维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

11篇 您的检索式：作者名="DAWN J H"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis.	Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic	2019	Cellular & Molecular Immunology2019，16，2：	2
	2	Modified self-consistent nonlinear simulation of cyclotron autoresonance maser amplifiers显示文摘	Dawn T Y Chien H C Chen J M	1998	Phys Plasmas1998，，5：	1
	3	Measuring the positive side of the workfamily interface: Development and validation of a workfamily enrichment scale显示文摘	Dawn S Carlson D S Kacmar K M Wayne H J Grxywacz G J	2006	Journal of vocational behavior2006，68，1：	1
	4	Genetic linkage studies显示文摘	DAWN TEARE M BARRETT J H	2005	Lancet2005，366，：	1
	5	Minimally Invasive Esophagectomy: Esophagogastric Anastomosis Using the Transoral Orvil for the End- to-Side Ivor-Lewis Technique显示文摘	Bernadette U L Kristi L H Dawn E J	2009	Innovations2009，4，6：	1
	6	Minimally Invasive Esophagectomy:Esophagogastric AnastomosisUsing the TransoralOrvil for the Endto-Side Ivor-Lewis Technique显示文摘	Bernadette U L Kristi L H Dawn E J	2009	Innovations2009，4，6：	1
	7	Childrens' s Ocular Components and Age, Gender, and Ethnicity 显示文摘	Daniel J T Lynn G M Dawn H M	2009	Optom Vis Sci2009，86，8：	1
	8	Genetic linkage studies 显示文摘	DAWN TEARE M BARRETT J H	2005	Lancet2005，366，9490：	1
	9	Variation in Care in Pediatric Crohn Disease显示文摘	Richard B Colletti Robert N Baldassano David E Milov Peter A Margolis Athos Bousvaros Wallace V Crandall Karen D Crissinger Michael A D?Amico Andrew S Day Lee A Denson Marla Dubinsky Dawn R Ebach Edward J Hoffenberg Howard A Kader David J Keljo Ian H Leib	2009	Journal of Pediatric Gastroenterology and Nutrition2009，，3：	1
	10	A survey of energy policy priorities in the United States:Energy supply se- curity, economics, and the environment显示文摘	Dawn M Valeria H Matthew J	2014	Energy Policy2014，，60：	1
	11	Efficient Genetic Algorithms for Training Layered Feedforward Neural Networks 显示文摘	BYUNGJOO Y DAWN J H	1994	Information Sciences1994，76，：	1

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费