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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Mineralogy and geochemistry of hydrothermal sediments from the serpentinite-hosted Saldanha hydrothermal field ( 36°34' N ; 33 ° 26' W) at MAR 显示文摘 | Dias A S Barriga F J | 2006 | Marine Geology2006，225，： | 1 |
| 3 | Efficacy of CFRP- based techniques for the flexural and shear strengthening of concrete beams 显示文摘 | Barros J A O Dias S J E Lima J 1 T | 2007 | Cement and Concrete Composites2007，29，3： | 1 |
| 4 | prediction of selec- tive fetal growth restriction and twin-to-twin transfusion syn- drome in monoehorionic twins 显示文摘 | Memmo A Dias T Mahsud-Dornan S | 2012 | BJOG2012，119，4： | 1 |
| 5 | The effect of stirring and seeding on the AcPheLeuNH2 synthesis and crystallization in a reversed micellar system显示文摘 | FELICIANO A S DIAS A I PRAZERES D M F | 2000 | Enzy & Microb Tech2000，27，： | 1 |
| 6 | Seawater Sr isotope variation over the past 300 kyr and influence of global climate cycles 显示文摘 | Dia A N Cohen A S O'Nions R K | 1992 | Nature1992，356，： | 1 |
| 7 | Prediction of selec- tive fetal growth restriction and twin-to-twin transfusion syndrome in monoehorionic twins 显示文摘 | Memmo A Dias T Mahsud-Dornan S | 2012 | B JOG2012，119，： | 1 |
| 8 | 显示文摘 | Pavan F A Dias S L P Lima E C | 2008 | Dyes Pigments2008，76，： | 1 |
| 9 | Adhesion prevention agents for gynaecological surgery: An overview of Cochrane reviews显示文摘 | HINDOCHA A BEERE L DIAS S | 2015 | Cochrane Database Syst Rev2015，1，01： | 1 |
| 10 | Results of stereotactic radiosurgery of arteriovenous malformations: an analysis of 52 cases显示文摘 | Kemeny A A Dias P S Forster D M | 1989 | J Neurol Neurosurg Psychiatry1989，52，5： | 1 |
| 11 | Characterisation by EIS of ternary Mg alloys synthesized by mechanical alloying显示文摘 | CHRISTOPHER M A BRETT DIAS L TR1NDADE B FISCHER R M1ES S | 2006 | Electrochimica Acta2006，51，： | 1 |
| 12 | Nanosized and re- usable SiO2/ZrO2 catalyst for highly efficient biodiesel production by soybean ktransesterification显示文摘 | Faria E A Marques J S Dias I M | 2009 | Braz Chem Soc2009，20，： | 1 |
| 13 | Immobilization of Fe, Mn and Co tetraphenylporphyrin complexes in MCM-41 and their catalytic activity in cyclohexene oxidation reaction by hydrogen peroxide 显示文摘 | COSTA A A GHESTI G F MACEDO J L BRAGA V S SANTOS M M DIAS J A DIAS S C L | 2008 | J Mol Catal A: Chem2008，282，： | 1 |
| 14 | Dehydration of xylose into furfural over micro-mesoporous sulfonic acid catalysts显示文摘 | Ana S Dias Martyn Pillinger Anabela A Valente | 2005 | Journal of Catalysis2005，229，2： | 1 |
| 15 | Evaluation of the protective effects of quercetin in the hepatopulmonary syndrome显示文摘 | TIEPPO J VERCELINO R DIAS A S | 2007 | Food and Chemical Toxicology2007，45，： | 1 |
| 16 | Modified versions of sulfated zirconia as catalysts for the conversion of xylose to furfural显示文摘 | DIAS A S LIMA S PILLINGER M | 2007 | Catalysis Letters2007，114，34： | 1 |
| 17 | Tuning hole mobility in InP nanowires显示文摘 | REBELLO M DIAS S PICININ A | 2012 | Appl Phys Lett2012，101，18： | 1 |
| 18 | Mechanical properties of hardened cement paste exposed to temperatures up to 700C (1292F)显示文摘 | Dias W P S Khoury G A Sullivan P J E | 1990 | Material Journal1990，87，2： | 1 |
| 19 | New catalogue of optically visible open clusters and candidates显示文摘 | DIAS W S ALESSI B S MOITINHO A | 2002 | A&A2002，389，3： | 1 |
| 20 | Preparation and evaluation of a coumarin librkry towards the inhibitory activity of the enzyme GAPDH from Trypanosoma cruzi 显示文摘 | Joel Alvim Jr Ricardo L A Dias Marcelo S | 2005 | Journal of the Brazilian Chemical Society2005，16，4： | 1 |
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