2篇
您的检索式：作者名="DAOMING LIANG"
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| 1 | Epithelial-mesenchymal transition contributes to malignant phenotypes of circulating tumor cells derived from gastric cancer显示文摘Circulating tumor cells(CTCs)are crucial to tumor metastasis,and they usually undergo epithelial-mesenchymal transition(EMT)in order to disseminate from the primary tumor.However,very little is currently known about the relationship between EMT and malignant phenotypes of CTCs in the context of gastric cancer.Therefore,this study aimed to investigate the contribution of EMT to malignant phenotypes of CTCs derived from gastric cancer cells.We xenografted MKN28 gastric cancer cells pretreated with transforming growth factor-beta 1(TGFβ-1)into nude mice by intravenous injection.Next,we isolated CTCs from the blood of nude mice by gradient centrifugation and found that CTCs derived from MKN28 cells pretreated with TGFβ-1 had a significantly increased viability and invasion ability compared to MKN28 cells without TGFβ-1 treatment.Immunocytochemical staining showed lower expression of E-cadherin and higher expression of N-cadherin,vimentin,and β-catenin in CTCs derived from MKN28 cells pretreated with TGFβ-1.Furthermore,the expression of Wnt3a,β-catenin,cyclin D1,and c-Myc was significantly higher in CTCs derived from MKN28 cells pretreated with TGFβ-1.Taken together,these findings suggest that TGFβ promotes EMT and malignant phenotypes of gastric cancer cells.Furthermore,the malignant phenotypes of gastric cancer cells induced by TGFβ are maintained in CTCs derived from these cells.Targeting EMT in CTCs is a new approach to the treatment of gastric cancer relapse and metastasis. | TIANGEN WU TIANHAO BAO DAOMING LIANG LIN WANG | 2019 | BIOCELL2019，43，4： | 0 |
| 2 | EFFECT OF TEST TEMPERATURE ON DEFORMATION MECHANISM OF Ti_3Al-Nb ALLOY显示文摘EFFECTOFTESTTEMPERATUREONDEFORMATIONMECHANISMOFTi3AlNbALLOY①WuYing,LiangWei,CuiYuexian,LiDaoming,YangDezhuangSchoolofMateria... | Wu Ying, Liang Wei, Cui Yuexian, Li Daoming, Yang Dezhuang School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001 | 1997 | 中国有色金属学会会刊:英文版1997，7，2： | 0 |
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