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您的检索式：作者名="DENG Xinshan"
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| 1 | Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-lH-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents显示文摘 | ZHANG Lan DENG Xinshan WU Jiaofeng MENG Guangpeng LIU Congchong CHEN Guzhou ZHAO Qingchun HU Chun | 2017 | Chemical Research in Chinese Universities2017，33，3： | 1 |
| 2 | Design,synthesis,and bioassay of 5-epi-aminoglycosides显示文摘For the purpose of seeking new antibiotics,researchers usually modify the already-existing ones.However,this strategy has been extensively used and is close to its limits,especially in the case of aminoglycosides,and it is difficult to find a proper aminoglycoside antibiotic for novel modification.In this paper,we reported the design,synthesis,and evaluation of a series of 5-epi-neamine derivatives based on the structural information of bacterial 16S RNA A-site binding with aminoglycosides.Bioassay results showed that our design strategy was feasible.Our study offers a new way to search for structurally novel aminoglycosides.Meanwhile,our study provides valuable structure-activity relationship information,which will lead to better understanding and exploitation of the drug target,and improved development of new aminoglycoside antibiotics. | YAN Ribai NIU Youhong LIU Yuheng DENG Junfeng YE Xinshan | 2022 | Chinese Journal of Natural Medicines2022，20，11： | 0 |
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