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| 1 | Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis显示文摘Hyperuricemia-mediated uric acid crystal formation may cause joint inflammation and provoke the destruction of joints through the activation of inflammasome-mediated innate immune responses.However,the immunopathological effects and underlying intracellular regulatory mechanisms of uric acid crystal-mediated activation of fibroblast-like synoviocytes(FLS)in rheumatoid arthritis(RA)have not been elucidated.Therefore,we investigated the in vitro effects of monosodium urate crystals,alone or in combination with the inflammatory cytokines tumor-necrosis factor(TNF)-a or interleukin(IL)-1b,on the activation of human FLS from RA patients and normal control subjects and the underlying intracellular signaling mechanisms of treatment with these crystals.Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6,the chemokine CXCL8 and the matrix metalloproteinase(MMP)-1 from both normal and RA-FLS(all P,0.05).Moreover,the additive or synergistic effect on the release of IL-6,CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-a or IL-1b.Further experiments showed that the release of the measured inflammatory cytokine,chemokine and MMP-1 stimulated by monosodium urate crystals were differentially regulated by the intracellular activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways but not the p38 mitogen-activated protein kinase pathway.Our results therefore provide a new insight into the uric acid crystal-activated immunopathological mechanisms mediated by distinct intracellular signal transduction pathways leading to joint inflammation in RA. | Da P Chen Chun K Wong Lai S Tam Edmund K Li Christopher WK Lam | 2011 | Cellular & Molecular Immunology2011，8，6： | 5 |
| 2 | Comparison of multi-lineage cells from human adipose tissue and bone marrow显示文摘 | De Ugarte DA Morizono K Elbarbary A Alfonso Z Zuk PA Zhu M Dragoo JL Ashjian P Thomas B Benhaim P Chen I Fraser J Hedrick MH | | 0，，： | 1 |
| 3 | REffectst of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis显示文摘 | Chun K Wong Da P Chen Lai S Tam | 2010 | Arthritis Research&Therapy2010，12，： | 1 |
| 4 | Optimization of prostate biopsy strategy using computer based analysis显示文摘 | Chen ME Troncoso P Johnston DA | 1997 | J Urol1997，158，6： | 1 |
| 5 | A High quality draft consensus sequence of the genome of a heterozygous grapevine variety显示文摘 | VELASCO R ZHARKIKH A TROGGIO M CARTWRIGHT DA CESTARO A PRUSS D PINDO M FITZGERALD LM VEZZULLI S REID J MALACARNE G ILIEV D COPPOLA G WARDELL B MICHELETTI D MACALMA T FACCI M MITCHELL JT PERAZZOLLI M ELDREDGE G GATTO P OYZERSKI R MORETTO M GUTIN N STEFANINI M CHEN Y SEGALA C DAVENPORT C DEMATYTE L MRAZ A BAT- TILANA J STORMO K COSTA F TAO Q SI-AMMOUR A HARKINS T LACKEY A PERBOST C TAILLON B STELLA A SOLOVYEV V FAWCETY JA STERCK L VANDEPOELE K GRANDO SM TOPPO S MOSER C LANCHBURY J BOGDEN R SKOLNICK M SGARAMELLA V BHATNAGAR SK FONTANA P GUTIN A VAN DE PEER Y SALAMINI F VIOLA R | 2007 | PLoS One2007，2，： | 1 |
| 6 | Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis显示文摘 | Wong CK Chen da P Tam LS | 2010 | Arthritis Res Ther2010，12，4： | 1 |
| 7 | Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea显示文摘 | Amselem J Cuomo C A van Kan J A Viaud M Benito E P Couloux A Coutinho P M de Vries R P Dyer PS Fillinger S Fournier E Gout L Hahn M Kohn L Lapalu N Plummer K M Pradier J M Quévillon E Sharon A Simon A ten Have A Tudzynski B Tudzynski P Wincker P Andrew M Anthouard V Beever R E Beffa R Benoit I Bouzid O Brault B Chen Z Choquer M Collémare J Cotton P Danchin E G Da Silva C Gautier A Giraud C Giraud T Gonzalez C Grossetete S Güldener U Henrissat B Howlett B J Kodira C Kretschmer M Lappartient A Leroch M Levis C Mauceli E Neuvéglise C Oeser B Pearson M Poulain J Poussereau N Quesneville H Rascle C Schumacher J Ségurens B Sexton A Silva E Sirven C Soanes D M Talbot N J Templeton M Yandava C Yarden O Zeng Q Rollins J A Lebrun M H Dickman M | 2011 | PLoS Genetics2011，7，10： | 1 |
| 8 | Effects of inflammatory cyto- kine IL-27 on the activation of fibroblast-like synoviocytes in rheu- matoid arthritis显示文摘 | Wang CK Chen da P Tam LS | 2010 | Arthritis Res Ther2010，12，4： | 1 |
| 9 | Re-peatability of manual subfoveal choroidal thickness measure-ments in healthy subjects using the technique of enhanced depthimaging optical coherence tomography显示文摘 | Rahman W Chen FK Yeoh J Patel P Tufail A Da Cruz L | | Invest OphthalmolVis Sci0，52，5： | 1 |
| 10 | A distinct lineage of influenza A virus from bats 显示文摘 | Tong S Li Y Rivailler P Conrardy C Castillo DA Chen LM Recuenco S Ellison JA Davis CT York IA Turmelle AS Moran D Rogers S Shi M Tao Y Weil MR Tang K Rowe LA Sammons S Xu X France M Lindblade KA Cox NJ Anderson LJ Rupprecht CE Donis RO | 2012 | Proc Natl Acad Sci USA2012，109，11： | 1 |
| 11 | The learning curve for acoustic tumor surgery 显示文摘 | Buchman CA Chen DA Flannagan P | 1996 | Laryngoscope1996，106，11： | 1 |
| 12 | Effects of inflammatory eytokine 11,-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis显示文摘 | Wong CK Chen da P Tam LS | 2010 | Arthritis Res Ther2010，12，： | 1 |
| 13 | Effects of in- flammatory cytokine IL-27 on the activation of fibroblast -like synoviocytes in rheumatoid arthritis 显示文摘 | Chun K Wong Da P Chen Lai S Tam | 2010 | Arthritis Research & Therapy2010，12，4： | 1 |
| 14 | Effects of inflammatory cytokine iL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis显示文摘 | Wong C K Chen da P Tam L S | 2010 | Arthritis Res Ther2010，12，4： | 1 |
| 15 | Genetic Characterization of Highly Pathogenic Avian Influenza A(H5N6)Virus,Guangdong,China显示文摘 | Mok C K Da Guan W Liu X Q Lamers M M Li X B Wang M Zhang T J Zhang Q L Li Z T Huang J C Lin J Y Zhang Y H Zhao P Lee H H Chen L Li Y M Peiris J S Chen R C Zhong N S Yang Z F | 2015 | Emerg Infect Dis2015，21，12： | 1 |
| 16 | Comparison of multi-lineage cells from human adipose tissue and bone marrow显示文摘 | De Ugarte DA Morizono K Elbarbary A Alfonso Z Zuk PA Zhu M Dragoo JL Ashjian P Thomas B Benhaim P Chen I Fraser J Hedrick MH | | 0，，： | 1 |
| 17 | Topographic variation and interocular symmetry of macular choroidal thickness using enhanced depth imaging optical coherence tomography 显示文摘 | Chen FK Yeoh J Rahman W Patel P J Tufail A Da Cruz L | 2012 | Invest Ophthalmol Vis Sci2012，53，2： | 1 |
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