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| 1 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 2 | Modelling Impact of Dredging and Dumping in Ebb-Flood Channel Systems显示文摘For a channel-shoal system in a funnel-shaped basin the impact of dredging and dumping is investigated using a complex process-based model. First, the residual flow and sediment transport circulations are analysed for the channel-shoal pattern, which has emerged after a longterm model simulation. Results are compared to the Western Scheldt estuary, which forms the inspiration for this study. Subsequently, different dredge and dump scenarios are modelled, according to a conceptual model, in which ebb- and flood-channels and enclosed shoals form morphodynamic units (cells) with their own sediment circulation. Model results show that dumping sediment in a channel further reduces the channel depth and induces erosion in the opposite channel, which enhances tilting of the cross-section of the cell and eventually can lead to the degeneration of a multiple channel system into a single channel. The impact of different dredging and dumping cases agrees with results from a stability analysis. This means that this type of model applied to a realistic geometry can potentially be used for better prediction of the impact of human interventions. | HIBMA A WANG Z B STIVE M J F Vriend H J de | 2008 | Transactions of Tianjin University2008，14，4： | 2 |
| 3 | Robust adaptive asymptotic tracking of nonlinear systems with additive disturbance 显示文摘 | Cai Z de Queiroz M S Dawson D M | 2006 | 1EEE Transactions on Automatic Control2006，51，3： | 1 |
| 4 | Polymerization of ethylene: some aspects of metallocene cata- lyst stabilization under homogeneous and heterogeneous reac- tion conditions显示文摘 | de Freitas A J D dos Santos J H Z Meneghetti S M P | 2011 | J Appl Poiym Sci2011，119，5： | 1 |
| 5 | Online voltage stability monitoring显示文摘 | DE SOU ZA A C Z DE SOUZA J C S DA SILVA A M L | 2000 | IEEE Trans on Power Systems2000，15，4： | 1 |
| 6 | Formation of Self-Assembled Triple-Lay- ered Rotavirus-Like Particles (tlRLPs) by Constitutive Co-Expression of VP2, VP6, and VP7 in Stably Transfected High-Five Insect Cell Lines 显示文摘 | SHOJA Z TAGLIAMONTE M JALILVAND S MOLLAEI-KANDELOUS Y DE STRADIS A TORNESELLO M L BUONAGURO F M BUON- AGURO L | 2015 | J Med Virol2015，87，1： | 1 |
| 7 | The development of a plant based vaccine for measles显示文摘 | Webster DE Thomas M C Huang Z | 2005 | Vaccine2005，23，15： | 1 |
| 8 | High-performance liquid chromatographic determination of levodropropizine in human plasma with fluorometric detection显示文摘 | Tagliaro F Moffa M De Battisti Z | 1996 | J Chromatogr B Biomed Appl1996，685，1： | 1 |
| 9 | Changes in soil enzyme activities following additions of cyanobaeterial biomass and exopolysaccharide 显示文摘 | De Caire G Z De Carlo M S Palma R M | 2000 | Soil Biology & Biochemistry2000，32，： | 1 |
| 10 | A dynamic architectural plant model: simulating resource-dependent growth 显示文摘 | Yan H P Kang M Z de Reffye P | 2004 | Annals of Botany2004，93，： | 1 |
| 11 | Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy显示文摘AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic lesions.METHODS:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon tumors.eUBM was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM imaging.The ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM images.During image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall anatomy.During the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon wall.Once the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and eosin.Colon images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion progression.RESULTS:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and thus,only three were subjected to the third eUBM/colonoscopy imaging acquisition(the third time-point).eUBM was able to detect the four layers in healthy segments of colon:the mucosa(the first hyperechoic layer moving away from the mini-probe axis),followed by the muscularis mucosae(hypoechoic),the submucosa(the second hyperechoic layer)and the muscularis externa(the second hypoechoic layer).Hypoechoic regions between the mucosa and the muscularis externa layers represented lymphoid infiltrates,as confirmed by the corresponding histological images.Pedunculated tumors were represented by hyperechoic masses in the mucosa layer.Among the lesions that decreased in size between the first and third time-points,one of the lesions changed from a mucosal hyperplasia with ulceration at the top to a mucosal hyperplasia with lymphoid infiltrate and,finally,to small signs of mucosal hyperplasia and lymphoid infiltrate.In this case,while lesion regression and modification were observable in the eUBM images,colonoscopy was only able to detect the lesion at the first and second time-points,without the capacity to demonstrate the presence of lymphoid infiltrate.Regarding the lesions that increased in size,one of them started as a small elevation in the mucosa layer and progressed to a pedunculated tumor.In this case,while eUBM imaging revealed the lesion at the first time-point,colonoscopy was only able to detect it at the second time-point.All colonic lesions(tumors,lymphoid infiltrate and mucosal thickening)were identified by eUBM,while colonoscopy identified just76%of them.Colonoscopy identified all of the colonic tumors but failed to diagnose lymphoid infiltrates and increased mucosal thickness and failed to differentiate lymphoid infiltrates from small adenomas.During the observation period,most of the lesions(approximately67%)increased in size,approximately 14%remained unchanged,and 19%regressed.CONCLUSION:Combining eUBM with colonoscopy improves the diagnosis and the follow-up of mouse colonic lesions,adding transmural assessment of the bowel wall. | Rossana C Soletti Kelly Z Alves Marcelo AP de Britto Dyanna G de Matos Mnica Soldan Helena L Borges Joo C Machado | 2013 | World Journal of Gastroenterology2013，19，44： | 1 |
| 12 | Impacts in distribution grids due to the connection of distributed wind generation 显示文摘 | Bezerra U H Arnora M A B Cunha A M Z de | 2001 | Proc IEEE Porto Power Tech Conf2001，，： | 1 |
| 13 | Screening Botryosphaeria species for lipases:Production of lipase by Botryosphaeria ribis EC-01 grown on soybean oil and other carbon sources显示文摘 | Mwssias J M da Costa B Z de Lima V M G | 2009 | Enzyme and Microbial Technology2009，45，67： | 1 |
| 14 | Dacite genesis via both slab melting and differentiation: Petrogenesis of La Yeguada volcanic complex, Panama 显示文摘 | Defant M J Richerson M de Boer J Z | 1991 | Journal of Petrology1991，32，： | 1 |
| 15 | Disparate effects of angiontensin Ⅱantagonists and calcium channel blockers on albuminuria in experimental diabetes and hypertension:potential role of nephrin显示文摘 | Cao Z de Gasparo M | 2003 | J Hypertens2003，21，1： | 1 |
| 16 | Chanceconstrained programming approaches to technical efficienciesand inefficiencies in stochastic data envelopment analysis显示文摘 | W W COOPER H DEING Z M HUANG | 2002 | Journal of the Operational Research Society2002，53，12： | 1 |
| 17 | Selective linear dimerization of 1,3-butadiene by palladium compounds immobilized into 1-nbutyl-3-methyl imidazolium ionic liquids显示文摘 | Suarez P A Z de Souza R F | 1998 | Polym Bull1998，40，： | 1 |
| 18 | On-line voltage stability monitoring显示文摘 | de Souza A C Z de Souza J C S da Silva A M L | 2000 | IEEE Trans on Power Systems2000，15，4： | 1 |
| 19 | Recent results from experimental studies on laser–plasma coupling in a shock ignition relevant regime显示文摘 | P Koester L Antonelli S Atzeni J Badziak F Baffigi D Batani C A Cecchetti T Chodukowski F Consoli G Cristoforetti R De Angelis G Folpini L A Gizzi Z Kalinowska E Krousky M Kucharik L Labate T Levato R Liska G Malka Y Maheut A Marocchino P Nicolai T O’Dell | 2013 | Plasma Physics and Controlled Fusion2013，，12： | 1 |
| 20 | Gas phase hydrodechlorination of dichloromethane at low concentrations with palladium/carbon catalysts 显示文摘 | De Pedro Z M Gomez-Sainero L M Gonzalez-Serrano E | 2006 | Industrial and Engineering Chemistry Research2006，45，： | 1 |
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