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| 1 | FK506对实验性卒中疗效的系统评价和Meta分析显示文摘FK506是治疗急性卒中的一种候选用药。决定一种药物是否可以用于临床试验,应当以全面的、无偏倚的动物实验数据的评估为依据,同时还应考虑到这些数据的局限性。这种评估不但应包括药物疗效,而且也应包括药效在体内的特征和局限性。本研究应用系统评价和Meta分析的方法对FK506在卒中动物模型中保护作用的证据进行评价。总共纳入了29个描述了实验步骤的研究,包括1759只动物。结果显示,FK506疗效的点估计值(结局指标的改善)是31.3%[95%CI(0.272-0.354)]。在采用氯胺酮麻醉和短暂性脑缺血的动物实验中,FK506的疗效更高,在使用大鼠,合并其他疾病的动物及仅以梗死面积为疗效指标的实验中,FK506疗效较低。已发表的实验研究质量均接近临床试验标准,但在高质量的研究中,FK506的疗效较低。FK506在实验性脑卒中的研究中,虽然显示出有明显的疗效,但是应注意由于研究质量和可能的发表偏倚等冈素的影响,FK506的疗效可能被过高估计。 | Malcolm R Macleod Tori O’Collins Laura L Horky David W Howells Geoffrey A Donnan 段建钢 | 2006 | 中国循证医学杂志2006，6，6： | 3 |
| 2 | DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate显示文摘 | Mary Premenko-Lanier Paul A Rota Gary Rhodes David Verhoeven Dan H Barouch Nicholas W Lerche Norman L Letvin William J Bellini Michael B McChesney | 2003 | Virology2003，，1： | 2 |
| 3 | The carbon we do not see-the impact of low molecular weight compounds on carbon dynamics and respiration in forest soils:a review显示文摘 | PATRICK A W DAVID L J FINLAY R | 2005 | Soil Biology & Biochemistry2005，37，： | 1 |
| 4 | Optical-cell evidencefor superheated ice under gas-hydrate-forming Conditions显示文摘 | STERN L A DAVID L H DURHAM W B | 1998 | Journal of Physical Chemistry1998，102，： | 1 |
| 5 | Removel of algal-derived organic material by preozona- tion and coagulation:monitoring changes in or- ganic quality by Pyrolgsis - GC - MS 显示文摘 | David L W Kimberly A G Kim S M | 1996 | Wat Res1996，30，11： | 1 |
| 6 | Slrong Negative ThermalExpansion in the Siliceous Zeolites ITQ-1 , ITQ-3 and SSZ-23 显示文摘 | David A W Philip L Paul A W | 1999 | joumaf of Materials Chemistry''1999，9，： | 1 |
| 7 | The distribution of dissolved DNA in an oligotrophic and a eutrophic river of southwest Florida 显示文摘 | Paul J H Cazares L H David A W | 1991 | Hydrobiologia1991，218，1： | 1 |
| 8 | Optical - cell Evidence for Su- perheated Ice under Gas -hydrate -forming Conditions显示文摘 | Stem L A David L H Durham W B | 1998 | Phys Chem B1998，102，： | 1 |
| 9 | Preparation of conjugated linoleic acid from safflower oil显示文摘 | Antoni A W Catherine J F | 1999 | JAOCS1999，76，6： | 1 |
| 10 | Myogenin,a factor regulating myogenesis,has a domain homologous to MyoD显示文摘 | Woodering E W David A S Victor K L | 1989 | Cell1989，56，4： | 1 |
| 11 | Seasonal and Inter-Annual Relationships Between Vegetation and Climate in Central New Mexico, USA显示文摘 | JEREMY L W DAVIDS S G JULIA E A | 2004 | Journal of Arid Environments2004，57，4： | 1 |
| 12 | An EOQ model with partial delayed payment and partial backordering显示文摘 | Taleizadeh A A David W P Mohammad S L | 2013 | Omega2013，41，2： | 1 |
| 13 | CLIPPERS: Induction and maintenance of remission using hydroxychloroquine显示文摘 | BOON L MARC A DAVID W | 2015 | Neurol Neuroimmunol Neuroinflamm2015，2，1： | 1 |
| 14 | Responses of bacterioplankton and phytoplankton to organic carbon and inorganic nutrient additions in contrasting oceanic ecosystems 显示文摘 | DAVID A CARON E L L ROBERT W | 2000 | Aquatic Microbial Ecology2000，22，2： | 1 |
| 15 | The effect of heat, cold, and prolonged storage on a granulosis virus of Pieris rapae显示文摘 | DAVID W A L GARDINER B O C | 1967 | J Invertebr Pathol1967，9，： | 1 |
| 16 | Mitochondrial H^sub 2^O^sub 2^ emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans显示文摘 | Anderson Ethan J Lustig Mary E Boyle Kristen E Woodlief Tracey L Kane Daniel A Lin Chien-Te Rice Jesse W Kang Li Rabinovitch Peter S Szeto Hazel H Houmard Joseph A Cortright Ronald N Wasserman David H Neufer P Darrell | 2009 | Journal of Clinical Investigation2009，，3： | 1 |
| 17 | Missile Autopilot Design Using a Gain Scheduling Technique显示文摘 | David P W Jason G W Douglas A L | 1994 | IEEE1994，，10： | 1 |
| 18 | A first-principles approach to understanding the Internet's router-level topology显示文摘 | LUN L DAVID A WALTER W | 2004 | ACM SIGCOMM Computer Communication Review2004，34，4： | 1 |
| 19 | Understanding Internet Topology:Principles,Models,and Validation显示文摘 | DAVID A LUN L WALTER W | 2005 | IEEE/ACM TransactionsonNetworking2005，13，： | 1 |
| 20 | Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis显示文摘AIM To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated cirrhosis.METHODS One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence(Morisky Medication Adherence Scale), beliefs surrounding medications(Beliefs about Medicines Questionnaire), perceptions of illness and medicines(Brief Illness Perception Questionnaire), and quality of life(Chronic Liver Disease Questionnaire) were examined. Clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = 0.05.RESULTS Medication adherence was ' High ' in 42 % o f participants, 'Medium' in 37%, and 'Low' in 21%. Compared to patients with 'High' adherence, those with 'Medium' or 'Low' adherence were more likely to report difficulty affording their medications(P < 0.001), lower perception of treatment helpfulness(P = 0.003) and stronger medication concerns relative to medication necessity beliefs(P = 0.003). People with 'Low' adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain(P = 0.023), shortness of breath(P = 0.030), and emotional disturbances(P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs(Necessity-Concerns Differential ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as independent predictors of 'Low'adherence.CONCLUSION The association between 'Low' adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explored further given the clinical relevance. | Kelly L Hayward Patricia C Valery Jennifer H Martin Antara Karmakar Preya J Patel Leigh U Horsfall Caroline J Tallis Katherine A Stuart Penny L Wright David D Smith Katharine M Irvine Elizabeth E Powell W Neil Cottrell | 2017 | World Journal of Gastroenterology2017，23，40： | 1 |
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