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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Polymeric proanthocyanidins are catabolized by human colonic microflora into low molecular-weight phenolic acids 显示文摘 | Deprez S Brezillon C Rabot S | 2000 | J Nutr2000，130，： | 3 |
| 3 | Sensitivity and accuracy of quantitative realtime polymerase chain reaction using SYBR green I depends on cDNA synthesis conditions 显示文摘 | LEKANNE DEPREZ R H FIJNVANDRAAT A C RUI JTER J M | 2002 | Analytical Biochemistry2002，307，： | 1 |
| 4 | Assumption-free analysis of quantitative real-time polymerase chain reaction(PCR)data显示文摘 | Ramakers C Ruijter JM Deprez RH | 2003 | Neurosci Lett2003，339，1： | 1 |
| 5 | A ZVS Imbricated Cell Multilevel Inverter with Auxiliary Resonant Commutated Poles 显示文摘 | Turpin C Deprez L Forest F | 2002 | Power Electronics IEEE Transactions on2002，17，6： | 1 |
| 6 | A novel GABRG2 mutation associated with febrile seizures显示文摘 | D Audenaert E Schwartz K G. Claeys L Claes L Deprez A Suls T Van Dyck L Lagae C Van Broeckhoven R L. Macdonald P De Jonghe | 2006 | Neurology2006，，4： | 1 |
| 7 | A case report of desmoid tumor of the finger显示文摘 | Berthe JV Lorea P Deprez C | 2003 | Chit Main2003，22，6： | 1 |
| 8 | Prospective randomized comparison between EMR and ESD for endoscopic removal of superficial esophageal cancer 显示文摘 | Deprez P H Yeung R C Aouattah T | 2008 | Gastrointest Endosc2008，67，5： | 1 |
| 9 | Cholestatic syndrome due to preservation injury after liver transplantation显示文摘 | Adler M Deprez C Rickaert F | 1988 | Transplant Proc1988，20，4： | 1 |
| 10 | Assumption-free analysis of quantitative real-time polymerase chain reac-tion(PCR)data显示文摘 | Ramakers C Ruijter J M Deprez R H | | Neurosci Lett0，339，1： | 1 |
| 11 | Non-radioactive in situ detection of mRNA in ES cell-derived cardiomyocytes and in the developing heart显示文摘 | FIJNVANDRAAT A C DE BOER P A DEPREZ R H | 2002 | Microsc Res Tech2002，58，： | 1 |
| 12 | Pharmacology and ph-armacokinetics of milnaeipran显示文摘 | Panconi E Deprez D | 2002 | Int CIin Psychopha-rmacol2002，17，1： | 1 |
| 13 | Cholestatic syndrome due to preservation injury after liver transplantation显示文摘 | Adler M Deprez C Richaert | 1988 | Transplant Prec1988，20，： | 1 |
| 14 | Severe acute pancreatitis associated with peliosis hepatis in a patient with systemic lupus erythematosus显示文摘 | LANGLET P KARMALI R DEPREZ C | 2001 | Acta Gastroenterol Belg2001，64，3： | 1 |
| 15 | Surgical management of in- tradttctal papillary mucinous tumors of the pancreas: the role of routine frozen section of the surgical margin, intraoperative endo- scopic staged biopsies of the Wirsung duct, and pancreaticogastric anastomosis 显示文摘 | Gigot JF Deprez P Sempoux C | 2001 | Arch Surg2001，136，11： | 1 |
| 16 | Polymeric proanthocyanidins are catabolized by human colonic microflom into low- molecular-weight phenolic acids显示文摘 | DEPREZ S BREZILLON C RABOT S | 2000 | J Nutr2000，130，11： | 1 |
| 17 | Cholestatic syndrome due to preservation injury after liver transpantation显示文摘 | Deprez C Rickaert F | 1988 | Transplant Proc1988，20，4： | 1 |
| 18 | 3D estimation of soft biological tissue deformation from radio-frequency ultrasound volume acquisitions显示文摘 | Deprez JF Brusseau E Sehmitt C | 2010 | Med Image Anal2010，13，1： | 1 |
| 19 | Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data显示文摘 | Ramakers C Ruijter J M Deprez R H | 2003 | Neurosci Lett2003，339，1： | 1 |
| 20 | Sensitivity and accuracy of quantitative real-time polymerase chain reaction using SYBR green I depends on cDNA synthesis conditions 显示文摘 | Lekanne Deprez R H Fijnvandraat A C Ruijter J M | 2002 | Anal Biochem2002，307，1： | 1 |
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