidence for a Na+/H+ antiporter in an alkaliphilic cyanobacterium Synechocystis显示文摘 | Buck Geoffrey D Smith | 1995 | FEMS Microbiology Letters1995，128，： | 1 |
| 17 | Managingand Sharing Servents'Reputations in P2P Systems显示文摘 | Damian E di Vimercati S D C Paraboschi S | 2003 | IEEETransactions on Data and Knowledge Engineering2003，15，4： | 1 |
| 18 | Applications of a new subspace clustering algorithm (COSA)in medical systems biology显示文摘 | Damian D Oresic M | 2007 | Metabolomics2007，3，1： | 1 |
| 19 | Regulation of the gibberellin pathway by auxin and DELLA proteins显示文摘 | Damian P O Sandra E D | 2010 | Planta2010，232，： | 1 |
| 20 | Percutaneous injection of thrombin for the treatment of pseudoaneurysms after catheterization: an alternative to sonographically guided compression显示文摘 | John A P Damian E D John J C | 2000 | American journal of Roentgenology2000，175，24： | 1 |
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