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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Effect of soil moisture and fertilization on Perola pineapple in Coastal Tableland areas of Brazil 显示文摘 | Souza L F D de Almeida O A Caldas R C | 2002 | Tropical Agriculture2002，79，2： | 1 |
| 3 | Fuzzy Kohonen Clustering Networks for Interval Data显示文摘 | de Almeida C W D de Souza R M C R Candeias A L B | | 0，，01： | 1 |
| 4 | Group decision-making for leakage management strategy of water network显示文摘 | Morais D C de Almeida A T | 2007 | Resour Conserva Recycl2007，52，2： | 1 |
| 5 | Effect of Microstructural Parameters on the Mechanical Properties of Eutectoid Rail Steels 显示文摘 | GOMES M D G M D F DE ALMEIDA L H GOMES L C F C | 1997 | Materials Characterization1997，39，1： | 1 |
| 6 | Atmospheric distribution of organic compounds from urban areas near a coal-fired power station 显示文摘 | Moreira dos Santos C Y De Almeida Azevedo D De Aquino Nero F R | 2004 | Atmospheric Environment2004，38，9： | 1 |
| 7 | Adaptive Fuzzy Controller for Efficiency Optimization of In-duction Motors显示文摘 | De Almeida Souza D de Aragao Filho W C P Sousa G C D | 2007 | IEEE Transactions on Industrial Electronics2007，54，4： | 1 |
| 8 | Atmospheric distribution of organic compounds from urban areas near a coal-fired power station 显示文摘 | Moreia dos Santos C Y De Almeida Azevedo D De Aquino Neto F R | 2004 | Atmospheric Environment2004，38，9： | 1 |
| 9 | Optimum generation control in wind parks when carrying out system operation requests显示文摘 | de ALMEIDA R G EDGARDO D C LOPES J A | 2006 | IEEE Trans on Power Systems2006，21，2： | 1 |
| 10 | Multiuser detection for uplink DS-CDMA amplify-and- forward relaying systems显示文摘 | de Almeida A L F Fernandes C A R Benevides da Costa D | 2013 | IEEE Signal Processing Letters2013，20，7： | 1 |
| 11 | Atmospheric distribution of organic compounds from urbanareas near a coal-fired power station 显示文摘 | Moreira dos Santos C Y de Almeida Azevedo D de Aquino NetoF R | 2004 | AtmosphericEnvironment’2004，38，9： | 1 |
| 12 | Identification and seasonal variation of atmospheric or ganic pollutants in Campos dos Goytacazes,Brazil显示文摘 | DE ALMEIDA AZEVEDO D DOS SANTOS C Y M DE AQUINO NETO F R | 2002 | Atmospheric Environment2002，36，14： | 1 |
| 13 | Dolabellane diterpenoids from the South Atlantic gorgonian convexella magelhaenica显示文摘 | Rojo de Almeida M T Siless G E Perez C D | 2010 | J Nat Prod2010，73，10： | 1 |
| 14 | Mesenchymal stem cells derived from human exfoliated deciduous teeth(SHEDs)induce immune modulatory profile in monocytederived dendritic cells显示文摘 | SILVA FDE S RAMOS R N DE ALMEIDA D C | 2014 | PLo S One2014，9，98： | 1 |
| 15 | Efficiency of different strategies to detect autoantibodies to extractable nuclear anti- gens显示文摘 | Almeida Gonzalez D Cabrera de Leon A Rodriguez Perez Medel C | 2010 | J Immunol Method2010，360，12： | 1 |
| 16 | Active tuberculosis in inflammatory bowel disease patients under treatment from an endemic area in Latin America显示文摘BACKGROUND There has been an increase in cases of inflammatory bowel disease(IBD)in recent years.There is also greater access and availability of immunosuppressive and biological agents,which increase the risk of opportunistic infection despite improving the quality of life and promoting mucosal healing.Tuberculosis(TB)remains a public health problem,and it has a high incidence in several countries.Therefore,knowledge of the risk of developing TB in patients with IBD is important.AIM To evaluate the risk of active TB in patients with IBD under treatment from an endemic area in Latin America.METHODS A standard questionnaire included demographic variables,clinical aspects of IBD disease,history of active TB during treatment,active TB characteristics and evolution,initial screening and results and time from the start of anti-tumor necrosis factor alpha(TNFα)to TB development.RESULTS Azathioprine,anti-TNFα and the combination of these two drugs were associated with a higher risk of active TB incidence.The TNFα blockers increased the relative risk of developing active TB compared to other treatments.All four multivariable models showed that the use of TNFα blockers alone or in combination with azathioprine was an important risk factor for the incidence of active TB.After adjustment for sex,age,type of IBD and latent TB,anti-TNFα with azathioprine increased the relative risk to 17.8 times more than conventional treatment.Late TB,which was diagnosed 3 mo after the start of anti-TNFα,was the most frequent.CONCLUSION Treatment with anti-TNFα increased the risk of active TB in IBD patients from an endemic area in Latin America.This risk was increased when anti-TNFα was combined with azathioprine.The time from the beginning of the treatment to the active TB diagnosis suggests a new TB infection. | Flora Maria Lorenzo Fortes Ney Boa Sorte Victor D Mariano Laila D Andrade Fernanda A Oliveira Monique CA Santos Claudia Ivanilda N dos Santos Catharina A Passos Mila P Pacheco Valdiana C Surlo Neogelia P de Almeida Jaciane AM Fontes Andrea M Pimentel Raquel Rocha Genoile Oliveira Santana | 2020 | World Journal of Gastroenterology2020，26，44： | 1 |
| 17 | Ther- mal barrier coating by electron beam - physical vapor deposition of zirconia co - doped with yttria and niobia 显示文摘 | Almeida D S de Cairo C A A Silva C R M | 2010 | J Aerosp Technol Manag2010，2，2： | 1 |
| 18 | Group decision-making for leakage management strategy of water network 显示文摘 | Morais D C de Almeida A T | 2007 | Resour Conserv Recy2007，52，2： | 1 |
| 19 | Atmospheric distribution of organic compounds from urban areas near a coal-fired power station显示文摘 | de ALMEIDA AZEVEDO D de AQUINO NETO F R | 2004 | Atmos Environ2004，38，9： | 1 |
| 20 | Characterization of major enzymes and genes involved in flavonoid and proanthocyanidin biosynthesis during fruit development in strawberry (Fragaria × ananassa) 显示文摘 | ALMEIDA J R M D'AMICO E PREUSS A CARBONE F de vos RIC C H DEIML B MOURGUES F PERROTYA G FISCHER T C BOVY A G MARTENS S ROSATI C | 2007 | Archives of Biochemistry and Biophysics2007，465，1： | 1 |
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