4篇
您的检索式：作者名="DI Zhenghan"
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| 1 | DNA-mediated coordinative assembly of upconversion hetero-nanostructures for targeted dual-modality imaging of cancer cells显示文摘superstructures has enormous potential in material sciences and engineering. Despite the potential,controlled assembly of different kinds of NPs into spatially addressable hybrid configurations still remains a formidable challenge. Herein, we report a simple and universal strategy for DNA-mediated assembly of CdTe quantum dots(QDs) and lanthanide-doped upconversion nanoparticles(UCNPs). Such DNA-QD/UCNPs heterostructures not only maintains both fluorescent properties of QDs and upconversion luminescence behaviors of UCNPs, but also offers a polyvalent DNA surface, allowing for targeted dual-modality imaging of cancer cells using an aptamer. The hetero-assembly mediated by the DNA à inorganic interfacial interaction may provide a scalable way to fabricate hybrid superstructures of both theoretical and practical interests. | Wenting Xue Zhenghan Di Ya Zhao Aiping Zhang Lele Li | 2019 | Chinese Chemical Letters2019，30，4： | 4 |
| 2 | Clinical practice guideline for body composition assessment based on upper abdominal magnetic resonance images annotated using artificial intelligence显示文摘Introduction Upper abdominal magnetic resonance(MR)imaging is appropriate for body composition analysis.111 Especially for individuals with obesity,it is of great value to quantify the hepatic proton density fat fraction(PDFF)and the amount of abdominal adipose tissue during clinical evaluation and for research on obesity-related risks.Analytical results may be used to determine the optimal choice of surgical procedure and evaluate treatment outcomes.Multiple artificial intelligence(Al)algorithms and systems have been developed for the automated measurement of body composition.The basis of Al development and application is to have uniform standards for clinical data acquisition and management.The uneven quality ofMR images is one ofthe major obstacles to Al system development and analytical results.A standardized process of MR scanning and clinical data management is urgently needed. | Han Lv Mengyi Li Zhenchang Wang Dawei Yang Hui Xu Juan Li Yang Liu Di Cao Yawen Liu Xinru Wu He Jin Peng Zhang Liqin Zhao Rixing Bai Yunlong Yue Bin Li Nengwei Zhang Mingzhu Zou Jinghai Song Weibin Yu Pin Zhang Weijun Tang Qiyuan Yao Liheng Liu Hui Yang Zhenghan Yang Zhongtao Zhang National Clinical Research Center for Digestive Diseases in Beijing Friendship Hospital,Capital Medical University Beijing Quality Control and Improvement Center of Medical Imaging National Health Commission Capacity Building and Continuing Education Center,Chinese College of Metabolic and Bariatric Surgeons Beijing Quality Control and Improvement Center of Metabolic and Bariatric Surgery | 2022 | Chinese Medical Journal2022，，6： | 1 |
| 3 | Self-assembly of DNA Nanostructures via Bioinspired Metal Ion Coordination显示文摘Despite a growing interest in DNA nanomaterials,their simple synthesis remains a challenge.A simple and general strategy for constructing DNA-based nanomaterials by metal ion coordination is reported.The me-tal-DNA nanoparticles(NPs)could be synthesized with DNA molecules of diverse sequence and various metal ions of intrinsic property,resulting in multifunctional NPs with the combined advantages of both inorganic and DNA building blocks.It is demonstrated that the hybrid metal-DNA NPs could be engineered for magnetic resonance and luminescence imaging,encapsulation of multifarious nucleic acids with controlled ratio,and co-assembly with small drug molecules.Furthermore,because these metal-DNA NPs exhibited enhanced cellular uptake compared to free synthetic DNA,they hold potential for applications in diagnostics and therapeutics. | WANG Congli DI Zhenghan FAN Zetan LI Lele | 2020 | Chemical Research in Chinese Universities2020，36，2： | 0 |
| 4 | Coordination-driven self-assembly of metallo-nanodrugs for local inflammation alleviation显示文摘Developing dedicated nanomedicines to improve delivery efficacy of anti-inflammatory drugs is still a formidable challenge.In this study,we present an extremely simple yet efficient approach to obtain hybrid nanodrugs through metal-drug coordination-driven self-assembly for carrier-free drug delivery.The resulting metallo-nanodrugs exhibit well-defined morphology and high drug encapsulation capability,allowing for the combination of magnetic resonance imaging and anti-inflammatory therapy.In the case of osteoarthritis(OA),the metallo-nanodrugs remarkably alleviate synovial inflammation,preventing cartilage destruction and extracellular matrix loss.In addition,it led to significantly improved therapeutic efficacy compared with intra-articular administration of the same dose of free drugs in OA mouse model.This work provides a very simple approach for the development of anti-inflammatory nanoformulations by exploiting coordination-driven self-assembly. | Lijuan Tang Zhenghan Di Jingfang Zhang Feiying Yin Lele Li Li Zheng | 2023 | Nano Research2023，16，12： | 0 |
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