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| 1 | Pancreatic cancer serum biomarker PC-594:Diagnostic performance and comparison to CA19-9显示文摘AIM:To investigate serum PC-594 fatty acid levels as a potential biomarker in North American pancreatic cancer(PaC) patients,and to compare its performance to CA19-9.METHODS:Using tandem mass spectrometry,we evaluated serum PC-594 levels from 84 North American patients with confirmed PaC and 99 cancer-free control subjects.We determined CA19-9 levels by ELISA.Significance between Pa C patients and controls,and association with clinical variables was determined by analysis of variance and t-tests.Diagnostic performance was evaluated by receiver-operator characteristic(ROC)curve analysis,and PC-594 correlation with age and CA19-9 determined by regression analysis.RESULTS:Mean PC-594 levels were 3.7 times lower in Pa C patients compared to controls(P < 0.0001).The mean level in PaC patient serum was 0.76 ± 0.07 μmol/L,and the mean level in control subjects was 2.79 ± 0.15 μmol/L.There was no correlation between PC-594 and age,disease stage or gender(P > 0.05).Using 1.25 μmol/L as a PC-594 threshold produced a relative risk(RR) of 9.4(P < 0.0001,95%CI:5.0-17.7).The area under the receiver-operator characteristic curve(ROCAUC) was 0.93(95%CI:0.91-0.95) for PC-594 and 0.85(95%CI:0.82-0.88) for CA19-9.Sensitivity at 90% specificity was 87% for PC-594 and 71% for CA19-9.Six Pa C patients with CA19-9 above 35 U/m L showed normal PC-594 levels,while 24 Pa C patients with normal CA19-9 showed low PC-594 levels.Eighty-five of the 99 control subjects(86%) showed normal levels of both markers.CONCLUSION:PC-594 biomarker levels are significantly reduced in North American Pa C patients,and showed superior diagnostic performance compared to CA19-9. | Shawn A Ritchie Bassirou Chitou Qingan Zheng Dushmanthi Jayasinghe Wei Jin Asuka Mochizuki Dayan B Goodenowe | 2015 | World Journal of Gastroenterology2015，21，21： | 3 |
| 2 | Kinetics of cyto- kine production experimental systemic lupus erythematosus:in- volvement of Thelper cell 1/T helper cell 2- type cytokines in disease显示文摘 | SEGAL R BERMAS B L DAYAN M | 2007 | Immunology2007，158，6： | 1 |
| 3 | Intracellular delivery mediated by an ethosomal carrier显示文摘 | Touitou E Godin B Dayan N | 2001 | Biomaterials2001，22，： | 1 |
| 4 | Coronary calcium score, albuminuria and inflammatory markers in type 2 diabetic patients :associations and prognostic implications显示文摘 | Dayan A Narin B Biteker M | 2012 | Diabetes Res Clin Pract2012，98，1： | 1 |
| 5 | Comparison of the rapeutic effects of sodium hyaluronate and corticosteroid injections on trapeziometacarpal joint osteoarthritis显示文摘 | Bahadir C Onal B Dayan VY | 2009 | Clinical Rheumatology2009，，5： | 1 |
| 6 | Coronary calcium score, albuminuria and inflammatory markers in type 2 diabetic patients: associations and prognostic implications 显示文摘 | Dayan A Narin B Biteker M | 2012 | Diabetes Res Clin Pract2012，98，1： | 1 |
| 7 | Phytotoxicity of quassinoids : Physi- ological responses and structural requirements显示文摘 | Dayan F E Watson S B Galindo J C G Herndndez A D J McChesney J D Duke S O | 1999 | Pesticide Biochemistry and Physiology1999，65，1： | 1 |
| 8 | The wake-sleep algorithm for self-organizing neural networks显示文摘 | G E Hinton P Dayan B Frey R Neal | 1995 | Science1995，268，： | 1 |
| 9 | EPSPS gene amplification in glyphosate‐resistant Italian ryegrass ( Lolium perenne ssp. multiflorum ) from Arkansas显示文摘 | Reiofeli A Salas Franck E Dayan Zhiqiang Pan Susan B Watson James W Dickson Robert C Scott Nilda R Burgos | 2012 | Pest. Manag. Sci2012，，9： | 1 |
| 10 | Intracellular delivery mediated by an ethosomal carrier 显示文摘 | TOUITOU E GODIN B DAYAN N | 2001 | Biomaterials2001，22，22： | 1 |
| 11 | Intracellular delivery mediated by an ethosomal carrier显示文摘 | TOUITOU E GODIN B DAYAN N | 2001 | Biomaterial2001，22，22： | 1 |
| 12 | Intracellular delivery mediated by an ethosomal carrier 显示文摘 | Touitou E Godin B Dayan N | 2001 | Biomaterials2001，22，22： | 1 |
| 13 | Endometrial carcinoma in the south of Israel:Study of 231 cases显示文摘 | Piura B Bar Dayan A Cohen Y | 1997 | J Surg Oncol1997，66，： | 1 |
| 14 | Intracellular delivery mediated by an ethosomal carrier显示文摘 | Touitou E Godin B Dayan N | 2001 | Biomaterials2001，22，22： | 1 |
| 15 | Intracellular delivery mediated by an ethosomal carrier显示文摘 | Touitou E Crodln B Dayan N | | 0，，22： | 1 |
| 16 | Reward, motivation, and reinforcement learning: Review显示文摘 | Dayan P Balleine B W | 2002 | Neuron2002，36，2： | 1 |
| 17 | Intracellular delivery mediated by an ethosomal carrier 显示文摘 | Touitou E Godin B Dayan N | 2001 | Biomaterials2001，22，22： | 1 |
| 18 | Reactions offuel-nitrogen compounds under conditions of inertpyrolysis 显示文摘 | Axworthy A E Dayan V H Martin G B | 1978 | FueU1978，57，1： | 1 |
| 19 | Reaction of fuel-nitrogen compounds under conditions of inert pyrolysis显示文摘 | Axworthy A E Dayan V H Martin B G | 1978 | Fuel1978，57，1： | 1 |
| 20 | What does transient global amnesia really mean? Review of the literature and thorough study of 142 cases 显示文摘 | Quinette P Guillery-Girard B Dayan J | 2006 | Brain2006，129，7： | 1 |
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