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| 1 | 唾液腺恶性肿瘤患者的处理及结果显示文摘先进的影像学技术、外束照射、中子束治疗及化疗已改变了人们对唾液腺恶性肿瘤患者的治疗策略。虽然对此类患者目前仍首选外科手术,但对最佳治疗方案仍未达成共识。该文介绍了作者应用手术、放疗、化疗治疗唾液腺恶性肿瘤的经验,并对治疗效果进行回顾,以期找到一个判断患者生存率及原发灶局部控制率的预后指标。对1992—2002年间在其医学院接受治疗的85例唾液腺恶性肿瘤患者行回顾性研究,对数据资料应用描述性统计法进行分析, | Bell RB Dierks E J Homer L | 2005 | 中国口腔颌面外科杂志2005，3，3： | 10 |
| 2 | Innovative immunohistochemistry identifies MMP-9 expressing macrophages at the invasive front of murine HCC显示文摘AIM:To investigate the proteolytic contribution of tumor-associated macrophages(TAM)in tumor invasion,we analyzed whether TAM at the invasive front of small HCC in Abcb4-/--mice show an enhanced expression of MMP-9. METHODS:Liver cryosections of the hepatocellular carcinoma(HCC)invasive front from 12 mo old Abcb4-/--mice were stained for collagen typeⅠand MMP-9 using Alexa488 and Alexa568 labeled secondary antibodies.Afterwards,the Alexa568 dye was bleached and the macrophage marker F4/80 was visualized using Alexa568 labeled secondary antibodies.Finally, photographs of the invasive tumor front were digitally overlaid and analyzed. RESULTS:After complete bleaching of the primary dye,specific fluorescence staining of a third antigen, here F4/80,was successfully performed on the same histological section.With this method,we were able to identify conglomerates of matrix metalloproteinase (MMP-9)expressing macrophages within the tumor capsule of HCC. CONCLUSION:MMP-9 expressing macrophages are involved in matrix remodelling at the invasive tumor front of HCC.The described staining protocol provides a simple yet powerful extension of conventional immuno-histochemistry,facilitating visualization of at least three different antigens plus nuclei in one single histological section. | Martin Roderfeld Timo Rath Frank Lammert Christian Dierkes Jürgen Graf Elke Roeb | 2010 | World Journal of Hepatology2010，2，5： | 6 |
| 3 | Segregation-assisted spinodal and transient spinodal phase separation at grain boundaries显示文摘Segregation to grain boundaries affects their cohesion,corrosion,and embrittlement and plays a critical role in heterogeneous nucleation.In order to quantitatively study segregation and low-dimensional phase separation at grain boundaries,here,we apply a density-based phase-field model.The current model describes the grain-boundary thermodynamic properties based on available bulk thermodynamic data,while the grain-boundary-density profile is obtained using atomistic simulations.To benchmark the performance of the model,Mn grain-boundary segregation in the Fe–Mn system is studied.3D simulation results are compared against atom probe tomography measurements conducted for three alloy compositions.We show that a continuous increase in the alloy composition results in a discontinuous jump in the segregation isotherm.The jump corresponds to a spinodal phase separation at grain boundary.For alloy compositions above the jump,we reveal an interfacial transient spinodal phase separation.The transient spinodal phenomenon opens opportunities for knowledge-based microstructure design through the chemical manipulation of grain boundaries.The proposed density-based model provides a powerful tool to study thermodynamics and kinetics of segregation and phase changes at grain boundaries. | Reza Darvishi Kamachali Alisson Kwiatkowski da Silva Eunan McEniry Dirk Ponge Baptiste Gault Jörg Neugebauer Dierk Raabe | 2020 | npj Computational Materials2020，，1： | 2 |
| 4 | 显示文摘 | Ambrosch A Dierkes J Lobmann R | 2001 | Diabet Med2001，18，3： | 1 |
| 5 | Platelet expression of CD40/CD40 ligand and its relation to inflammatory markers and adhesion molecules in patients with artrial fibrillation显示文摘 | Hammuohner M Jttenson A Dierkes J | | 0，，04： | 1 |
| 6 | Ultrastructural organization and micromechanical properties of shark tooth enameloid显示文摘 | Joachim E Anna M J Dierk R | 2014 | Acta Biomaterialia2014，10，9： | 1 |
| 7 | LeFort I orbitotomy:a new approach to the inferonasal orbital apex显示文摘 | Dailey RA Dierks E Wilkins J | 1998 | Ophthal Plast Reconstr Surg1998，14，1： | 1 |
| 8 | Management of laryngeal trauma显示文摘 | Bell R B Versehueren D S Dierks E J | 2008 | Oral Maxillofac Surg Clin North Am2008，20，3： | 1 |
| 9 | Hyperhomocysteinemia and endothelial dysfuction in IDDM显示文摘 | Ambrosch A Dierkes J Lobmann R | 2001 | Diabetes Med2001，18，3： | 1 |
| 10 | Hyperhomocysteinemia and endothelial dysfunction in IDDM显示文摘 | Ambrosch A Dierkes J Lobmann R | 2001 | Diabet Med2001，18，： | 1 |
| 11 | Water jet discotomy with microinvasive approach-in vitro testing and initial clinical aspects of a new procedure显示文摘 | Honl M Dierk O Kuster J R | 2001 | Z ortho Ihregrenzgeb2001，139，1： | 1 |
| 12 | 显示文摘 | Ambrosch A Dierkes J Lobmann R | 2001 | Diabet Med2001，18，3： | 1 |
| 13 | The nasolabial flap显示文摘 | Brian L Schmidt Eric J Dierks | 2003 | Oral and Maxillofacial Surgery Clinics of North America2003，15，4： | 1 |
| 14 | Detection of cigua-toxin in fish tissue using sandwich ELISA and neuroblastoma cell bioas-say显示文摘 | CAMPORA C E DIERKING J TAMARU C S | 2008 | Journal of Clinical Laboratory Analysis2008，22，： | 1 |
| 15 | 查看详情显示文摘 | Sutanto P Picchioni F Janssen L P B M Dijkhuis K A J Dierkes W K Noordermeer J W M | | 0，，6： | 1 |
| 16 | Relation between homocystein- aemia and diabetes neuropathy in patients with Type 2 diabetic mellitus 显示文摘 | Ambrosch A Dierkes J Lobmann R | 2001 | Diabet Med2001，18，3： | 1 |
| 17 | The number of lymph node metastases in gastric cancer correlates with the angiotensin I-converting enzyme gene insertion/deletion polymorphism 显示文摘 | Rocken C Lendeckel U Dierkes J | 2005 | Clin Cancer Res2005，11，7： | 1 |
| 18 | LeFort I orbitotomy: a new approach to the inferonasal orbital apex 显示文摘 | Dailey RA Dierks E Wilkins J | 1998 | Ophthal Plast Reconstr Surg1998，14，1： | 1 |
| 19 | Battery-induc- tor parametric system analysis for electromagnetic guns 显示文摘 | Dierks E McNab I R Mallick J A | 2011 | IEEE Transactions on Plasma Science2011，39，1： | 1 |
| 20 | Management of cerebrospinal fluid leak associated with craniomaxillofacial trauma显示文摘 | BELL R B DIERKS E J HOMER L | 2004 | J Oral Maxillofac Surg2004，62，6： | 1 |
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