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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | The effect of magnetic field on ion hydration and sulfate scale formation显示文摘 | Igor B Silva Joao C Queiroz Neto Denise F S Petri | 2015 | Col- loids and Surfaces A: Physicochemical and Engineering Aspects2015，465，1： | 1 |
| 3 | The subjective dimension of social isolation: A qualitative investigation of older adults' experiences in small social support networks显示文摘 | DENISE C F | 2011 | Journal of aging studies2011，25，4： | 1 |
| 4 | A statistical comparison of protein and carbohydrate characterisation methodology applied on sewage sludge samples显示文摘 | JIMENEZ J VEDRENNE F DENIS C | | 0，，05： | 1 |
| 5 | Four triterpenoid saponins from dried roots of Gypsophila species显示文摘 | Denise F Bruno C Betrand M D S | 1991 | Phytochemistry1991，30，3： | 1 |
| 6 | Nanoparticles as vehicles fordelivery of photodynamic therapy agents 显示文摘 | Denise B Pierre C Celine F | 2008 | Trends inBiotechnology2008，26，11： | 1 |
| 7 | Satel ite cel s and myonuclei in young and elderly women and men显示文摘 | Kadi F Charifi N Denis C | | 0，，： | 1 |
| 8 | Displacement and load transfer mechanism of geogrids under pullout condition 显示文摘 | Ana Cristina C F Sieira Denise M S Gerscovich Alberto S F J Sayao | 2009 | Geotextiles and Geomembranes2009，27，4： | 1 |
| 9 | Displacement and load transfer mechanisms of geogrids under pullout condition显示文摘 | ANA CRISTINA C SIEIRA A F DENISE M S | 2009 | Geotextiles and Geomembranes2009，27，： | 1 |
| 10 | The lethality of Euphorbia conspicua to adults of Biomphalarla glabrata, cercaria of Schistosoma mansoni and larvae of Artemia salina 显示文摘 | Aldenir F dos Santos Denise P L de Azevedo Rosalina da C dos Santos Mata | 2007 | Bioresour Technol2007，98，1： | 1 |
| 11 | p63 and p73 are re-quired for p53-dependent apoptosis in response to DNA damage 显示文摘 | Elsa R F Kenneth Y T Denise C | 2002 | Nature2002，416，6880： | 1 |
| 12 | Displacement and Load Transfer Mechanisms of Geogrids Under Pullout Condition显示文摘 | Ana C C F S Denise M S G Alberto S F J S | 2009 | Geotextiles and Geomembranes2009，，27： | 1 |
| 13 | A prospective,randomized-control ed clinical trial to evaluate bone preservation using implants with different geometry placed into extraction sockets in the maxil a显示文摘 | Mariano S Denis C Jouge F | | 0，，： | 1 |
| 14 | Mitochondrial biogenesis during skeletal muscle regeneration显示文摘 | Duguez S Féasson L Denis C Freyssenet D | | 0，，： | 1 |
| 15 | A new brachial plexus block technique in dogs显示文摘 | FABIO F DENISE T F JOSE O C A J | 2002 | Veterinary Anaesthesia and Analgesia2002，29，： | 1 |
| 16 | The Content Validity Index: Are You Sure You Know What's Being Reported Critique and Rec- ommendations显示文摘 | Denise F Polit C Beck T | 2006 | Research in Nursing &Health2006，29，： | 1 |
| 17 | Is the CVI an Acceptable Indicator of Content Validity Appraisal and Recommendations 显示文摘 | Denise F Polit C Beck T Owen SV | 2007 | Research in Nursing& Health2007，30，： | 1 |
| 18 | The effect of NazO/SiOz molar ratio, curing temperature and age on compressive strength, morphology and microstructure of alkali- activited fly ash-based geopolymers显示文摘 | Alexandre Silva de Vargas Denise C C Dal Molin Antonio C F Cilela | 2011 | Cement Concrete composites2011，33，： | 1 |
| 19 | Hedging with the Nikkei index futures:The conventional model versus the error correction model显示文摘 | Chou W L Denis K K F Lee C F | | 0，，04： | 1 |
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