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| 1 | Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRα in human UCP1 expression显示文摘我们调查了胎儿的间充质的干细胞(fMSCs ) 的能力区分进棕色、白的 adipocytes 并且比较了很多标记基因和关键规章的因素的表示。我们证明关键 adipocyte 管理者和标记的表示在另外的人、鼠科的 adipocyte 模型在区别期间类似于那,包括 PPAR 纬 2 和 FABP4 的正式就职。尤其是,我们发现 preadipocyte 标记, Pref-1,当这个过程继续,显著地在区别然后衰落早被导致,当他们承诺 adipogenic 系,建议 fMSCs 首先获得 preadipocyte 特征,在他们进成熟 adipocytes 的区别以前。在 adipogenic 正式就职以后,某干细胞孤立区分了进类似于棕色的 adipocytes 和其它进白 adipocytes 的房间。一个的详细调查孤立证明新奇棕色的胖决定的因素 PRDM16 在区别前后两个都被表示。重要地,展出的这些房间提高了基础 UCP-1 表示,它依赖于孤儿的活动原子受体犯错伪,加亮一个新奇角色为犯错在人的棕色的脂肪的伪。因此 fMSCs 代表一在 vitro 有用为人的 adipogenesis 当模特儿,并且提供机会在对 adipocyte 系的承诺以前学习阶段。他们也提供无价的卓见进人的棕色的脂肪的特征。 | Daniel L Morganstein Pensee Wu Meritxell R Mane Nick M Fisk Roger White Malcolm G Parker | 2010 | Cell Research2010，20，4： | 5 |
| 2 | Transcystic Common Bile Duct Exploration in the Management of Patients With Choledocholithiasis显示文摘 | Sergio Rojas-Ortega Daniel Arizpe-Bravo Eduardo R Mar??n López Rachid Cesin-Sánchez Gerardo Reed-San Roman Crispina Gómez | 2003 | Journal of Gastrointestinal Surgery2003，，4： | 3 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | 多重结局的多元Meta分析和多重治疗的网状Meta分析:原理、概念及实例显示文摘英国国家健康与临床优选研究所(NICE)等组织需要对现有研究获得的证据进行整合来指导决策,需要确定关于多重疗效及安全性结局的最佳治疗。但是,相关的研究不一定对所有关注的治疗或结局都进行了直接比较,多元Meta分析及网状Meta分析为如何确定最佳治疗这一问题提供了思路,该方法不仅考虑了直接证据,还利用了关联或间接的证据。本文中,研究者描述了这些方法学的重要概念及假设,并阐述关联及间接证据如何产生,同时通过图表说明这些证据在涉及多重结局和多重治疗的真实临床案例中如何使用。 | Richard D Riley Dan Jackson Georgia Salanti Danielle L Burke Malcolm Price Jamie Kirkham Ian R White 孙至佳(译) 张岩(译) 刘雪晴(译) 杨智荣(校) 孙凤(校) | 2018 | 英国医学杂志中文版2018，21，12： | 2 |
| 5 | Why the Western Pacific Subtropical High Has Extended Westward since the Late 1970s显示文摘 | Zhou Tianjun Yu Rucong Zhang Jie Drange Helge Cassou Christophe Deser Clara Hodson Daniel L R Sanchez-Gomez Emilia Li Jian Keenlyside Noel Xin Xiaoge Okumura Yuko | 2009 | Journal of Climate2009，，8： | 2 |
| 6 | Prospective comparison of a new chromogenic medium, MRSASelect, to CHROM agar MRSA and mannitol - salt medium supplemented with oxacillin or cefoxitin for detection of methicillin - resistant Staphyiococcus aureus 显示文摘 | Stoakes L Reyes R Daniel J | 2006 | J Clin Microbiol2006，44，2： | 1 |
| 7 | Prospective comparison of a new chromogenic medium,MRSA Selec,to CHROMagar MRSA and mannitol-salt medium supplemented with oxacillin or cefoxitin for detection of methicillin-resistant Staphylococcus aureus显示文摘 | Stoakes L Reyes R Daniel J | 2006 | J Clin Microbiol2006，44，2： | 1 |
| 8 | Depletion patterns of radioactivity and tissue residues in beef cattle after the withdrawal of oral 14C-Diethylstilbestrol 显示文摘 | Rumsey T S Oltjen R R Daniels F L | 1975 | J Anim Sci1975，40，3： | 1 |
| 9 | Guaranteed passive balancing transformations for model order reduction 显示文摘 | Phillips J R Daniel L Silveira L M | 2003 | IEEE Transactions on Computer aided Design of Integrated Circuits and Systems2003，22，8： | 1 |
| 10 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 11 | Are there better indices for evalu- ation purposes than the h index? A comparison of nine different variants of the h index using data from biomedicine 显示文摘 | Bornmann L Mutz R Daniel H D | 2008 | Journal of the Ameri- can Society for Information Science and Technology2008，59，5： | 1 |
| 12 | Lin- ear trichromium complexes with direct Cr to Cr contacts: 2 : Compounds with Cr3 (dipyridylamide) 4^3+cores 显示文摘 | CLERAC R COTTON F A DANIELS L M | 2000 | Inorg Chem2000，39，： | 1 |
| 13 | A multi-objective approach to resource alloca tion in single machine scheduling显示文摘 | Daniels R L | 1990 | European Journal of Operational Research1990，48，： | 1 |
| 14 | Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phospholnosltol 4, 5 bisphosphate 显示文摘 | Daniels R L Takashima Y McKemy D D | 2009 | J Biol Chem2009，284，： | 1 |
| 15 | Reliability challengesin large systems 显示文摘 | Daniel A R Charng-da L? Celso L M | 2006 | Future Generation Computer Systems2006，22，3： | 1 |
| 16 | Are there better indices for evaluation purposes than the h-index? A comparison of nine different variants of the h index using data from biomedicine显示文摘 | Bornmann L Mutz R Daniel HD | | 0，，05： | 1 |
| 17 | Vibrio parahaemolyticusinfections in the United States,1973-1998显示文摘 | Daniels NA MacKinnon L Bishop R | 2000 | J Infect Dis2000，181，5： | 1 |
| 18 | Are there better in- dices for evaluation purposes than the h index? a comparison of nine different variants of the h index using data from biomedi- cine 显示文摘 | BORNMANN L MUTZ R DANIEL H D | 2008 | Journal of the American Society for Information Sci- ence and Technology2008，59，5： | 1 |
| 19 | Multiply scattered aerosol lidar returns: inversion method and coMParison with in situ measurements 显示文摘 | Luc R Bissonnettle Daniel L Hutt | 1995 | APPLIED OPTICS1995，34，30： | 1 |
| 20 | Vibrio para-haemolyticus infections in the United States,1973-1998 显示文摘 | Daniels NA MacKinnon L Bishop R | 2000 | J Infect Dis2000，181，5： | 1 |
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