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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | 顽固性高血压与由心内容积决定的血管内液体潴留无关显示文摘顽固性高血压(refractory hypertension,RfHTN)是一种极端的抗高血压治疗失败的表现形式,定义为使用了包括长效噻嗪类和盐皮质激素受体拮抗剂在内的≥5种药时血压仍控制欠佳。RfHTN是难治性高血压(resistant hypertension,RHTN)的一个亚组,RHTN定义为使用≥3种降压药(包括利尿剂)后血压仍〉135/85mm Hg(1mm Hg=0.133kPa)。 | 刘青 叶鹏 Velasco A Siddiqui M Kreps E Kolakalapudi P Dudenbostel T Arora G Judd EK Prabhu SD Lloyd SG Oparil S Calhoun DA | 2018 | 中华高血压杂志2018，26，7： | 2 |
| 3 | Tumor necrosis factor alpha prevents tumor necrosis factor receptormediated mouse hepatocyte apoptosis, but not fasmediated apoptosis: role of nuclear factor-kappaB 显示文摘 | Nagaki M Naiki T Brenner DA | 2000 | Hepatology2000，32，6： | 2 |
| 4 | The essential oil of Eucalyptus tereticornis and its constituents, α-and β-pinene, show accelerative properties on rat gastrointestinal transit 显示文摘 | Juca D M Da Silva M T Junior RC Jr | 2011 | Planta Med2011，77，1： | 1 |
| 5 | Chemical composition and free radical scavenging activity of pollen loadsfrom stingless bee Melipona subnitida D\icke显示文摘 | Silva T M S Camara C A da Silva Lins A C | 2006 | Journal of Food Composition and Analysis2006，19，6： | 1 |
| 6 | Profile of microbial communities present in tibico(sugary kefir)grains from different Brazilian States显示文摘 | da CP MIGUEL M G CARDOSO P G MAGALHES K T | 2011 | World Journal of Microbiology and Biotechnology2011，27，8： | 1 |
| 7 | Thermal effect on upconversion fluorescence emission in Er^3+-doped chalcogenide glasses under anti-stokes, stokes and resonant excitation显示文摘 | SILVA C J da ARUJO M T de | 2003 | Opt Mater2003，22，3： | 1 |
| 8 | Nitrogen incorporation into titanium diboride films deposited by dc magnetron sputtering: Structural modifications 显示文摘 | SANCHEZ C M T FONSECA-FILHO H D MAIA DA COSTA M E H | 2009 | Thin Solid Films2009，517，19： | 1 |
| 9 | Least limiting water range:A potential indicator of changes in near-surface soil physical quality afterthe conversion of Brazilian Savanna into pasture显示文摘 | LEO T P DA SILVA AP MACEDO M C M | 2006 | Soil&Tillage Re-search2006，88，： | 1 |
| 10 | Molecular differenc- es between hydrocarbon and fluorocarbon surfaetants at the COJ water interface 显示文摘 | Stone M T Da Rocha S R P Rossky P J | 2003 | Journal of Physics Chemistry2003，107，10： | 1 |
| 11 | Bonded Repair of Composite Aircraft Structures:A Review of Scientific Challenges And Opportunities显示文摘 | Katnam K B Da Silva L Young T M | 2013 | Progress in Aerospace Sciences2013，，61： | 1 |
| 12 | Study of the preparation and catalytic performance of molybdenum carbide catalysts prepared with C2H2/H2 carburizing mixture显示文摘 | XIAO T C WANG H T DA J W COLEMAN K S GREEN M L | 2002 | J Catal2002，211，1： | 1 |
| 13 | Materials Science and Engineering A显示文摘 | Silva M G da Ramesh K T | 1997 | 232:111997，232，： | 1 |
| 14 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 15 | Characterization of polymeric insulators using thermal and UV imaging under laboratory conditions显示文摘 | Da Costa E G Ferreira T V Neri M G G | 2009 | IEEE Transactions on Dielectrics and Electrical Insulation2009，16，4： | 1 |
| 16 | Acomparative study of the viscoelastic constitutivemodels for frictionless contact interfaces insolids 显示文摘 | Alves J Peixinho N Da Silva M T? ei al | 2015 | Mechanism and Machine Theory2015，85，： | 1 |
| 17 | Gastrointestinal stromal tumor:spiral computed tomography features and pathologic correlation显示文摘 | DA RONCH T MODESTO A BAZZOCCHI M | 2006 | Radiol Med2006，111，5： | 1 |
| 18 | Surface ex- pression patterns of negative regulatory molecules identify determinants of virus-specific CD8 T-cell exhaustion in HIV infection 显示文摘 | Yamamoto T Price DA Casazza JP Ferrari G Nason M Chattopadhyay PK Roederer M Gostick E Katsikis PD Douek DC Haubrich R Petrovas C Koup RA | 2011 | Blood2011，117，18： | 1 |
| 19 | Contrast enhanced ultrasound and Dual Source CT of left atrial myxoma显示文摘 | Clevert DA Schweyer M Johnson T | 2007 | Ultraschall Med2007，28，6： | 1 |
| 20 | Post-harvest physiology of cut carnation flowers显示文摘 | Ebrahimzadeh A Jiménez S Teixeira da Silva J A Satoh S Lao M T | | 0，，： | 1 |
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