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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro显示文摘 | Lian G Wang C Teng C Zhang C Du L Zhong Q Miao C Ding M Deng H | 2006 | 中国生物学文摘2006，20，5： | 11 |
| 3 | 柑桔黄龙病的鉴定和柯赫氏定理(英文)显示文摘黄龙(梢)病被认为是世界柑橘生产上的毁灭性病害已超过一个世纪,但该病害的病原学至今还没有清晰地建立起来。根据16S rRNA基因序列分析,一组被称为'Candidatus Liberibacter species'的难培养细菌被认为与黄龙病相关。然而,要确定'Ca.Liberibacter spp.'是黄龙病病原的柯赫氏定理并没有真正完成。令我们担忧的是,近年来有些文献频频指出'Ca.Liberibacter spp.'是黄龙病的病原,其实该细菌与柑橘寄主的直接病理反应还没有完全确定。我们建议,在黄龙病病原学清楚之前,文献报道在这方面需要有准确的阐述。 | Chen J Deng X Civerolo E L Lee R F Jones J B Zhou C Hartung J S Manjunath K L Brlansky R H | 2011 | 植物病理学报2011，41，2： | 10 |
| 4 | Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue显示文摘 | Deng W Han Q Liao L Li C Ge W Zhao Z You S Deng H Murad F Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 5 | A 2940 nm factional photothermolysis laser in the treatment of acne scarring:a pilot study in China显示文摘 | DENG H YUAN D YAN C | 2009 | J Drugs Dermatol2009，8，11： | 1 |
| 6 | Fuzzy multicriteria analysis for performance evaluation of bus companies显示文摘 | Yeh C H Deng H Chang Y H | 2000 | European Journal of Operational Research2000，126，： | 1 |
| 7 | Factors affecting Agrobactcrium-mediated transformation and regeneration of sweet orange and citrange 显示文摘 | Yu C H Huang S Chen C X Deng Z A Ling P and Gmitter F O J | 2002 | Plant Cell Tissue and Organ Culture2002，71，： | 1 |
| 8 | Multiplc functional groups of varying ratios in metal-organic frameworks 显示文摘 | Deng H X Doonan C J Furukawa H | 2010 | Science2010，327，： | 1 |
| 9 | Breaking and improving an image encryption scheme based on total shuffiing scheme显示文摘 | ZHU C X LIAO C L DENG X H | 2013 | Nonlinear Dynamics2013，71，12： | 1 |
| 10 | Large-pore apertures in a series of metal-organic frameworks显示文摘 | Deng H Grunder S Cordova K E Valente C Furukawa H Hmadeh M Gandara F Whalley A C Liu Z Asahina S Kazumori H O'Keeffe M Terasaki O Stoddart J F Yaghi O M | 2012 | Science2012，336，： | 1 |
| 11 | Diabetes as a risk fac- tor for dementia and mild cognitive impairment: A meta- analysis of longitudinal studies显示文摘 | Cheng G Huang C Deng H | 2012 | Intern Med J2012，42，5： | 1 |
| 12 | Inter-company comparison using modified TOPSIS with objective weights显示文摘 | H DENG C H YEH R J WILLIS | | 0，，04： | 1 |
| 13 | Kernel based data fusion improves the drug-protein interaction prediction显示文摘 | Wang Y C Zhang C H Deng N Y | | 0，，06： | 1 |
| 14 | Development of pressurized hot water extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry for determinaction of ligustilides in Ligusticum chuanxiong and Angelica sinensis显示文摘 | Deng C H Jie J Wang X C | 2005 | J Sep Sci2005，28，11： | 1 |
| 15 | Diabetes as a risk factor for demen- tia and mild cognitive impairment:a meta-analysis of longitudinal studies 显示文摘 | Cheng G Huang C Deng H | 2012 | Intern Med J2012，42，5： | 1 |
| 16 | Production of duck-chicken chimeras by transferring early blastoderm cells (abstract) 显示文摘 | LI Z D DENG H LIU C H | 1999 | Trans Res1999，8，： | 1 |
| 17 | Superparamagnetic high-magnetization microspheres with an Fe3 O4 @ SiO2 core and perpendicularly aligned mesoporous SiO2 shell for removal of microcystins 显示文摘 | Deng Y H Qi D W Deng C H | 2008 | J Am Chem Soc2008，130，1： | 1 |
| 18 | Displacement back analysis for a steep slope at the Three Gorges project site显示文摘 | DENG J H LEE C F | 2001 | International Journal of Rock Mechanics & Mining Sciences2001，38，： | 1 |
| 19 | 显示文摘 | Deng C Rong G Z Tian H Y | 2005 | Polymer2005，46，： | 1 |
| 20 | Multiresponsive chiroptical switch of an azobenzene-containing lipid:solvent,temperature,and photoregulated supramolecular chirality显示文摘 | Duan P F Li Y G Li L C Deng J G Liu M H | 2011 | Journal of Physical Chemistry B2011，115，13： | 1 |
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