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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | 冠状动脉钙化用于指导个性化阿司匹林治疗以预防心血管病:基于多民族动脉粥样硬化研究显示文摘最近美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)的一级预防指南建议,低剂量阿司匹林治疗仅适用于年龄40~70岁、患动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease,ASCVD)风险较高,但出血风险不高的成年人。然而,尚不清楚如何更准确地识别出这些患者。根据2019年降低心血管病相对危险度和出血风险的阿司匹林荟萃分析研究数据,本研究旨在评估冠状动脉钙化(coronary artery calcium,CAC)在指导阿司匹林在一级预防中如何使用的价值。 | 周卫(译) 叶鹏(摘/审校) Achirica MC Miedema MD McEvoy JW Rifai MA Greenland P Dardari Z Budoff M Blumenthal RS Yeboah J Duprez DA Mortensen MB Dzaye O Hong J Nasir K Blaha MJ | 2020 | 中华高血压杂志2020，28，4： | 2 |
| 3 | Aging activates adipogenic and suppresses osteogenic programs in mesen-chymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways 显示文摘 | Moerman E J Teng K Lipschitz DA | 2004 | Aging Cell2004，3，6： | 1 |
| 4 | Venompresent in sea anemone (Heteractis magnifica)induces apoptosis innon-small-cell lung cancer A549 cells through activation of mito-chondria-mediated pathway显示文摘 | RAMEZANPOUR M DA SILVA K B SANDERSON B J | 2014 | Biotechnol Lett2014，36，3： | 1 |
| 5 | Study of the preparation and catalytic performance of molybdenum carbide catalysts prepared with C2H2/H2 carburizing mixture显示文摘 | XIAO T C WANG H T DA J W COLEMAN K S GREEN M L | 2002 | J Catal2002，211，1： | 1 |
| 6 | Pennicillin in duced epileptiform activity in the hippocampal in vitro preparation显示文摘 | Prince DA Crews J K | 1981 | Ann Neurol1981，1，： | 1 |
| 7 | Com- putational fluid dynamics framework for aerodynamic model assessment显示文摘 | VALLESPIN D BADCOCK K J RONCH A DA | 2012 | Progress in Aerospace Sciences2012，52，： | 1 |
| 8 | Investigations on gossypol: past and present developments 显示文摘 | Dodou K Anderson R J Small DA | 2005 | Expert Opin In- vestig Drugs2005，14，11： | 1 |
| 9 | Polymorphlsm of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD)显示文摘 | SONG J DA COSTA K A FISCHER L M | 2005 | FASEB J2005，19，： | 1 |
| 10 | Discrimination of dementia with Lewy bodies from Alzheimer disease and Parkinson disease using the clock drawing test显示文摘 | Cahn-Weiner DA Williams K Grace J | 2003 | Cogn Behav Neurol2003，16，： | 1 |
| 11 | Streptokinase antihcties in patients presenting with acute coronmy syndrome in three ru- ral New Zealand populations 显示文摘 | Nixon G Blatlner K Da son J | 2011 | Journal of clinical pathology2011，64，5： | 1 |
| 12 | Genome-wide haplotype association study identifies the SLC22A3-LPAL2- LPA gene cluster as a risk locus for coronary artery disease 显示文摘 | Tr6gou~t DA K~nig IR Erdmann J | 2009 | Nat Genet2009，41，3： | 1 |
| 13 | Synergistic reversal of intrahepatic HCV- specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade 显示文摘 | Nakamoto N Cho H Shaked A Olthoff K Valiga ME Kaminski M Gostick E Price DA Freeman GJ Wherry E J Chang KM | 2009 | PLoS Pathog2009，5，10： | 1 |
| 14 | Prognostic significance of immunophenotypic and karyotypic features of Philadelphia positive B-lymphoblastic leukemia in the era of tyrosine kinase inhibitors 显示文摘 | Jaso J Thomas DA Cunningham K | 2011 | Cancer2011，117，17： | 1 |
| 15 | Adsorption and transport of gases in a supported microporous sili- ca membrane显示文摘 | Gao X Diniz da Costa J C Bhatia S K | 2014 | J Membr Sci2014，460，： | 1 |
| 16 | Genome-wide comparative diversity uncovers multiple targets of selection for improvement in hexaploid wheat landraces and cultivars 显示文摘 | Cavanagh CS Chao S Wang BE Huang BE Stephen S Kiani S Forrest K Saintenac C Brown-Guedira GL Akhunova A See D Bai G Pumphrey M Tomar L Wong D Kong S Reynolds M da Silva ML Bockelman H Talbert L Anderson JA Dreisigacker S Baenziger S Carter A Korzun V Morrell PL Dubcovsky J Morell MK Sorrells ME Hayden MJ Akhunov E | 2013 | PNAS2013，110，： | 1 |
| 17 | Correlation of CT findings with clinical evalua- tions in 261 patients with symptomatic bronehieetasis显示文摘 | Lynch DA Newell J Hale V Dver D Corkerv K Fox NL Ger-end P Fick R | 1999 | AJR Am J Roentyenol1999，173，1： | 1 |
| 18 | Identification of potential cell-surfaceproteins in Candida albicans and investigation of the role of aputative cell-surface glycosidase in adhesion and virulence显示文摘 | Alberti-Segui C Morales A J Xing H Kessler M M Willins DA Weinstock K G | 2004 | Yeast2004，21，： | 1 |
| 19 | MR imaging of the female urethra and supporting ligaments in assessment of urinary inconti- nence : spectrum of abnormalities 显示文摘 | Macura K J Genadry RR Bluemke DA | 2006 | RadioGraphics2006，26，4： | 1 |
| 20 | Characterization of a two - aqueous phase system con- taining a nonionic surfactant 显示文摘 | TEIXEIRA DA SILVA DE LA SALLES K CANSELIER J P GOURDON C | 2005 | Journal of Dispersion Science and Technolagy2005，26，3： | 1 |
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