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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Evaluation of brain natri-uretic peptide in the diagnosis of heart failure显示文摘 | Bettenc Ourt P Ferreira A Dias P | 2000 | Cardiology2000，93，： | 1 |
| 3 | Hydrophobic, highly conductive ambient-temperature molten salts显示文摘 | Bomhote P Dias A P Papageorgiou N | 1996 | Inorg Chem1996，35，： | 1 |
| 4 | Prdictors of preognosis in patients with stable mild to moderateheartfailure显示文摘 | Bettencourt P Ferreira A Dias P | 2000 | JCard Fail2000，6，： | 1 |
| 5 | Hydrophobic , highly conductive ambient-temperature molten salts 显示文摘 | Dias A P Papageorgiou N | 1996 | Inorg Chem1996，35，5： | 1 |
| 6 | Evaluation of brain natriuretic peptide in the diagnosis of heart failure显示文摘 | Bettencourt P Ferreira A Dias P | 2000 | Cardiology2000，93，： | 1 |
| 7 | Hydrophobic, highly conductive ambient-temperature molten sahs显示文摘 | Bonhote P Dias A P Papageorgiou N | 1996 | Inorganic Chemistry1996，35，5： | 1 |
| 8 | Prognostic factors and out- come for nasopharyngeal carcinoma 显示文摘 | Farias T P Dias F L Lima R A | 2003 | Arch Otolalyngol Head Neek Surg2003，129，7： | 1 |
| 9 | 显示文摘 | Pavan F A Dias S L P Lima E C | 2008 | Dyes Pigments2008，76，： | 1 |
| 10 | Hydrophobic, highly conductive ambient temperature ionic liquids 显示文摘 | BONHOTE P DIAS A P PAPAGEORGIOU N | 1996 | Inorg Chem1996，35，5： | 1 |
| 11 | Results of stereotactic radiosurgery of arteriovenous malformations: an analysis of 52 cases显示文摘 | Kemeny A A Dias P S Forster D M | 1989 | J Neurol Neurosurg Psychiatry1989，52，5： | 1 |
| 12 | Magnesium and its alloys as orthopedic biomaterials: A review显示文摘 | STAIGER M P PIETAK A M HUADMAI J DIAS G | 2006 | Biomaterials2006，27，9： | 1 |
| 13 | Hy- drophobic highly conductive ambient-temperature molten salts显示文摘 | BONHOTE P DIAS A PAPAGEORGIOU N | 1996 | Inorg Chem1996，35，5： | 1 |
| 14 | Hydrophobic,highly conductive ambient-temperature molten salts显示文摘 | Bongote P Dias A P Papageorgiou N | 1996 | Inorg Chem1996，35，5： | 1 |
| 15 | Cytogenetic analysis of spontaneously activated noninseminated oocytes and parthenogene -tically activated failed fertilized human oocytes -implications for the use of primate parthenotes for stem cell production显示文摘 | SANTOS T A DIAS C HENNIQUES P | 2003 | J Assist Reprod Genet2003，20，3： | 1 |
| 16 | Cultivation-independent methods applied to the microbial prospection of oiland gas in soil from a sedimentary basin in Brazil显示文摘 | MIQUELETTO P B ANDREOTE F D DIAS A CF | 2011 | AMB Ex-press2011，1，： | 1 |
| 17 | Evaluation of brain natriuretic peptide in the diagnosis of heart failure显示文摘 | Bettencourt P Ferreira A Dias P | | 0，，1： | 1 |
| 18 | Mechanical properties of hardened cement paste exposed to temperatures up to 700C (1292F)显示文摘 | Dias W P S Khoury G A Sullivan P J E | 1990 | Material Journal1990，87，2： | 1 |
| 19 | Bone-like matrix for- mation on magnesium and magnesium alloys显示文摘 | Pietak A Mahoney P Dias GJ | 2008 | J Mater Sci Mater Med2008，19，1： | 1 |
| 20 | Yellow passion-fruit shell as biosorbent to remove Cr(Ill) and Pb(11) from aqueous solution显示文摘 | Jacques R A Lima E C Dias S L P | 2007 | Separation and Purification2007，57，1： | 1 |
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