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| 1 | Short and long term outcomes of 200 patients supported by continuous-flow left ventricular assist devices显示文摘AIM: To study the institutional experience over 8 years with 200 continuous-flow(CF)- left ventricular assist devices(LVAD).METHODS: We evaluated our institution's LVAD database and analyzed all patients who received a CF LVAD as a bridge to transplant(BTT) or destination therapy from March 2006 until June 2014. We identified 200 patients, of which 179 were implanted with a Heart Mate II device(Thoratec Corp., Pleasanton, CA) and 21 received a Heartware HVAD(Heart Ware Inc., Framingham, MA).RESULTS: The mean age of our LVAD recipients was 59.3 years(range 17-81), 76%(152/200) were males, and 49% were implanted for the indication of BTT. The survival rate for our LVAD patients at 30 d, 6 mo, 12 mo, 2 years, 3 years, and 4 years was 94%, 86%, 78%, 71%, 62% and 45% respectively. The mean duration of LVAD support was 581 d(range 2-2595 d). Gastrointestinal bleeding(was the most common adverse event(43/200, 21%), followed by right ventricular failure(38/200, 19%), stroke(31/200, 15%), re exploration for bleeding(31/200, 15%),ventilator dependent respiratory failure(19/200, 9%) and pneumonia(15/200, 7%). Our driveline infection rate was 7%. Pump thrombosis occurred in 6% of patients. Device exchanged was needed in 6% of patients. On multivariate analysis, preoperative liver dysfunction, ventilator dependent respiratory failure, tracheostomy and right ventricular failure requiring right ventricular assist device support were significant predictors of post LVAD survival.CONCLUSION: Short and long term survival for patients on LVAD support are excellent, although outcomes still remain inferior compared to heart transplantation. The incidence of driveline infections, pump thrombosis and pump exchange have declined significantly in recent years. | Athanasios Tsiouris Gaetano Paone Hassan W Nemeh Jamil Borgi Celeste T Williams David E Lanfear Jeffrey A Morgan | 2015 | World Journal of Cardiology2015，7，11： | 5 |
| 2 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 3 | Evaluation and treatment of internal impingement of the shoulder in overhead athletes显示文摘One of the most common pathologic processes seen in overhead throwing athletes is posterior shoulderpain resulting from internal impingement. 'Internal impingement' is a term used to describe a constellation of symptoms which result from the greater tuberosity of the humerus and the articular surface of the rotator cuff abutting the posterosuperior glenoid when the shoulder is in an abducted and externally rotated position. The pathophysiology in symptomatic internal impingement is multifactorial,involving physiologic shoulder remodeling,posterior capsular contracture,and scapular dyskinesis. Throwers with internal impingement may complain of shoulder stiffness or the need for a prolonged warm-up,decline in performance,or posterior shoulder pain. On physical examination,patients will demonstrate limited internal rotation and posterior shoulder pain with a posterior impingement test. Common imaging findings include the classic 'Bennett lesion' on radiographs,as well as articular-sided partial rotator cuff tears and concomitant SLAP lesions. Mainstays of treatment include intense non-operative management focusing on rest and stretching protocols focusing on the posterior capsule. Operative management is variable depending on the exact pathology,but largely consists of rotator cuff debridement. Outcomes of operative treatment have been mixed,therefore intense non-operative treatment should remain the focus of treatment. | Keith T Corpus Christopher L Camp David M Dines David W Altchek Joshua S Dines | 2016 | World Journal of Orthopedics2016，7，12： | 2 |
| 4 | Differential diagnosis in patients with suspected bile acid synthesis defects显示文摘AIM: To investigate the clinical presentations associated with bile acid synthesis defects and to describe identification of individual disorders and diagnostic pitfalls. METHODS: We describe semiquantitative determination of 16 urinary bile acid metabolites by electrospray ionization-tandem mass spectrometry. Sample preparation was performed by solid-phase extraction. The total analysis time was 2 min per sample. We determined bile acid metabolites in 363 patients with suspected defects in bile acid metabolism. RESULTS: Abnormal bile acid metabolites were found in 36 patients. Two patients had bile acid synthesis defects but presented with atypical presentations. In 2 other patients who were later shown to be affected by biliary atresia and cystic fibrosis the profile of bile acid metabolites was initially suggestive of a bile acid synthesis defect. Three adult patients suffered from cerebrotendinous xanthomatosis. Nineteen patients had peroxisomal disorders, and 10 patients had cholestatic hepatopathy of other cause. CONCLUSION: Screening for urinary cholanoids should be done in every infant with cholestatic hepatopathy as well as in children with progressive neurological disease to provide specific therapy. | Dorothea Haas Hongying Gan-Schreier Claus-Dieter Langhans Tilman Rohrer Guido Engelmann Maura Heverin David W Russell Peter T Clayton Georg F Hoffmann Jürgen G Okun | 2012 | World Journal of Gastroenterology2012，18，10： | 2 |
| 5 | Diverticulitis in California from 1995 to 2006: Increased Rates of Treatment for Younger Patients显示文摘 | Etzioni David A Cannom Rebecca R Ault Glenn T Beart Robert W Kaiser Andreas M | 2009 | The American Surgeon2009，，10： | 1 |
| 6 | Late Glacial temperature and precipitation changes in tile lowland Neotropics by tandem measurement of lSO in biogenic carbonate and gypsum hydration water显示文摘 | DAVID A H ALEXANDRA V T CAMILLA J W | 2012 | Geochimica et Cosmochimica Acta2012，77，： | 1 |
| 7 | Laboratory meas- urement of compaction-induced permeability change in porous rocks: Implications for the generation and maintenance of pore pressure excess in the crust显示文摘 | David C Wong T F Zhu W | 1994 | Pure and Applied Geophysics1994，143，： | 1 |
| 8 | Multiresonance design of a tonpilz transducer using the finite element method 显示文摘 | DAVID W H GOUGH P T | 1996 | IEEE Trans action Ultrason Ferroelect Frequency Control1996，43，5： | 1 |
| 9 | Origin and evolution of japanese encephalitis virus in Southeast Asian 显示文摘 | SOLOMON T NI Hao-lin DAVID W C | 2003 | J Virology2003，77，： | 1 |
| 10 | Dynamic response of layered structures subject to blast effects of non-nuclear weaponry显示文摘 | JOHN R H DAVID J R | 1987 | Computers and Structures1987，26，12： | 1 |
| 11 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 12 | Support Vector Data Description显示文摘 | David M J T Robert P W D | 2004 | Journal of Machine Learning Research2004，54，1： | 1 |
| 13 | Enabling scalable spectral clustering for image segmentation显示文摘 | Frederick T Alexander W David A C | 2010 | Pattern Recognition2010，43，12： | 1 |
| 14 | Origin and evolution of Japanese encephalitis virus in southeast asia显示文摘 | Solomon T Ni H L David W C Beasley | 2003 | J Virol2003，77，5： | 1 |
| 15 | Residual strength prediction of damaged composite fuselage panel with R-curve method 显示文摘 | Wang John T Poe Clarence C Jr Ambur Damodar R Sleight David W | 2006 | Composites Science and Technology2006，66，13： | 1 |
| 16 | Uniform Object Generation for Optimizing One-class Classifiers显示文摘 | David M J T Robert P W D | 2001 | Journal of Machine Learning Research2001，51，2： | 1 |
| 17 | Structural insights into the mechanical regulation of molecular in Biotechnology显示文摘 | WENDY E T Trends DAVID W C | 2001 | recognition sites2001，19，10： | 1 |
| 18 | Performance analysis of a feasible air-cycle refrigeration system for road transport 显示文摘 | Stephen W T Spence W John Doran David Wart | 2005 | International Journal of Refrigeration2005，，28： | 1 |
| 19 | Comparison of Total Hip Arthroplasty performed with and without cement:a randomized trial显示文摘 | Andreas L Robert B Cecil Ik David F Peter T Cindy W | 2002 | J Bone Joint Surg Am2002，84，10： | 1 |
| 20 | Molecular characterization of the first Austrilian isolation of Japanese encephalitis virus显示文摘 | David T Wang L F Peter W | 2000 | The FU Srain2000，81，： | 1 |
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