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| 1 | Metastatic type 1 gastric carcinoid:A real threat or just a myth?显示文摘AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were recorded.Patients’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and histopathologically.Patients were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded.The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years.The mean follow-up period was 83 mo.Twelve patients had regional lymph node metastases and 8 patients had liver metastases.The primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the tumor.The disease was stable in all but 3 patients who had progressive liver disease.All patients remained alive during the follow-up period.CONCLUSION:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels. | Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 2 | Gastric neuroendocrine neoplasms type 1: A systematic review and meta-analysis显示文摘BACKGROUND To date, the histopathological parameters predicting the risk of lymph node (LN) metastases and local recurrence, associated mortality and appropriateness of endoscopic or surgical resection in patients with gastric neuroendocrine neoplasms type 1 (GNENs1) have not been fully elucidated. AIM To determine the rate of LN metastases and its impact in survival in patients with GNEN1 in relation to certain clinico-pathological parameters. METHODS The PubMed, EMBASE, Cochrane Library, Web of Science and Scopus databases were searched through January 2019. The quality of the included studies and risk of bias were assessed using the Newcastle-Ottawa Scale (NOS) in accordance with the Cochrane guidelines. A random effects model and pooled odds ratios (OR) with 95%CI were applied for the quantitative meta-analysis. RESULTS We screened 2933 articles. Thirteen studies with 769 unique patients with GNEN1 were included. Overall, the rate of metastasis to locoregional LNs was 3.3%(25/769). The rate of LN metastases with a cut-off size of 10 mm was 15.3% for lesions > 10 mm (vs 0.8% for lesions < 10 mm) with a random-effects OR of 10.5 (95%CI: 1.4 -80.8;heterogeneity: P = 0.126;I2 = 47.5%). Invasion of the muscularis propria was identified as a predictor for LN metastases (OR: 17.2;95%CI: 1.8-161.1;heterogeneity: P = 0.165;I2 = 44.5%), whereas grade was not clearly associated with LN metastases (OR: 2;95%CI: 0.3-11.6;heterogeneity: P = 0.304;I2 = 17.4%). With regard to GNEN1 local recurrence, scarce data were available. The 5-year disease-specific survival for patients with and without LN metastases was 100% in most available studies irrespective of the type of intervention. Surgical resection was linked to a lower risk of recurrence (OR: 0.3;95%CI: 0.1-1.1;heterogeneity: P = 0.173;I2 = 31.9%). The reported complication rates of endoscopic and surgical intervention were 0.6 and 3.8%, respectively. CONCLUSION This meta-analysis confirms that tumor size ≥ 10 mm and invasion of the muscularis propria are linked to a higher risk of LN metastases in patients with GNEN1. Overall, the metastatic propensity of GNEN1 is low with favorable 5- year disease-specific survival rates reported;hence, no clear evidence of the prognostic value of LN positivity is available. Additionally, there is a lack of evidence supporting the prediction of local recurrence in GNEN1, even if surgery was more often a definitive treatment. | Apostolos V Tsolakis Athanasia Ragkousi Miroslav Vujasinovic Gregory Kaltsas Kosmas Daskalakis | 2019 | World Journal of Gastroenterology2019，25，35： | 6 |
| 3 | Computed tomography-based diagnostics might be insufficient in the determination of pancreatic cancer unresectability显示文摘AIM: To inquire into a question of an overestimation of arterial involvement in patients with pancreatic cancer (PC). METHODS: Radiology data were compared with the findings from 51 standard, 58 extended and 17 total pancreaticoduodenectomies; 9 distal resections with celiac artery (CA) excision; and 28 palliations for PC. The survival of 11 patients with controversial computed tomography (CT) and endoscopic ultrasound data with regard to arterial invasion, after R0/R1 procedures (false-positive CT results, Group A), was compared to survival after eight R2 resections (false-negative CT results, Group B) and after 12 bypass procedures for locally advanced cancer (true-positive CT results, Group C).RESULTS: In all of the cases in group A, operative exploration revealed no arterial invasion, which was predicted by CT. The one-year survival in Group A was 88.9%, and the two-year survival was 26.7%, with a median follow-up of 22 mo. One-year survival was not attained in groups B and C, with a significant difference in survival (P a-b = 0.0029, P b-c = 0.003).CONCLUSION: Arterial encasement on CT does not necessarily indicate arterial invasion. Whenever PC is considered unresectable, endoUS should be used. In patients with controversial CT an EUS data for peripan-creatic arteries involvement radical resection might be possible, providing survival benefits as compared to R2-resections or palliative surgery. | Vyacheslav I Egorov Roman V Petrov Elena N Solodinina Gregory G Karmazanovsky Natalia S Starostina Natalia A Kuruschkina | 2013 | World Journal of Gastrointestinal Surgery2013，5，4： | 4 |
| 4 | Aneuploidy Detection in Mixed DNA Samples by Methylation-Sensitive Amplification and Microarray Analysis 显示文摘 | Lucia B Gregory B Pmn V | 2010 | Clin chem2010，56，5： | 1 |
| 5 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 6 | Genetic and phenotypic (co)variances for growth and carcass traits of purebred and composite populations of beef cattle 显示文摘 | GREGORY K E CUNDIFF L V KOCH R M | 1995 | Journal of Animal Science1995，73，： | 1 |
| 7 | On Completion of Fuzzy Metric Spaces 显示文摘 | Gregori V Romaguera S | 2002 | Fuzzy Sets and Systems2002，130，： | 1 |
| 8 | Epidemiologic evaluation of reoperation for surgically treated pelvic organ prolapse and urinary incontinence显示文摘 | Clark AL Gregory T Smith V J | 2003 | Am J Obstet Gynecol2003，189，5： | 1 |
| 9 | Changes in gene expression by trabecular meshwork cells in response to mechanical stretching显示文摘 | Vittal V Rose A Gregory K E Kelley M J Acott T S | 2005 | Invest Ophthalmol Vis Sci2005，46，： | 1 |
| 10 | MR imaging evaluation of endometrial carcinoma:results of an NCI cooperative study显示文摘 | Hedvig H Lawrence V R Gregory M G | 1991 | Radiology1991，179，6： | 1 |
| 11 | Elective segmental ureter- ectomy for transitional cell carcinoma of the ureter: long - term fol-low-up in a series of 73 patients显示文摘 | Simonato A Varca V Gregori A | 2012 | BJU Int2012，110，11： | 1 |
| 12 | Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates 显示文摘 | Lin YP Shaw M Gregory V | 2000 | Proc Natl Acad Sci U S A2000，97，17： | 1 |
| 13 | A reduced-order model for electrically actuated clamped circular plates 显示文摘 | Gregory W V Nayfeh A H | 2005 | Journal of Micromechanics and Microengineering2005，15，4： | 1 |
| 14 | Review : The enigmatic role of endoglin in the placenta 显示文摘 | Gregory AL Xu G Sotov V | 2014 | Placenta2014，35，： | 1 |
| 15 | Review: the enigmatic role of endoglin in the placenta显示文摘 | Gregory AL Xu G Sotov V | 2014 | Placenta2014，，： | 1 |
| 16 | Prevalence of hearing impairment in a rural health study, 1994 to 1998 显示文摘 | Gregory A Flamme V Mudipalli R | 2005 | Ear Hearing2005，26，3： | 1 |
| 17 | Avian-to-human transmission of H9N2 subtype influenza A viruses: Re- lationship between H9N2 and H5N1 human isolates 显示文摘 | Lin Y P Shaw M Gregory V | 2000 | PNAS2000，97，17： | 1 |
| 18 | An ecosystem perspective of riparian zone显示文摘 | GREGORY S V SWARTSON F J McKee W A | 1991 | Bioscience1991，41，： | 1 |
| 19 | Avian-to-human transmission of HgN2 subtype influenza A viruses: Relationship between H9N2 and H5N1 hmnan isolates 显示文摘 | Lin Y P Shaw M Gregory V | 2000 | PNAS2000，97，17： | 1 |
| 20 | An ecosystem perspective on riparian zones 显示文摘 | Gregory S V Swanson F J McKee W A | 1991 | Bioscience1991，41，8： | 1 |
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