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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Effect of low-protein diet supplemented with Keto acids on progression of disease in patients with chronic renal failure显示文摘 | Deniz Am Agli M Ensari C | 2000 | Nephron2000，84，3： | 1 |
| 3 | Modeling and optimization IV:Investigation of reaction kinetics and kinetic constants using a program in which artificial neural network (ANN) was integrated显示文摘 | DENIZ B FAHRIYE C D ISMAIL H B | | 0，，： | 1 |
| 4 | ENCARA2:Realtime detection of multiple faces at different resolutions in video stream显示文摘 | CASTRILLON M DENIZ O GUERRA C | 2007 | Journal of Visual Communication and Image Representation2007，18，2： | 1 |
| 5 | Lgotioside:a new phenypropanoid glycoside from Lagotis stolonifera显示文摘 | IHSAN C DENIZ T ANTHONY D | 1991 | Helv Chim Acta1991，74，6： | 1 |
| 6 | Mild hypothermia improves survival during hemorrhagic shock without affecting bacterial translocation显示文摘 | Deniz T Agalar C Ozdogan M | 2009 | J Invest Surg2009，22，1： | 1 |
| 7 | Modeling andoptimization III:Reaction rate estimation using artificial neural network (ANN) without a kinetic mode显示文摘 | DENIZ B FAHRIVE C D ISMAIL H B | | 0，，： | 1 |
| 8 | Bidirectional switching of near IR emitting boradiazaindacene fluoro- phores显示文摘 | DENIZ E ISBASAR G C BOZDEMIR O A | 2008 | Org Lett2008，10，16： | 1 |
| 9 | Cyclooxygenase-2 expression and its association with angiogenesis, Helicobacter Pylori, and clinico-Pathologic characteistics Of gas- triecarcinoma 显示文摘 | Deniz Y Taha A Usur C | 2008 | Pathol Res Pract2008，204，8： | 1 |
| 10 | Lgotioside:a new phenypropanoid glycoside from Lagotis stolonifera显示文摘 | IHSAN C DENIZ T ANTHONY D | | 0，，06： | 1 |
| 11 | The effect of hypothermia on splanchnic flows and lung in a two-hit hemorrhagic shock model显示文摘 | Deniz T Agalar C Agalar F | 2010 | J Surg Res2010，158，1： | 1 |
| 12 | Spinal inflammation by magnetic resonance imaging in patients with ankylosing spondylitis:association with disease activity and outcome parameters显示文摘 | Sefika K Dilek K Deniz C | 2012 | Rheumatol Int2012，32，12： | 1 |
| 13 | The effects of electromagnetic fields on the ultrastructure of heart显示文摘 | Soker S Sert C Deniz M | 2011 | Int J Morphol2011，29，3： | 1 |
| 14 | Estimating shipping emissions in the region of the Sea of Marmara, Turkey 显示文摘 | DENIZ C DURMUSOGLU Y | 2008 | Science of the Total Environment2008，390，： | 1 |
| 15 | Phenylethanoid glycosides from Scutellaria galericulata显示文摘 | TAYFUN E DENIZ T IHSAN C | 2002 | Turk J Chem2002，26，4： | 1 |
| 16 | Effect of post-polymerization heat-treatments on degree of conversion,leaching residual MMA and in vitro cytotoxicity ofautopolymerizing acrylic repair resin显示文摘 | Bural C Aktas E Deniz G | 2011 | Dent Mater2011，27，8： | 1 |
| 17 | ENCARA2: Real- time Detection of Multiple Faces at Different Resolutions in Video Streams显示文摘 | Castrillon M Deniz O Guerra C | 2007 | Journal of Visual and Image Representa- tion2007，，： | 1 |
| 18 | Bio- mechanical evaluation of posterior thoracic transpedicular dis- cectomy laboratory investigation 显示文摘 | DENIZ F E BRASILIENSE L C LAZARO B R | 2010 | J Neurosurg Spine2010，13，2： | 1 |
| 19 | Morphological alterations in small intestine of rats with myenterie plexus denervation 显示文摘 | Deniz M Kilin c M Hatiposlu ES | 2004 | Eur Surg Res2004，36，3： | 1 |
| 20 | A new phenypropanoid glycoside from Lagotis stolonifera 显示文摘 | Ihsan C Deniz T Anthomy D W | 1991 | Helv Chim Acta1991，74，6： | 1 |
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