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| 1 | Neuroprotective effects of the immunodepressant FTY720 on caspase-3 expression and neural apoptosis in a rat model of acute spinal cord injury显示文摘BACKGROUND:Studies on the immunodepressant FTY720 have primarily focused on organ transplantation and autoimmune disease therapy.However,the effects on caspase-3 expression and neural apoptosis following acute spinal cord injury remain uncertain.OBJECTIVE:To elucidate the underlying mechanism of the immunodepressant FTY720 to alleviate spinal cord injury by inhibiting expression of caspase-3 and neural apoptosis.DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at Central Laboratory of the Second Affiliated Hospital of Dalian Medical University from April to July 2009.MATERIALS:FTY720 was provided by Wuhan Yuancheng Technology Developing,China.METHODS:A total of 120 Sprague Dawley rats were randomly assigned to sham-surgery,model,and FTY720 groups.Spinal cord injury at the T9-10 segment was induced in model groups using the free-fall method.Following establishment of spinal cord injury at the T9-10 segment in the FTY720 group,rats were treated with an intragastric injection of 0.3 mL saline-diluted FTY720 (3 mg/kg).MAIN OUTCOME MEASURES:At 6,12,24,48,and 72 hours following spinal cord injury,caspase-3 expression was detected using streptavidin-peroxidase immunohistochemistry,and neural apoptosis was detected using the TUNEL method.RESULTS:Positive caspase-3 expression and neural apoptosis was not observed in the sham-surgery group at the various time points.The number of apoptotic cells increased with time after acute spinal cord injury,peaked at 24 hours following injury,and then gradually reduced.However,neural apoptosis remained at a high level.Caspase-3 expression positively correlated with neural apoptosis (r=0.864,P < 0.05).Caspase-3 expression and neural apoptosis significantly decreased following FTY720 therapy (P < 0.05).CONCLUSION:FTY720 significantly reduced caspase-3 expression and neural apoptosis in a rat model of acute spinal cord injury. | Liang Yang Decheng Lü Lianjie Zheng Zhaohui Wang Kai Tang Wei Zhang Xiaotian Li | 2010 | Neural Regeneration Research2010，5，9： | 7 |
| 2 | Discovery and Geological Significance of Neoproterozoic Metamorphic Granite in Jimo, Shandong Province, Eastern China显示文摘During the 1:50000 regional geological survey in Jimo,east Shandong Province,Paleoproterozoic metamorphic supracrustal rocks and Neoproterozoic metamorphic plutonite were newly discovered. These rocks displayed inclusions which had occurred in the Mesozoic granite,and the main lithologies are schist,granulite,marble,and granitic gneiss. Geochemical analyses suggest that Neoproterozoic metamorphic plutonite are characterized by high-K,metaluminous to weakly peraluminous. They are enriched in LILE and depleted in HFSE,with moderately enrichment of LREE,weak fractionation of LREE from HREE and negative Eu anomalies. The surface age of plutonic rocks in the survey area is 770.2±2.4 Ma,representing the age of magma crystallization,which is agreement with the the Neoproterozoic magmatic event after Rodinia supercontinent in the northern margin of Southern China continental block. In addition,the age of sporadic distribution(298 Ma and 269 Ma) is mixed zircon age,representing the rocks experienced metamorphism in Indosinian period. According to the associated mineral assemblages,and the characteristic metamorphic minerals and temperature pressure conditions,four metamorphic facies were identified,including amphibolitic,epidote amphibolite,greenschist,and mid-high pressure greenschist. Analysis of tectonic setting suggests that granitic gneiss is formed in an extensional environment and was involved from the continental margin magmatic arc to intraplate environment. Jimo is distributed in the east of Zhuwu fault,and has the same Spatial distribution location with the Weihai uplift UHP metamorphic belt rocks. The metamorphic rocks in Jimo area have similar geochemical characteristics of elements,tectonic setting and retrograde metamorphism with that in the Sulu UHP metamorphic belt. Therefore,Zhuwu fault may be the boundary fault of Sulu UHP metamorphic belt. | ZHU Decheng Lü Dawei SHEN Xiaoli YANG Qing LI Dandan REN Tianlong YANG Shipeng | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 3 |
| 3 | Host gene regulation during Coxsachie virus B3 infection in mice:assessments by microarrays显示文摘 | Taylar L A Carthy C M Decheng Y | 2000 | Circ Res2000，87，： | 1 |
| 4 | Preparation and electrochemical characteris tics of LiNi1/3Co1/3Mn1/3O2 coated with metal oxides coating显示文摘 | DECHENG L YASUHIRO K KOICHI K NOGUCHI H SATO Y | 2006 | Journal of Power Sources2006，160，： | 1 |
| 5 | 显示文摘 | Atsushi I Decheng L Yasuhiko O | 2008 | J Power Sources2008，183，： | 1 |
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