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| 1 | Nanog and transcriptional networks in embryonic stem cell pluripotency显示文摘象 LIF, BMP 和 Wnt 那样的几个外来的信号能支持胚胎的茎(ES ) 的 theself 更新和 pluripotency 通过调整的房间“ pluripotentgenes。“一个唯一的 homeobox 抄写因素, Nanog,是这些信号的关键下游的受动器之一。Nanog 的提高的水平能维持老鼠 ES 细胞自强独立人士 ofLIF 并且没有喂入器饲料分送器细胞,启用人的 ES 细胞生长。除了外部信号,小径,象 FoxD3 那样的内在的抄写因素, P53 和 Oct4 也涉及调整 Nanog 的表示。机能上地, Nanog 和象 Oct4 和 Sox2 那样的另外的关键 pluripotentfactors 工作控制在 EScell pluripotency 有重要函数的一套目标基因。这些关键因素形成一个规章的网络支持或限制对方“ sexpression 铺平房间,它维持 ES 的性质。 | Guangjin Pan James A Thomson | 2007 | Cell Research2007，17，1： | 51 |
| 2 | Intestinal sugar transport显示文摘糖类是食谱的一个重要部件。我们摄取的糖类从简单单音的糖类(葡萄糖, fructose 和半乳糖)到 disaccharides (乳糖,蔗糖) 到复杂多糖。大多数糖类被消化由唾液并且胰淀粉酶,并且被酶进一步在 enterocytes 的刷状缘膜(BBM ) 划分成单音的糖类。例如, lactase-phloridzin 水疗院放射激光并且 sucrase-isomaltase 是涉及营养的水解作用的二 disaccharidases 结盟重要 disaccharides。一旦单音的糖类被介绍给 BBM,表示滋养的运输 ers 的成熟 enterocytes 搬运糖进 enterocytes。这篇论文考察贡献了肠的糖运输的一个工作模型的开发的早研究,并且详细说明在理解糖由全神贯注于肠的进程做的最近的进展。 | Laurie A Drozdowski Alan BR Thomson | 2006 | World Journal of Gastroenterology2006，12，11： | 13 |
| 3 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013显示文摘 | Marie Ng Tom Fleming Margaret Robinson Blake Thomson Nicholas Graetz Christopher Margono Erin C Mullany Stan Biryukov Cristiana Abbafati Semaw Ferede Abera Jerry P Abraham Niveen M E Abu-Rmeileh Tom Achoki Fadia S AlBuhairan Zewdie A Alemu Rafael Alfonso | 2014 | The Lancet2014，，： | 7 |
| 4 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 5 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 6 | Ontogeny,growth and development of the small intestine:Understanding pediatric gastroenterology显示文摘Throughout our lifetime,the intestine changes.Some alterations in its form and function may be genetically determined,and some are the result of adaptation to diet,temperature,or stress.The critical period programming of the intestine can be modified,such as from subtle differences in the types and ratios of n3:m6 fatty acids in the diet of the pregnant mother,or in the diet of the weanlings.This early forced adaptation may persist in later life,such as the unwanted increased intestinal absorption of sugars,fatty acids and cholesterol.Thus,the ontogeny,early growth and development of the intestine is important for the adult gastroenterologist to appreciate,because of the potential for these early life events to affect the responsiveness of the intestine to physiological or pathological challenges in later life. | Laurie A Drozdowski Tom Clandinin Alan BR Thomson | 2010 | World Journal of Gastroenterology2010，16，7： | 5 |
| 7 | Characterization and target identification of a DNA aptamer that labels pluripotent stem cells显示文摘 | Zhonggang Hou Susanne Meyer Nicholas E Propson jeff Nie Peng Jiang Ron Stewart James A Thomson | 2015 | Cell Research2015，25，3： | 5 |
| 8 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 9 | 减低剂量预处理的异基因造血干细胞移植治疗复发性侵袭性非霍奇金淋巴瘤患者获长期存活显示文摘 | Thomson KJ Morris EC Bloor A 景晶 来晓瑜 | 2009 | 中华移植杂志(电子版)2009，3，3： | 3 |
| 10 | Embryonic stem cell lines derived from human blastocysts 显示文摘 | Thomson J A Itskovitz Eldor J Shapiro S S | 1998 | Science1998，282，5391： | 2 |
| 11 | 文化、不平等性与卫生服务提供显示文摘1动态不平等性对基层医疗卫生人力的影响
政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，3： | 2 |
| 12 | Morphological,kinetic,membrane biochemical and genetic aspects of intestinal enteroplasticity显示文摘The process of intestinal adaptation('enteroplasticity') is complex and multifaceted.Although a number of trophic nutrients and non-nutritive factors have been identified in animal studies,successful,reproducible clinical trials in humans are awaited.Understanding mechanisms underlying this adaptive process may direct research toward strategies that maximize intestinal function and impart a true clinical benefit to patients with short bowel syndrome,or to persons in whom nutrient absorption needs to be maximized.In this review,we consider the morphological,kinetic and membrane biochemical aspects of enteroplasticity,focus on the importance of nutritional factors,provide an overview of the many hormones that may alter the adaptive process,and consider some of the possible molecular profiles.While most of the data is derived from rodent studies,wherever possible,the results of human studies of intestinal enteroplasticity are provided. | Laurie A Drozdowski M Tom Clandinin Alan BR Thomson | 2009 | World Journal of Gastroenterology2009，15，7： | 2 |
| 13 | Clonally derived human embryonic stem lines maintain plurpotency and proliferative potential for prolonged periods of culture显示文摘 | Thomson J A | 2000 | Dev Biol2000，227，： | 1 |
| 14 | Results of a multicenter randomized study to evaluate the safety and efficacy of combined immunotherapy with interleukin-2, interferon-{alpha}2b and histamine dihydrochloride versus dacarbazine in patients with stage Ⅳ melanoma 显示文摘 | Middleton M Hauschild A Thomson D | 2007 | Ann Oncol2007，18，10： | 1 |
| 15 | Fluoroscopically guided synechiolysis for patients with Asherman's syndrome : menstrual and fertility outcomes 显示文摘 | Thomson AM Abbott JA Kingston' A | 2007 | Fertil Steril2007，87，2： | 1 |
| 16 | Embryonic stem cell lines derived from human blastocysts 显示文摘 | THOMSON J A ITSKOVITZ-ELDOR J SHAPIRO S S | 1998 | Science1998，282，： | 1 |
| 17 | Results of a Summer Academy to Increase Minority Student Access to Allied Health and Other Health Professions显示文摘 | Thomson W A Denk J P Miller L M | 1991 | J Allied Health1991，21，1： | 1 |
| 18 | Analysis of uncertainties in instantaneous soot volume fraction measurements using two-dimensional, auto-compensat- ing, laser-induced incandescence (2D-AC-LⅡ) 显示文摘 | Crosland B M Johnson M R Thomson K A | 2011 | Appl PhysB2011，102，1： | 1 |
| 19 | Conceptualizing and measuring Collaboration 显示文摘 | Thomson A M PerryJ L Miller T K | 2009 | Journal of Public Administration Research and Theory2009，9，1： | 1 |
| 20 | Homologous recombination in human embryonic stem cells显示文摘 | Zwaka T P Thomson J A | 2003 | Nature Biotechnology2003，21，3： | 1 |
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