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| 1 | Viral hepatitis update: Progress and perspectives显示文摘Viral hepatitis,secondary to infection with hepatitis A,B,C,D,and E viruses,are a major public health problem and an important cause of morbidity and mortality.Despite the huge medical advances achieved in recent years,there are still points of conflict concerning the pathogenesis,immune response,development of new and more effective vaccines,therapies,and treatment.This review focuses on the most important research topics that deal with issues that are currently being solved,those that remain to be solved,and future research directions.For hepatitis A virus we will address epidemiology,molecular surveillance,new susceptible populations as well as environmental and food detections.In the case of hepatitis B virus,we will discuss host factors related to disease,diagnosis,therapy,and vaccine improvement.On hepatitis C virus,we will focus on pathogenesis,immune response,direct action antivirals treatment in the context of solid organ transplantation,issues related to hepatocellular carcinoma development,direct action antivirals resistance due to selection of resistanceassociated variants,and vaccination.Regarding hepatitis D virus,we describe diagnostic methodology,pathogenesis,and therapy.Finally,for hepatitis E virus,we will address epidemiology(including new emerging species),diagnosis,clinical aspects,treatment,the development of a vaccine,and environmental surveillance. | María B Pisano Cecilia G Giadans Diego M Flichman Viviana E Ré María V Preciado Pamela Valva | 2021 | World Journal of Gastroenterology2021，27，26： | 8 |
| 2 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 3 | Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation显示文摘Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, how ever, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement. One active ingredient in this supplement is hydroxycitric acid, an active ingredient also found in weight-loss supplements banned by the Food and Drug Administration in 2009 for hepatotoxicity. Heightened awareness of the dangers of dietary supplements such as Garcinia cambogia is imperative to prevent hepatoxicity and potential fulminant hepatic failure in additional patients. | Keri E Lunsford Adam S Bodzin Diego C Reino Hanlin L Wang Ronald W Busuttil | 2016 | World Journal of Gastroenterology2016，22，45： | 3 |
| 4 | Global, regional, and national causes of child mortality in 2008: a systematic analysis显示文摘 | Robert E Black Simon Cousens Hope L Johnson Joy E Lawn Igor Rudan Diego G Bassani Prabhat Jha Harry Campbell Christa Fischer Walker Richard Cibulskis Thomas Eisele Li Liu Colin Mathers | 2010 | The Lancet2010，，9730： | 3 |
| 5 | Global, regional, and national causes of child mortality in 2008: a systematic analysis显示文摘 | Robert E Black Simon Cousens Hope L Johnson Joy E Lawn Igor Rudan Diego G Bassani Prabhat Jha Harry Campbell Christa Fischer Walker Richard Cibulskis Thomas Eisele Li Liu Colin Mathers | 2010 | The Lancet . 2010 (9730)2010，，： | 2 |
| 6 | Airway inflammation and cough sensitivity in cough variant asthma 显示文摘 | De Diego A Martinez E Perpina M | 2005 | Allergy2005，60，11： | 1 |
| 7 | The non-structural polyprotein 3ABC of foot-and mouth disease virus as a diagnostic antigen in ELISA to differentiate infected from vaccinated cattle显示文摘 | Diego M D Brocchi E Mackay D | 1997 | Arch Virol1997，142，： | 1 |
| 8 | The non-structural polyprotein 3ABC of foot-and-mouth disease virus as a diagnostic antigen in ELISA to differentiate infected from vaccinated cattle显示文摘 | DE DIEGO M BROCCHI E MACK AY D | 1997 | Arch Virol1997，142，10： | 1 |
| 9 | Airway inflammation and cough sensitivity in cough-variant asthma显示文摘 | De Diego A Martinez E Perpina M | 2005 | Allergy2005，，60： | 1 |
| 10 | Effects of long-term azithromycin therapy on airway oxidativestress markers in non-cystic fibrosis bronchitctasis 显示文摘 | DIEGO A D MILARA J MARTINEZ-MORAG6N E | 2013 | Respirology2013，18，7： | 1 |
| 11 | Effects of marine microbial biofilms on the biocide release rate from antifouling paints- A model-based analysis显示文摘 | Diego M Y Soren K Claus E | 2006 | Prog Org Coat2006，57，： | 1 |
| 12 | Airway inflammation and cough sensitivity in cough - variant asthma 显示文摘 | De Diego A Martinez E Perpina M | 2005 | Allergy2005，60，11： | 1 |
| 13 | Airway inflammation and cough sensitivity in cough-variant asthma显示文摘 | De Diego A Martinez E Perpis M | 2005 | Allergy2005，60，： | 1 |
| 14 | CXCR4 and CCR5 expression by H9 T-cells ids downregulated by a peptide-nucleic acid immunomodulator显示文摘 | Lazzarino DA Diego M Musi E | 2000 | Immunol Lett2000，74，： | 1 |
| 15 | The nonstrucrural protein 3ABC of foot-and-mouth disease virus as a diagnostic antigen in ELISA to differentiate infected from vaccinated cattle显示文摘 | De Diego M Brocchi E Mackay D | 1997 | Arch Virol1997，142，10： | 1 |
| 16 | High-performance capillary electrophoretic method for the quantification of 5-methyl 2′-deoxycytidine in genomic DNA:Application to plant,animal and human cancer tissues显示文摘 | Fraga M F Uriol E Borja Diego L | 2002 | Electrophoresis2002，23，11： | 1 |
| 17 | Bi-lateral multiple renal oncocytoma : case report and review of thelilerature显示文摘 | Villanueva A Roca Edreira A de Diego Rodriguez E | 2007 | Prog Urol2007，17，5： | 1 |
| 18 | Geospatial video monitoring of nearshore benthic habitats of western Biscayne Bay (Florida) using the shallow-water positioning system (SWaPS)显示文摘 | Diego L Gregory D Joseph E S | | 0，，1： | 1 |
| 19 | THE nonstructural polyprotein 3ABC of foot-and-mouth disease virus as a diagnostic antigen in ELISA to differentiate infected from vaccinated cattle显示文摘 | M De Diego A E Brocchi A D Mackay A | 1997 | Archives of Virology1997，142，10： | 1 |
| 20 | Modelling mass transfer in the PCA process using the Maxwell Stefan approach 显示文摘 | DE DIEGO Y P WUBBOLTS F E JANSENS P J | 2006 | The Journal of Supereritieal Fluids2006，37，1： | 1 |
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