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| 1 | Adiponectin,a key adipokine in obesity related liver diseases显示文摘Non-alcoholic fatty liver disease (NAFLD) comprising hepatic steatosis,non-alcoholic steatohepatitis (NASH),and progressive liver fibrosis is considered the most common liver disease in western countries.Fatty liver is more prevalent in overweight than normal-weight people and liver fat positively correlates with hepatic insulin resistance.Hepatic steatosis is regarded as a benign stage of NAFLD but may progress to NASH in a subgroup of patients.Besides liver biopsy no diagnostic tools to identify patients with NASH are available,and no effective treatment has been established.Visceral obesity is a main risk factor for NAFLD and inappropriate storage of triglycerides in adipocytes and higher concentrations of free fatty acids may add to increased hepatic lipid storage,insulin resistance,and progressive liver damage.Most of the adipose tissue-derived proteins are elevated in obesity and may contribute to systemic inflammation and liver damage.Adiponectin is highly abundant in human serum but its levels are reduced in obesity and are even lower in patients with hepatic steatosis or NASH.Adiponectin antagonizes excess lipid storage in the liver and protects from inflammation and fibrosis.This review aims to give a short survey on NAFLD and the hepatoprotective effects of adiponectin. | Christa Buechler Josef Wanninger Markus Neumeier | 2011 | World Journal of Gastroenterology2011，17，23： | 44 |
| 2 | Multipurpose use of the over-the-scope-clip system(“Bear claw”) in the gastrointestinal tract:Swiss experience in a tertiary center显示文摘AIM:To evaluate the outcome of over-the-scope-clip system(OTSC)for endoscopic treatment of various indications in daily clinical practice in Switzerland.METHODS:This prospective,consecutive case series was conducted at a tertiary care hospital from September 2010 to January 2014.Indications for OTSC application were fistulae,anastomotic leakage,perforation,unroofed submucosal lesion for biopsy,refractory bleeding,and stent fixation in the gastrointestinal(GI)tract.Primary technical success was defined as the adequate deployment of the OTSC on the target lesion.Clinical success was defined as resolution of the problem;for instance,no requirement for surgery or further endoscopic intervention.In cases of recurrence,retreatment of a lesion with a second intervention was possible.Complications were classified into those related to sedation,endoscopy,or deployment of the clip.RESULTS:A total of 28 OTSC system applications werecarried out in 21 patients[median age 64 years(range42-85),33%females].The main indications were fistulae(52%),mostly after percutaneous endoscopic gastrostomy tube removal,and anastomotic leakage after GI surgery(29%).Further indications were unroofed submucosal lesions after biopsy,upper gastrointestinal bleeding,or esophageal stent fixation.The OTSC treatments were applied either in the upper(48%)or lower(52%)GI tract.The mean lesion size was 8 mm(range:2-20 mm).Primary technical success and clinical success rates were 85%and 67%,respectively.In53%of cases,the suction method was used without accessories(e.g.,twin grasper or tissue anchor).No endoscopy-related or OTSC-related complications were observed.CONCLUSION:OTSC is a useful tool for endoscopic closure of various GI lesions,including fistulae and leakages.Future randomized prospective multicenter trials are warranted. | Michael Christian Sulz Reto Bertolini Remus Frei Gian-Marco Semadeni Jan Borovicka Christa Meyenberger | 2014 | World Journal of Gastroenterology2014，20，43： | 17 |
| 3 | 单次不安运动质量评估对高危儿运动发育的预测价值显示文摘【Objective】 To study the predictive value of a single qualitive assessment of general movements(GMs) in fidgety period(fidgety movements) for high risk infants’ abnormal motor developmental outcome. 【Methods】 183 high risk infants were accepted a single or multiple GMs assessment in fidgety movements period.Motor developmental outcome was defined by clinical diagnosis and Peabody Motor Develoment Scale assessment after 12-month-age(corrected age of premature infants).The predictive validities were compared between the single assessment group and the multiple assessment group. 【Results】 In the single assessment group,the predictive validity of cerebral palsy was as follows: sensitivity 100%,specificity 93.8%,positive predictive value 87.8%,and negative predictive value 100%;while the predictive validity of abormal motor developmental outcome(cerebral palsy and motor retardation) was as follows: sensitivity 74.0%,specificity 93.9%,positive predictive value 90.2%,and negative predictive value 82.7%.In the multiple assessment group,the predictive validity of cerebral palsy was as follows: sensitivity 85.0%,specificity 89.4%,positive predictive value 77.3%,and negative predictive value 93.3%;while the predictive validity of abormal motor developmental outcome was as follows: sensitivity 77.8%,specificity 97.5%,positive predictive value 95.5%,and negative predictive value 86.7%. 【Conclusions】 The study found a high relationship between a single fidgety movements assessment and the infants’ motor developmental outcome(especially cerebral palsy).Further studies need to be done in general population. | 侯方华 杨红 王艺 史惟 邵肖梅 王卫平 Christa Einspieler 曹云 | 2010 | 中国儿童保健杂志2010，18，11： | 12 |
| 4 | 全身运动评估和听觉诱发电位在脑瘫儿童预测中的意义显示文摘【目的】研究全身运动质量评估(general movements assessment,GMs)及脑干听觉诱发电位(brainstemauditory evoked potential,BAEP)在脑瘫预测中的运用价值。【方法】按照纳入和排除标准选择在本院新生儿重症监护室住院,出院后在新生儿科和康复中心进行随访的高危新生儿为研究对象。每例记录GMs,并行BAEP检查,根据2005年发布的国际脑瘫诊断定义至少在1周岁以上时在临床上进行脑瘫的诊断,作为严重异常的神经学发育结局。统计分析各方法对脑瘫的阳性预测值和阴性预测值、特异性和敏感性。【结果】共随访27名高危新生儿,其中8例运动结局为脑瘫。GMs预测脑瘫敏感度87.5%,特异度84.2%,阳性预测值70.0%,阴性预测值94.1%;BAEP预测脑瘫敏感度75.0%,特异度36.8%,阳性预测值33.3%,阴性预测值77.7%,BAEP异常主要表现为听阈增高及潜伏期延长。【结论】GMs对后期神经发育结局能作出准确有效的预测,尤其对于脑瘫的预测价值相当高,综合运用GMs、BAEP能较全面反应患儿功能状况。 | 龚春丹 杨红 史惟 王艺 邵肖梅 Christa Einspieler 王卫平 | 2011 | 中国儿童保健杂志2011，19，5： | 10 |
| 5 | Are heat stroke and physical exhaustion underestimated causes of acute hepatic failure?显示文摘While cardiopulmonary symptoms are common in patients undergoing classical or, due to physical exercise, exertional heat stroke, the failure of other organs is a rarely described phenomenon. Here we present two cases of acute hepatic failure, one due to classic heat shock, while the other occurred while the patient was doing a marathon-type running. Both cases presented with very high transaminases and significantly elevated international normalized ratio (INR). No other causes for liver failure could be identified but physical exhaustion and hyperthermia. | Kilian Weigand Carina Riediger Wolfgang Stremmel Christa Flechtenmacher Jens Encke | 2007 | World Journal of Gastroenterology2007，13，2： | 8 |
| 6 | 全身运动质量评估:早期预测脑性瘫痪等严重神经学发育结局的实用工具显示文摘 | Christa Einspieler 王艺 Vincent A.O.da Silva 邵肖梅 | 2007 | 中国循证儿科杂志2007，2，3： | 7 |
| 7 | 老年人尿失禁的流行病学和病因学显示文摘尿失禁是老年人的一个普遍问题。22%~34%的妇女声称患过尿失禁。其患病率随尿失禁程度和询问方式不同而变化很大。65岁以上妇女按尿失禁保守定义即常见的尿失禁或按限制定义即压迫性尿失禁,其患病率为10%~30%。这一患病率在长期疗养院内还要高且随被检人群的年龄上升而增高。男性发病率为25%或低于妇女。 | Edward J.McGuire Martin Resnick S.V.Yalla Ruth Kirschner-Hermanns Enrique Broseta Cath McGrother Christa Müller Annette Welz-Barth G.Ch.Fischer Johann Mattelaer 李小刚 | 1999 | 德国医学1999，16，6： | 4 |
| 8 | Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis显示文摘AIM: To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level. METHODS: Fat fed rats were used as a model for fatty liver disease and bile duct ligation in mice to investigate cirrhotic liver. Expression of AdipoR1 and AdipoR2 mRNA was determined by real time RT-PCR. AdipoR1 protein was analysed by immunoblot. Adiponectin was measured by ELISA. RESULTS: Systemic adiponectin is reduced in fat- fed rats but is elevated in mice after bile duct ligation (BDL). Hepatic adiponectin protein is lower in steatotic liver but not in the liver of BDL-mice when compared to controls. Adiponectin mRNA was not detected in human liver samples or primary human hepatocytes nor in rat liver but recombinant adiponectin is taken up by isolated hepatocytes in-vitro. AdipoR1 mRNA and AdipoR1 protein levels are similar in the liver tissue of control and fat fed animals whereas AdipoR2 mRNA is induced. AdipoR2 mRNA and AdipoR1 mRNA and protein is suppressed in the liver of BDL-mice. CONCLUSION: Our studies show reduced circulating adiponectin in a rat model of fatty liver disease whereas circulating adiponectin is elevated in a mouse model of cirrhosis and similar fi ndings have been described in humans. Diminished hepatic expression of adiponectinreceptors was only found in liver cirrhosis. | Markus Neumeier Claus Hellerbrand Erwin Gbele Roland Buettner Cornelius Bollheimer Johanna Weigert Andreas Schffler Thomas S Weiss Monika Lichtenauer Jürgen Schlmerich Christa Buechler | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 9 | First report of colonoscopic closure of a gastrocolocutaneous PEG migration with over-the-scope-clip-system显示文摘Percutaneous endoscopic gastrostomy(PEG) is a common practice for long-term nutrition of patients who are unable to take oral food. We report of an 85-year old man with a history of recurrent larynx carcinoma and hemicolectomy many years ago due to unknown reason. Laryngectomy was indicated. Preoperatively a PEG was inserted endoscopically after an abdominal ultrasonography without abnormal findings. Few months after PEG insertion, the patient was evaluated for diarrhea and insufficient feeding without signs of infection or peritonism. An upper endoscopy and computed tomography scan confirmed a buried bumper syndrome with migration of the PEG tube into the colon as a rare complication. He underwent successful colonoscopic removal of the internal bumper and closure of the colonic orifice of the fistula with the over-the-scope-clip system(OTSC). OTSC is an endoscopic device for treatment of bleeding, perforation, leak and fistula in the gastrointestinal tract. To the best of our knowledge, this is the first report of the use of OTSC for colonoscopic closure of a gastrocolocutaneous fistula due to a buried bumper syndrome with transcolonic PEG tube migration. | Reto Bertolini Christa Meyenberger Michael Christian Sulz | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 10 | Ruptured angiosarcoma of the liver treated by emergency catheter-directed embolization显示文摘血管肉瘤是有差的预后的肝的一个稀罕的主要的恶意的瘤。这里,我们与被紧急情况对待的一个破裂的肝的血管肉瘤报导一个病人的一个案例指导导管的 embolization,由左边的偏身出汗列在后面。 | Christine Leowardi Yura Hormann UIf Hinz Moritz N Wente Peter Hallscheidt Christa Flechtenmacher Markus W Büchler Helmut Friess Matthias HM Schwarzbach | 2006 | World Journal of Gastroenterology2006，12，5： | 4 |
| 11 | Adipose tissue fibrosis显示文摘The increasing prevalence of obesity causes a major interest in white adipose tissue biology.Adipose tissue cells are surrounded by extracellular matrix proteins whose composition and remodeling is of crucial importance for cell function.The expansion of adipose tissue in obesity is linked to an inappropriate supply with oxygen and hypoxia development.Subsequent activation of hypoxia inducible factor 1(HIF-1) inhibits preadipocyte differentiation and initiates adipose tissue fibrosis.Thereby adipose tissue growth is limited and excess triglycerides are stored in ectopic tissues.Stressed adipocytes andhypoxia contribute to immune cell immigration and activation which further aggravates adipose tissue fibrosis.There is substantial evidence that adipose tissue fibrosis is linked to metabolic dysfunction,both in rodent models and in the clinical setting.Peroxisome proliferator activated receptor gamma agonists and adiponectin both reduce adipose tissue fibrosis,inflammation and insulin resistance.Current knowledge suggests that antifibrotic drugs,increasing adipose tissue oxygen supply or HIF-1 antagonists will improve adipose tissue function and thereby ameliorate metabolic diseases. | Christa Buechler Sabrina Krautbauer Kristina Eisinger | 2015 | World Journal of Diabetes2015，6，4： | 3 |
| 12 | Global, regional, and national causes of child mortality in 2008: a systematic analysis显示文摘 | Robert E Black Simon Cousens Hope L Johnson Joy E Lawn Igor Rudan Diego G Bassani Prabhat Jha Harry Campbell Christa Fischer Walker Richard Cibulskis Thomas Eisele Li Liu Colin Mathers | 2010 | The Lancet2010，，9730： | 3 |
| 13 | Endoscopic dilation of complete oesophageal obstructionswith a combined antegrade-retrograde rendezvoustechnique显示文摘AIM: To investigate the combined antegraderetrograde endoscopic rendezvous technique for complete oesophageal obstruction and the swallowing outcome.METHODS: This single-centre case series includes consecutive patients who were unable to swallow due to complete oesophageal obstruction and underwent combined antegrade-retrograde endoscopic dilation(CARD) within the last 10 years. The patients' demographic characteristics, clinical parameters, endoscopic therapy, adverse events, and outcomes were obtained retrospectively. Technical success was defined as effective restoration of oesophageal patency. Swallowing success was defined as either percutaneous endoscopic gastrostomy(PEG)-tube independency and/or relevant improvement of oral food intake, as assessed by the functional oral intake scale(FOIS)(≥ level 3).RESULTS: The cohort consisted of six patients [five males; mean age 71 years(range, 54-74)]. All but one patient had undergone radiotherapy for head and neck or oesophageal cancer. Technical success was achieved in five out of six patients. After discharge, repeated dilations were performed in all five patients. During follow-up(median 27 mo, range, 2-115), three patients remained PEG-tube dependent. Three of four patients achieved relevant improvement of swallowing(two patients: FOIS 6, one patient: FOIS 7). One patient developed mediastinal emphysema following CARD, without a need for surgery.CONCLUSION: The CARD technique is safe and a viable alternative to high-risk blind antegrade dilation in patients with complete proximal oesophageal obstruction. Although only half of the patients remained PEG-tube independent, the majority improved their ability to swallow. | Reto Bertolini Christa Meyenberger Paul Martin Putora Franziska Albrecht Martina Anja Broglie Sandro J Stoeckli Michael Christian Sulz | 2016 | World Journal of Gastroenterology2016，22，7： | 3 |
| 14 | The β-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke显示文摘 | Christa Th?ne-Reineke Christian Neumann Pawel Namsolleck Kristin Schmerbach Maxim Krikov Jan H Schefe Kristin Lucht Heide H?rtnagl Michael Godes Susanne Müller Kay Rumschüssel Heiko Funke-Kaiser Arno Villringer U Muscha Steckelings Thomas Unger | 2008 | Journal of Hypertension2008，，12： | 2 |
| 15 | 【原创论文】德国东西部睾丸癌后发生第二原发癌的风险关注对侧睾丸癌显示文摘上世纪70年代起以顺铂为基础的化疗使睾丸癌的存活率显著提高。然而,化疗和放疗具有潜在的致癌性。本研究的目的是评估德国睾丸癌存活者患第二原发癌(包括原发组织学类型精原细胞瘤和非精原细胞瘤)的风险。我们确认了德国东部地区(1961-1989年和1996-2008年)癌症登记的16990例睾丸癌和德国西部地区萨尔州(1970.2008年)癌症登记的1401例睾丸癌。我们用标准化发病率(SIRs)和95%N信区间(95%CI)估计第二原发癌的风险。我们将估计的年标准化发病率绘制成图以显示趋势。德国东部1961.1989年观察到301例第二原发癌(SIR:1.9;95%CI:1.7-2.1),1996—2008年观察到159例第二原发癌(SIR:1.7:95%CI:1.4~2.0)。两地癌症登记的对侧睾丸癌增加(SIR:萨尔6.0,德国东部13.9)。与其它地区相比,德国东部精原细胞瘤的SIR增加更为显著。数据分析显示对侧睾丸癌的SIR有稳定的趋势。大多数其它癌症(包括组织学特异性肿瘤)的SIRs的估计精度低,可能与样本量较小有关。睾丸癌患者患第二原发癌尤其是对侧睾丸癌的风险增加,因此应进行严密随访。 | Carsten Rusner Brigitte Streller Christa Stegmaier Pietro Trocchi Oliver Kuss Katherine A McGlynn Britton Traberts Andreas Stang | 2014 | Asian Journal of Andrology2014，16，2： | 2 |
| 16 | MULTICENTER STUDY OF EARLY LACTATE CLEARANCE AS A DETERMINANT OF SURVIVAL IN PATIENTS WITH PRESUMED SEPSIS显示文摘 | Ryan C. Arnold Nathan I. Shapiro Alan E. Jones Christa Schorr Jennifer Pope Elisabeth Casner Joseph E. Parrillo R. Phillip Dellinger Stephen Trzeciak | 2009 | Shock2009，，1： | 2 |
| 17 | Global, regional, and national causes of child mortality in 2008: a systematic analysis显示文摘 | Robert E Black Simon Cousens Hope L Johnson Joy E Lawn Igor Rudan Diego G Bassani Prabhat Jha Harry Campbell Christa Fischer Walker Richard Cibulskis Thomas Eisele Li Liu Colin Mathers | 2010 | The Lancet . 2010 (9730)2010，，： | 2 |
| 18 | The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis显示文摘 | Mitchell M. Levy R. Phillip Dellinger Sean R. Townsend Walter T. Linde-Zwirble John C. Marshall Julian Bion Christa Schorr Antonio Artigas Graham Ramsay Richard Beale Margaret M. Parker Herwig Gerlach Konrad Reinhart Eliezer Silva Maurene Harvey Susan Reg | 2010 | Intensive Care Medicine2010，，2： | 2 |
| 19 | Effectiveness of seatbelts in mitigating traumatic brain injury severity显示文摘INTRODUCTION Over the past few decades,traumatic brain injuries(TBIs)have become one of the leading causes of death and the leading cause of injury-related death in the USA.[1,2]It is estimated that 1.70 million people are subject to TBIs each year.[2]Males are more likely to sustain TBIs(59%);the most common age groups are 0–5 years,15–19 years,and>65 years.[2]Approximately 1.36 million people present to the emergency department(ED),275,000 are admitted to the hospital,and 52,000 people die from TBIs.[2]The leading causes of TBIs are falling(35.2%),motor vehicle collisions(MVCs,17.3%),struck by/against an object(16.5%),and assault(10.0%).[2]These statistics combine to make TBIs the leading cause of injury-related death in the USA at 30.5%.[2]It has been estimated that,with specifi c guidelines from the Brain Trauma Foundation,up to 50.0%of the 52,000 TBIrelated deaths may be prevented.[3] | Latha Ganti Aakash NBodhit Yasamin Daneshvar Kelsey Hatchitt Sudeep Kuchibhotla Christa Pulvino Sarah WAyala Keith RPeters | 2021 | World Journal of Emergency Medicine2021，12，1： | 2 |
| 20 | Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography–mass spectrometry显示文摘 | Michel Y Haller Stephan R Müller Christa S McArdell Alfredo C Alder Marc J.-F Suter | 2002 | Journal of Chromatography A2002，，1： | 2 |
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