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| 1 | Prognostic criteria for postoperative mortality in 170 patients undergoing major right hepatectomy显示文摘BACKGROUND: Postoperative hepatic failure is a dreadful complication after major hepatectomy and carries high morbidity and mortality rates. In this study, we assessed the accuracy of the 50/50 criteria (bilirubin >2.9 mg/dL and international normalized ratio >1.7 on postoperative day 5) and the Mullen criteria (bilirubin peak >7 mg/dL on postoperative days 1-7) in predicting death from hepatic failure in patients undergoing right hepatectomy only. In addition, we identified prognostic factors linked to intra-hospital morbidity and mortality in these patients. METHODS: One hundred seventy consecutive patients underwent major right hepatectomy at a tertiary medical center from 2000 to 2008. Nineteen (11.2%) patients suffered from liver cirrhosis. Univariate and multivariate analyses were performed to identify predictors of intra-hospital mortality, morbidity and death from hepatic failure. RESULTS: The intra-hospital mortality was 6.5% (11/170). Of the six patients who died from hepatic failure, one was positive for the 50/50 criteria, but all six patients were positive for the Mullen criteria. Multivariate analysis showed that male gender, hepatitis C (HCV), hepatocellular carcinoma, postoperative bilirubin >7 mg/dL and ALT<188 U/L on postoperative day 1 were predictive of death from hepatic failure in the postoperative period. Age >65 years, HCV, reoperation, andrenal failure were significant predictors of overall intra-hospital mortality on multivariate analysis. CONCLUSIONS: The Mullen criteria were more accurate than the 50/50 criteria in predicting death from hepatic failure in patients undergoing right hepatectomy. A bilirubin peak >7 mg/dL in the postoperative period, HCV positivity, hepatocellular carcinoma, and an ALT level <188 U/L on postoperative day 1 were associated with death from hepatic failure in our patient population. | Filippo Filicori Xavier M Keutgen Matteo Zanello Giorgio Ercolani Salomone Di Saverio Federico Sacchetti Antonio Daniele Pinna Gian Luca Grazi | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 2 |
| 2 | Increased activity of the ubiquitin-proteasome system in patients with symptomatic carotid disease is associated with enhanced inflammation and may destabilize the atherosclerotic plaque: effects of rosiglitazone treatment显示文摘 | Marfella R D'Amico M Di Filippo C | 2006 | J Am Coil Cardio2006，47，12： | 1 |
| 3 | The possible role of the ubiquitin proteasome system in the development of atherosclerosis in diabetes显示文摘 | Marfella R D'Amico M Di Filippo C | | 0，，： | 1 |
| 4 | Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa显示文摘 | De Filippo C Cavalieri D Di Paola M | | 0，，： | 1 |
| 5 | Pharmacological res- cue of caruitine transport in primary earnitine deficiency 显示文摘 | Di san Filippo CA Pasquali M Longo N | 2006 | Hum Mutat2006，27，： | 1 |
| 6 | Tight glycemic control reduces heart inflammation and remodeling during acute myocardial infarction in hyperglycemic patients显示文摘 | Marfella R Di Filippo C Portoghese M | 2009 | J Am Coll Cardiol2009，53，16： | 1 |
| 7 | Definitive body height in constitutional retardation of growth and puberty显示文摘 | Salerno M de Filippo G di Maio S | 1996 | Arch Pediatr1996，3，9： | 1 |
| 8 | Myocardial infarctionin diabetic rats: role of hyperglycaemia on infarct size and early ex-pression of hypoxia-inducible factor 1 显示文摘 | Marfella R D'Amico M Di Filippo C | 2002 | Diabetologia2002，45，8： | 1 |
| 9 | Optimization of sodium removal inpcured dialysis by single pool sodium and conductivity kinetic models 显示文摘 | Di Filippo S cort M Audruli S | 1997 | Blood piurif1997，15，： | 1 |
| 10 | The integrated treatment of peritoneal carcinomatosis:a preli minary experience显示文摘 | Caraliere F Di Filippo F Cosimelli M | | 0，，02： | 1 |
| 11 | Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa显示文摘 | De Filippo C Cavalieri D Di Paola M | | 0，，： | 1 |
| 12 | CSF proteome analy- sis in multiple sclerosis patients by two - dimensional electrophoresis 显示文摘 | Chiasserini D Di Filippo M Candeliere A | 2008 | Europ J Neurol2008，15，9： | 1 |
| 13 | Disorders of carnitine transport and the camitine cycle 显示文摘 | Longo N Amat di San Filippo C Pasquali M | 2006 | Am J Med Genet C Semirimed Genet2006，142，： | 1 |
| 14 | Tight glycemic control reduces heart inflammation and remodeling during acute myocardial infarction in hyperglycemic patients显示文摘 | MarfeUa R Di Filippo C Portoghese M | 2009 | JACC2009，53，16： | 1 |
| 15 | Disorders of caruitine transport and the carnitine cycle显示文摘 | Longo N Amat di San Filippo C Pasquali M | 2006 | Am J Med Genet C Semin Med Genet2006，142，2： | 1 |
| 16 | Obstructivesleep apnea syndrome显示文摘 | Mannarino MR Di Filippo F Pirro M | 2012 | Eur J Intern Med2012，23，： | 1 |
| 17 | Pharmacological rescue of carnitine transport in primary carnitine deficiency 显示文摘 | Amat di San Filippo C Pasquali M Longo N | 2006 | Hum Mutat2006，27，： | 1 |
| 18 | Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa显示文摘 | De Filippo C Cavalieri D Di Paola M | 2010 | Proc Natl Acad Sci U S A2010，107，14： | 1 |
| 19 | Myocardial infarction in diabetic rats:role of hyperglycaemia on infarct size and early expressian of hypexia-inducible factor 1显示文摘 | D'Amico M Di Filippo C | 2002 | Diabetolngia2002，45，： | 1 |
| 20 | Proteasome activity as a target of hormonereplacement therapy - dependent plaque stabihzation in postmenopausal women显示文摘 | Marfella R Di Filippo C Portoghese M | 2008 | Hypertension2008，51，4： | 1 |
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