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| 1 | Xanthogranulomatous cholecystitis: What every radiologist should know显示文摘Xanthogranulomatous cholecystitis(XGC) is an uncommon variant of chronic cholecystitis characterized by xanthogranulomatous inflammation of the gallbladder. Intramural accumulation of lipid-laden macrophages and acute and chronic inflammatory cells is the hallmark of the disease. The xanthogranulomatous inflammation of the gallbladder can be very severe and can spill over to the neighbouring structures like liver, bowel and stomach resulting in dense adhesions, perforation, abscess formation, fistulous communication with adjacent bowel. Striking gallbladder wall thickening and dense local adhesions can be easily mistaken for carcinoma of the gallbladder, both intraoperatively as well as on preoperative imaging. Besides, cases of concomitant gallbladder carcinoma complicating XGC have also been reported in literature. So, we have done a review of the imaging features of XGC in order to better understand the entity as well as to increase the diagnostic yield of the disease summarizing the characteristic imaging findings and associations of XGC. Among other findings, presence of intramural hypodense nodules is considered diagnostic of this entity. However, in some cases, an imaging diagnosis of XGC is virtually impossible. Fine needle aspiration cytology might be handy in such patients. A preoperative counselling should include possibility of differential diagnosis of gallbladder cancer in not so characteristic cases. | Vaibhav P Singh S Rajesh Chhagan Bihari Saloni N Desai Sudheer S Pargewar Ankur Arora | 2016 | World Journal of Radiology2016，8，2： | 21 |
| 2 | Epithelial ovarian cancer:An overview显示文摘Ovarian cancer is the second most common gyneco-logical cancer and the leading cause of death in the United States. In this article we review the diagnosis and current management of epithelial ovarian cancer which accounts for over 95 percent of the ovarian malignancies. We will present various theories about the potential origin of ovarian malignancies. We will discuss the genetic anomalies and syndromes that may cause ovarian cancers with emphasis on Breast cancer type 1/2 mutations. The pathology and pathogenesis of ovarian carcinoma will also be presented. Lastly, we provide a comprehensive overview of treatment strategies and staging of ovarian cancer, conclusions and future directions. | Arpita Desai Jingyao Xu Kartik Aysola Yunlong Qin Chika Okoli Ravipati Hariprasad Ugorji Chinemerem Candace Gates Avinash Reddy Omar Danner Geary Franklin Anachebe Ngozi Guilherme Cantuaria Karan Singh William Grizzle Charles Landen Edward E Partridge Valerie Montgomery Rice E Shyam P Reddy Veena N Rao | 2014 | World Journal of Translational Medicine2014，3，1： | 10 |
| 3 | Imaging and radiological interventions in extra-hepatic portal vein obstruction显示文摘Extrahepatic portal vein obstruction(EHPVO) is a primary vascular condition characterized by chronic long standing blockage and cavernous transformation of portal vein with or without additional involvement of intrahepatic branches, splenic or superior mesenteric vein. Patients generally present in childhood with multiple episodes of variceal bleed and EHPVO is the predominant cause of paediatric portal hypertension(PHT) in developing countries. It is a pre-hepatic type of PHT in which liver functions and morphology are preserved till late. Characteristic imaging findings include multiple parabiliary venous collaterals which form to bypass the obstructed portal vein with resultant changes in biliary tree termed portal biliopathy or portal cavernoma cholangiopathy. Ultrasound with Doppler, computed tomography, magnetic resonance cholangiography and magnetic resonance portovenography are non-invasive techniques which can provide a comprehensive analysis of degree and extent of EHPVO, collaterals and bile duct abnormalities. These can also be used to assess in surgical planning as well screening for shunt patency in post-operative patients. The multitude of changes and complications seen in EHPVO can be addressed by various radiological interventional procedures. The myriad of symptoms arising secondary to vascular, biliary, visceral and neurocognitive changes in EHPVO can be managed by various radiological interventions like transjugular intra-hepatic portosystemic shunt, percutaneous transhepatic biliary drainage, partial splenic embolization, balloon occluded retrograde obliteration of portosystemic shunt(PSS) and revision of PSS. | Sudheer S Pargewar Saloni N Desai S Rajesh Vaibhav P Singh Ankur Arora Amar Mukund | 2016 | World Journal of Radiology2016，8，6： | 8 |
| 4 | Spontaneous fungal peritonitis: Micro-organisms, management and mortality in liver cirrhosis-A systematic review显示文摘BACKGROUND Spontaneous peritonitis is an infection of ascitic fluid without a known intraabdominal source of infection. spontaneous fungal peritonitis (SFP) is a potentially fatal complication of decompensated cirrhosis, defined as fungal infection of ascitic fluid in the presence of ascitic neutrophil count of greater than 250 cells/mL. AIM To determine the prevalence of fungal pathogens, management and outcomes (mortality) of SFP in critically ill cirrhotic patients. METHODS Studies were identified using PubMed, EMBASE, Cochrane Central Register of Controlled Trials and Scopus databases until February 2019. Inclusion criteria included intervention trials and observation studies describing the association between SFP and cirrhosis. The primary outcome was in-hospital, 1-mo, and 6- mo mortality rates of SFP in cirrhotic patients. Secondary outcomes were fungal microorganisms identified and in hospital management by anti-fungal medications. The National Heart, Lung and Blood Institute quality assessment tools were used to assess internal validity and risk of bias for each included study. RESULTS Six observational studies were included in this systematic review. The overall quality of included studies was good. A meta-analysis of results could not be performed because of differences in reporting of outcomes and heterogeneity of the included studies. There were 82 patients with SFP described across all the included studies. Candida species, predominantly Candida albicans was the fungal pathogen in majority of the cases (48%-81.8%) followed by Candida krusei (15%- 25%) and Candida glabrata (6.66%-20%). Cryptococcus neoformans (53.3%) was the other major fungal pathogen. Antifungal therapy in SFP patients was utilized in 33.3% to 81.8% cases. The prevalence of in hospital mortality ranged from 33.3% to 100%, whereas 1-mo mortality ranged between 50% to 73.3%. CONCLUSION This systematic review suggests that SFP in end stage liver disease patient is associated with high mortality both in the hospital and at 1-mo, and that antifungal therapy is currently underutilized. | Tooba Tariq Furqan B Irfan Mehdi Farishta Brian Dykstra Eric Martin Sieloff Archita P Desai | 2019 | World Journal of Hepatology2019，11，7： | 7 |
| 5 | Burden of care in caregivers of patients with alcohol use disorder and schizophrenia and its association with anxiety, depression and quality of life显示文摘Background Caregivers play a pivotal role in providing care for mentally ill patients.Increase in caregiver burden can make them vulnerable to mental illness themselves.Aims We assessed the severity of burden of care and its association with depression,anxiety and quality of life among caregivers of patients with alcohol use disorder(AUD)and schizophrenia.Methods This was an observational,cross-sectional,single-centred study of 50 consecutive caregivers of patients with AUD and schizophrenia.Participants were recruited from the psychiatry outpatient department of a tertiary care hospital between January and June 2017.The caregivers were further assessed by demographic details,Hospital Anxiety Depression Scale for assessment of depression and anxiety,Zarit Burden Interview for assessment of caregiver burden and WHO Quality Of Life-BREF for assessment of quality of life.Statistical data were analysed using GraphPad InStat V.3.06(California).Multiple linear regression analysis was applied to identify the predictors of caregiver burden.Results Burden of care experienced by caregivers of patients with AUD is as high as that of caregivers of patients with schizophrenia(U=1142.5,p=0.46).Caregivers experiencing high burden of care are likely to have symptoms of anxiety(U=22,p<0.001),depression(U=32,p<0.001)and poor quality of life(U=84.5,p<0.001).Female caregivers are likely to experience higher burden of care(U=819.5,p=0.006).For caregivers of patients with schizophrenia,anxiety,environmental health,socioeconomic status and patients,occupation can predict burden of care,while for caregivers of patients with AUD,depression and environmental health can predict burden of care.Conclusion Our study suggests that caregivers of patients with AUD experience burden of care as high as that of caregivers of patients with schizophrenia.Caregivers with high burden of care are more likely to have depression,anxiety and poor quality of life.Trial registration number CTRI/2017/03/008224. | Sneha Vadher Rishi Desai Bharat Pancha Ashok Vala Imran Jahangirali Ratnani Mihir P Rupani Kinjal Vasava | 2020 | General Psychiatry2020，33，4： | 7 |
| 6 | Modeling and control of the Mitsubishi PA-10 robot ann harmonic drive system显示文摘 | Kennedy C W Desai J P | 2005 | IEEE/ASME Trans Mechatronies2005，，10： | 1 |
| 7 | The sequence and phylogenetic analysis of a novel hepatitis E virus isolated from a patient with acute hepatitis reported in the United States显示文摘 | Schlauder G G Dawson G J Erker J C Kwo P Y Knigge M F Smalley D L Rosenblatt J E Desai S M Mushahwar I K | 1998 | J Gen Virol1998，79，3： | 1 |
| 8 | Obesity is associated with macrophage accumulation in adipose tissue显示文摘 | MCCANN D DESAI M | 2003 | J Clin Invest2003，112，12： | 1 |
| 9 | Synthesis of some Schiff base thiazolidinones and azetidinones显示文摘 | Desai S B Desai P B Desai K R | 2001 | Hetercycl Commun2001，7，1： | 1 |
| 10 | Modeling and control of formations of nonholonomic mobile robots显示文摘 | Desai J P Ostrowski J P Kumar V | 2001 | IEEE Transactions on Robotics and Automation2001，17，6： | 1 |
| 11 | Nonlinear analysis of 3D seismic interaction of soil-pile-structure systems and application显示文摘 | CAI Y X GOULD P L DESAI C S | 2006 | Engineering Structures2006，28，： | 1 |
| 12 | Carriage of methicillin-resistant staphylococcus aureus is associated with an increased risk of infection after liver transplantation 显示文摘 | Desai D Desai N Nightingale P | 2005 | Liver Transpl2005，9，7： | 1 |
| 13 | Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements显示文摘 | SETCHELL K D R BROWN N M DESAI P | 2001 | J Nutr2001，131，4： | 1 |
| 14 | Carriage of methicillin-resistant Staphylococcus aureus is associated with an increased risk of infection after liver transplantation显示文摘 | Desai D Desai N Nightingale P | 2003 | Liver Transplant2003，9，7： | 1 |
| 15 | Nonlinear analysis of 3D seismic in-teraction of soil-pile-structure systems and application显示文摘 | Cai Y X Gould P L Desai C S | 2000 | Engi-neering Structures2000，22，： | 1 |
| 16 | Pharming and transgenic plants 显示文摘 | Desai P Shrivastava N Padh H | 2007 | Biotechnol Annu Rev2007，13，： | 1 |
| 17 | Hyperthyroidism in Children 显示文摘 | Mokhashi M H Desai U Desai M P | 2000 | Indian J Pediatr2000，67，9： | 1 |
| 18 | Comparison of artificial neural network(ANN ) and response surface methodology (RSM) in fermentation media optimization:Case study of fermentative production of scleroglucaan 显示文摘 | Desai K M Survase S A Saudagar P S | 2008 | Biochemical Engineering Journal2008，41，3： | 1 |
| 19 | Stoichiometric modeling of clostridium acetotutylicum fermentations with non-linear constraints显示文摘 | Desai R P Lars K Nielsen Papoutsakis E T | | 0，，01： | 1 |
| 20 | Quality segmentation in spatial markets: When does cannibalization affect product line design 显示文摘 | Desai P | 2001 | Marketing Science2001，20，3： | 1 |
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