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| 1 | Liver transplantation and alcoholic liver disease:History,controversies,and considerations显示文摘Alcohol consumption accounts for 3.8% of annual global mortality worldwide, and the majority of these deaths are due to alcoholic liver disease(ALD), mainly alcoholic cirrhosis. ALD is one of the most common indications for liver transplantation(LT). However, it remains a complicated topic on both medical and ethical grounds, as it is seen by many as a 'self-inflicted disease'. One of the strongest ethical arguments against LT for ALD is the probability of relapse. However, ALD remains a common indication for LT worldwide. For a patient to be placed on an LT waiting list, 6 mo of abstinence must have been achieved for most LT centers. However, this '6-mo rule' is an arbitrary threshold and has never been shown to affect survival, sobriety, or other outcomes. Recent studies have shown similar survival rates among individuals who undergo LT for ALD and those who undergo LT for other chronic causes of end-stage liver disease. There are specific factors that should be addressed when evaluating LT patients with ALD because these patients commonly have a high prevalence of multisystem alcohol-related changes. Risk factors for relapse include the presence of anxiety or depressive disorders, short pre-LT duration of sobriety, and lack of social support. Identification of risk factors and strengthening of the social support system may decrease relapse among these patients. Family counseling for LT candidates is highly encouraged to prevent alcohol consumption relapse. Relapse has been associated with unique histopathological changes, graft damage, graft loss, and even decreased survival in some studies. Research has demonstrated the importance of a multidisciplinary evaluation of LT candidates. Complete abstinence should be attempted to overcome addiction issues and to allow spontaneous liver recovery. Abstinence is the cornerstone of ALD therapy. Psychotherapies, including 12-step facilitation therapy, cognitive-behavioral therapy, and motivational enhancement therapy, help support abstinence. Nutritional therapy helps to reverse muscle wasting, weight loss, vitamin deficiencies, and trace element deficiencies associated with ALD. For muscular recovery, supervised physical activity has been shown to lead to a gain in muscle mass and improvement of functional activity. Early LT for acute alcoholic hepatitis has been the subject of recent clinical studies, with encouraging results in highly selected patients. The survival rates after LT for ALD are comparable to those of patients who underwent LT for other indications. Patients that undergo LT for ALD and survive over 5 years have a higher risk of cardiorespiratory disease, cerebrovascular events, and de novo malignancy. | Claudio Augusto Marroni Alfeu de Medeiros Fleck Jr Sabrina Alves Fernandes Lucas Homercher Galant Marcos Mucenic Mario Henrique de Mattos Meine Guilherme Mariante-Neto Ajacio Bandeira de Mello Brandao | 2018 | World Journal of Gastroenterology2018，24，26： | 7 |
| 2 | Immunohistochemical expression of thymidylate synthase and prognosis in gastric cancer patients submitted to fluoropyrimidine-based chemotherapy显示文摘Objective: Adjuvant chemotherapy with 5-fluorouracil(5-FU) has been widely used in gastric cancer(GC)patients to prevent relapse after curative resection. 5-FU acts by inhibiting thymidylate synthase(TS), and high levels of TS correlate with resistance to treatment with fluoropyrimidines. The aim of this study was to evaluate the expression of TS in GC patients, and its relation with clinicopathological characteristics and prognosis in adjuvant chemotherapy with 5-FU.Methods: We retrospectively evaluated 285 patients who underwent D2-gastrectomy with curative intent. TS expression was determined by immunohistochemistry(IHC) in tumor cells by tissue microarray(TMA). TS level was evaluated according to the intensity and percentage of cells marked by a score system. Patients were divided in three groups according to their TS-score: negative, low and high.Results: TS expression was positive in 92.3% of GC. TS-high, TS-low and TS-negative were observed in46.3%, 46.0% and 7.7% of patients, respectively. High-TS GC were associated with older age(P=0.007), high neutrophil/lymphocyte ratio(P=0.048), well/moderately differentiated histology(P=0.001), intestinal Lauren type(P<0.001) and absence of perineural invasion(P=0.003). Among 285 patients, 133 stage Ⅱ/Ⅲ patients(46.7%)received chemotherapy with 5-FU. In survival analysis, TS-high was associated with worse disease-free survival(DFS) in stage Ⅲ GC patients who received 5-FU-based chemotherapy(P=0.007). Multivariate analysis revealed that total gastrectomy, poorly differentiated tumors and high TS-score were associated with worse DFS in stage Ⅲ GC patients.Conclusions: High TS-score in stage Ⅲ GC was associated with poor DFS in patients treated with fluoropyrimidine-based chemotherapy. | Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos ANDre Roncon Dias Sheila Friedrich Faraj Cinthya dos Santos Cirqueira EvANDro Sobroza de Mello Bruno Zilberstein Venancio Avancini Ferreira Alves Ulysses Ribeiro Jr | 2018 | Chinese Journal of Cancer Research2018，30，5： | 3 |
| 3 | Prognostic implications of tumor-infiltrating lymphocytes in association with programmed cell death ligand 1 expression in remnant gastric cancer显示文摘Objective:Remnant gastric cancer(RGC)is usually associated with a worse prognosis.As they are less common and very heterogeneous tumors,new prognostic and reliable determinants are required to predict patients’clinical course for RGC.This study aimed to investigate the tumor-infiltrating lymphocytes(TILs)and programmed cell death ligand 1(PD-L1)status as prognostic biomarkers in a cohort of patients with RGC to develop an immunerelated score.Methods:Patients with gastric cancer(GC)who underwent curative intent gastrectomy were retrospectively investigated.RGC resections with histological diagnosis of gastric adenocarcinoma were enrolled in the study.The risk score based on immune parameters was developed using binary logistic regression analysis.RGCs were divided into high-risk(HR),intermediate-risk(IR),and low-risk(LR)groups based on their immune score.The markers(CD3+,CD4+/CD8+T cells and PD-L1)were selected for their potential prognostic,therapeutic value,and evaluated by immunohistochemistry(IHC).Results:A total of 42 patients with RGC were enrolled in the study.The score based on immune parameters exhibited an accuracy of 79%[the area under the receiver operating characteristic curve(AUC)=0.79,95%confidence interval(95%CI),0.63-0.94,P=0.002],and the population was divided into 3 prognostic groups:10(23.8%)patients were classified as LR,15(35.7%)as IR,and 17(40.5%)as HR groups.There were no differences in clinicopathological and surgical characteristics between the three groups.In survival analysis,HR and IR groups had worse disease-free survival and overall survival rates compared to the LR group.In the multivariate analysis,lymph node metastasis and the immune score risk groups were independent factors related to worse survival.Conclusions:A scoring system with immune-related markers was able to distinguish prognostic groups of RGC associated with survival.Accordingly,tumor-infiltrating immune lymphocytes and PD-L1 status may serve as a potential prognostic biomarker for patients with RGC. | Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos André Roncon Dias Leonardo Cardili Rafael Dyer Rodrigues de Moraes Renan Ribeiro E Ribeiro Venancio Avancini Ferreira Alves Bruno Zilberstein Evandro Sobroza de Mello Ulysses Ribeiro Jr | 2022 | Chinese Journal of Cancer Research2022，34，6： | 1 |
| 4 | Foreign Direct Investment in Developing Countries and Growth: A Selective Survey显示文摘 | DE MELLO Jr | 1997 | The Journal of Development Studies1997，34，1： | 1 |
| 5 | Neonatal risk factors for respiratory morbidity during the first year of life among premature infants 显示文摘 | de Mello RR Dutra MV Ramos JR | 2006 | Sao Paulo Med J2006，124，2： | 1 |
| 6 | Dual role of glutamatergic neurotransmission on amyloid beta( 1-42 ) aggregation and neurotoxicity in embryonic avian retina显示文摘 | Louzada PR Jr Paula Lima AC de Mello FG | 2001 | Neurosci Lett2001，301，1： | 1 |
| 7 | Foreign direct investment-led growth:evidence from time series and panel data显示文摘 | DE MELLO JR LUIZ R | 1999 | Oxford Economic Papers1999，51，： | 1 |
| 8 | Foreign direct investment in developing countries and growth: A selective survey显示文摘 | de Mello Jr L R | 1997 | Journal of Development Studies1997，34，1： | 1 |
| 9 | Foreign Direct Investment in Developing Countries and Growth: A Selective Survey 显示文摘 | LUIZ R DE MELLO Jr | 1997 | The Journal of Developrnent Studies1997，34，： | 1 |
| 10 | Effect of temperature on fluidity of irrigation fluids 显示文摘 | de Freitas Fonseca M Andrade CM Jr de Mello MJ | 2011 | Br J Anaesth2011，106，1： | 1 |
| 11 | Identification of fly eggs using scanning electron microscopy for forensic investigations显示文摘 | Mendon a PM dos Santos-Mallet JR de Mello RP et ol | 2008 | Micron2008，39，7： | 1 |
| 12 | Calcancal tendon regions exhibit different MMP-2 activation after vertical jumping and treadmill running显示文摘 | De Mello Malheiro OC Giacomini CT Justulin LA Jr | 2009 | Anat Rec (Hoboken)2009，292，10： | 1 |
| 13 | Foreign direct investment-led growth:evi2 dence from time series and panel data显示文摘 | LUIZ R | 1999 | Oxford Economic Papers1999，51，： | 1 |
| 14 | Foreign direct investment led growth: Evidence from time series and panel data 显示文摘 | De Mello Jr Luiz R | 1999 | Oxford Economic Papers1999，51，： | 1 |
| 15 | Foreign direct investment led growth: evidence from time series and panel data 显示文摘 | DE MELLO LUIZ R JR | 1999 | Oxford Economic Papers1999，，51： | 1 |
| 16 | Foreign Direct Investment in Developing Countries and Growth:A Selective Survey 显示文摘 | LUIZ R DE MELLO Jr | 1997 | The Journal of Development Studies1997，34，1： | 1 |
| 17 | Foreign Direct Investment-led Growth:Evidence from Time Series and Panel Data显示文摘 | LR de Mello Jr | 1999 | Oxford Economic Papers1999，，1： | 1 |
| 18 | Isolated absence of the right pulmonary artery as a cause of massive hemoptysis显示文摘 | DE MELLO JUNIOR WT COUTINHO NOGUEIRA JR SANTOS M | 2008 | Interact Cardiovasc Thorac Surg2008，7，6： | 1 |
| 19 | Foreign Direct Investment -led Growth: Evidence from Time Series and Panel Data 显示文摘 | LR de Mello Jr | 1999 | Oxford Economic Papers1999，，51： | 1 |
| 20 | Foreign direct investment in developing countries and growth:a selective survey显示文摘 | De Mello Jr Luiz R | 1997 | The Journal of Development Studies1997，34，1： | 1 |
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