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| 1 | Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis显示文摘Hyperuricemia-mediated uric acid crystal formation may cause joint inflammation and provoke the destruction of joints through the activation of inflammasome-mediated innate immune responses.However,the immunopathological effects and underlying intracellular regulatory mechanisms of uric acid crystal-mediated activation of fibroblast-like synoviocytes(FLS)in rheumatoid arthritis(RA)have not been elucidated.Therefore,we investigated the in vitro effects of monosodium urate crystals,alone or in combination with the inflammatory cytokines tumor-necrosis factor(TNF)-a or interleukin(IL)-1b,on the activation of human FLS from RA patients and normal control subjects and the underlying intracellular signaling mechanisms of treatment with these crystals.Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6,the chemokine CXCL8 and the matrix metalloproteinase(MMP)-1 from both normal and RA-FLS(all P,0.05).Moreover,the additive or synergistic effect on the release of IL-6,CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-a or IL-1b.Further experiments showed that the release of the measured inflammatory cytokine,chemokine and MMP-1 stimulated by monosodium urate crystals were differentially regulated by the intracellular activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways but not the p38 mitogen-activated protein kinase pathway.Our results therefore provide a new insight into the uric acid crystal-activated immunopathological mechanisms mediated by distinct intracellular signal transduction pathways leading to joint inflammation in RA. | Da P Chen Chun K Wong Lai S Tam Edmund K Li Christopher WK Lam | 2011 | Cellular & Molecular Immunology2011，8，6： | 5 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 4 | 顽固性高血压与由心内容积决定的血管内液体潴留无关显示文摘顽固性高血压(refractory hypertension,RfHTN)是一种极端的抗高血压治疗失败的表现形式,定义为使用了包括长效噻嗪类和盐皮质激素受体拮抗剂在内的≥5种药时血压仍控制欠佳。RfHTN是难治性高血压(resistant hypertension,RHTN)的一个亚组,RHTN定义为使用≥3种降压药(包括利尿剂)后血压仍〉135/85mm Hg(1mm Hg=0.133kPa)。 | 刘青 叶鹏 Velasco A Siddiqui M Kreps E Kolakalapudi P Dudenbostel T Arora G Judd EK Prabhu SD Lloyd SG Oparil S Calhoun DA | 2018 | 中华高血压杂志2018，26，7： | 2 |
| 5 | Parametric Study of Adhesive Joints with Composites 显示文摘 | NETO J A B P CAMPILHO R D S G DA SILVA L F M | 2012 | International Journal of Adhesion and Adhesives2012，，： | 1 |
| 6 | Experimental assessment of perfobond and T- perfobond shear connectors' structural response 显示文摘 | Vianna J da C Costa-Neves L F da S Vellasco P C G | 2008 | Journal of Constructional Steel Research2008，65，2： | 1 |
| 7 | Inhibition of metal- loproteinases derived from tumours: new insights in the treat- ment of human glioblastoma显示文摘 | Gabelloni P Da Pozzo E Bendinelli S | 2010 | Neuroscience2010，168，2： | 1 |
| 8 | Correlation between melphalan pharmacokinetics and hepatic toxicity following hyperthermic isolated liver perfusion for unresectable metastatic disease显示文摘 | Mocellin S Pilati P Da Pian P | 2007 | Ann Surg Oncol2007，14，： | 1 |
| 9 | Immune system and immune responses in fish and their role in com- parative immunity study: a model for higher organisms 显示文摘 | RAUTA P R NAYAK B DA S S | 2012 | Immunology Letters2012，148，1： | 1 |
| 10 | Molecular differenc- es between hydrocarbon and fluorocarbon surfaetants at the COJ water interface 显示文摘 | Stone M T Da Rocha S R P Rossky P J | 2003 | Journal of Physics Chemistry2003，107，10： | 1 |
| 11 | A parametric study of forced convection in an enclosure with stationary heated cylinders显示文摘 | Guimar?es P M Da Silva C E S | 2010 | International Communications in Heat and Mass Transfer2010，37，5： | 1 |
| 12 | Structural behaviour of T-perfobond shear connectors in composite girders: An experimental approach显示文摘 | Vianna J da C Costa-Neves L F da S Vellasco P C G | 2008 | Engineering Structures2008，30，9： | 1 |
| 13 | Comparison of a new gold-immunochromato graphic assay for the detection of antibodies against avian influenza virus with hemagglutination inhibition and agar gel immuno diffusion assays显示文摘 | Da P P Si S H Yan H | 2007 | Veterinary Immunology and Immunopathology2007，117，12： | 1 |
| 14 | Development and characterization of phosphatidylcholine nanovesicles containing the antimicrobial peptide nisin 显示文摘 | DA SILVA MALHEIROS P MICHELETTO Y M S DA SILVEIRA N P | 2010 | Food Res Inter2010，43，4： | 1 |
| 15 | Radiographics Pattern Recognition of Welding Defects Using Linear Classifiers显示文摘 | R R da Silva M H S Siqueira L P Caloba etc | 2001 | Insight2001，，10： | 1 |
| 16 | Detailed aH and 13C NMR structural assignment of three biologically active lignan lactones 显示文摘 | Vladimir C G H Rosangela da S Susimaire P | 2006 | Spectroehim Aeta PartA2006，63，： | 1 |
| 17 | A comparison between theAPACHE II and Charlson Index Score for predicting'hospital mortalityin critically ill patients 显示文摘 | Quach S Hennessy DA Fans P | 2009 | BMC Health Services Research2009，9，1： | 1 |
| 18 | Total, insoluble and soluble dietary fiber values measured by enzymatic-gravimetric method in cereal grains 显示文摘 | Da SILVA L P CIOCCAM de L S | 2005 | Journal of Food Composition and Anlysis2005，18，1： | 1 |
| 19 | Classification of edible oils and modeling of their physico-chemical properties by chemometric methods using mid-IR spectroscopy显示文摘 | Luna A S da Silva A P Ferre J | 2013 | Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy2013，100，： | 1 |
| 20 | Water in car- bon dioxide macroemulsions and miniemulsions with a hydrocar- bon surfactant显示文摘 | Johnston K P Cho Dongman Da Rocha S R P | 2001 | Langmuir2001，17，23： | 1 |
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