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| 1 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 2 | Monodispete FePt nanoparticles and ferromagnetic FePt nanocrys- tal superlattices 显示文摘 | Sun Shouheng Murray C B Dieter Weller | 2000 | Science2000，287，19： | 1 |
| 3 | Tissue-specific accumulation of metanothionein in chickens as influenced by the route of zinc administration显示文摘 | Fleet J C Qureshi M A Dieter R R | 1988 | J Nutr1988，118，： | 1 |
| 4 | Monodisperse FePt nanoparticles and ferromagnetic FePt nanocrystal super- lattices 显示文摘 | SUN S H MURRAY C B DIETER W | 2000 | Science2000，287，5460： | 1 |
| 5 | Integrating Genomies Into Undergraduate Nursing Education显示文摘 | Daack-Hirsch S Dieter C Quinn Griffin M T | 2011 | J Nurs Scholarsh2011，43，3： | 1 |
| 6 | Reconstructing dry and wet summers in SE Slovenia from oak tree-ring series显示文摘 | KATARINA C MARTIN D L DIETER E | 2008 | International Journal of Biometeorology2008，52，： | 1 |
| 7 | Tissue-specific accumulation of metallothionein in chickens as influenced by the route of zinc administration显示文摘 | Fleet J C Qureshi M A Dieter R R | 1988 | J Nutr1988，118，： | 1 |
| 8 | The Carcinogenic Activity of Commercial Grade Toluene Diisocyanate in Rats and Mice in Relation to the Metabolism of the 2,4-and 2,6-TDI Isomers显示文摘 | DIETER M P BOORMAN G A JAMESON C W | 1990 | Toxicol Indus Health1990，6，6： | 1 |
| 9 | Water turbidity in tilled and untilled prairie wetlands显示文摘 | DIETER C D | 1991 | Journal of Freshwater Ecology1991，6，2： | 1 |
| 10 | Analysis air pollutant taxation:an empirical survey显示文摘 | DIETER C RAIMUND K | 1997 | Ecological Economics1997，，23： | 1 |
| 11 | Monodis -perse FePt nanoparticles and ferromagnetic FePt nanocrystal superlattices 显示文摘 | Sun S Murray C B Dieter W | 2000 | Science2000，287，5460： | 1 |
| 12 | Comparative expression of hedonic impact: affective reactions to taste by human infants and other primates显示文摘 | Jacob E Steiner Dieter Glaser Maria E Hawilo Kent C Berridge | 2001 | Neuroscience and Biobehavioral Reviews2001，，1： | 1 |
| 13 | Aliphatic polyurethane elastomers with high performance properties 显示文摘 | Byrne C A | 1987 | Polymer Engineering and Science1987，27，9： | 1 |
| 14 | Prenatal ultra- sound and fetal MRI : the comparative value of each modality in prenatal diagnosis显示文摘 | DENISE P BRUGGER P C DIETER B | 2008 | Eur J Radiol2008，68，2： | 1 |
| 15 | A GC/MS study of the drying of ballpoint pen ink on paper显示文摘 | Céline Weyermann Dieter Kirsch César Costa Vera Bernhard Spengler | 2006 | Forensic Science International2006，，2： | 1 |
| 16 | Biomechamical testing of the LCP- how can stability in locking intermal fixators be controlled 显示文摘 | Stoffel K Dieter U Stachowiak C | 2003 | Injury2003，2，： | 1 |
| 17 | Ionic structure and interactions in 1 -methyl- 3 -ethylimidazolium chlo- ride - aluminum chloride molten salts 显示文摘 | DIETER K MDYMEK C JHEIMET N E | 1988 | J Am Chem Soc1988，110，9： | 1 |
| 18 | Theoretical determination of molecular structure and conformation, stereoseleetivity of the ozonolysis reaction 显示文摘 | Dieter C | 1981 | Chem Soe1981，103，13： | 1 |
| 19 | Enzyme encapsulation in layer-by-layer engineered polymer multilayer capsules 显示文摘 | Frank C Dieter T Helmuth M | 2000 | Langmuir2000，16，4： | 1 |
| 20 | Microencapsulation of Uncharged Low Molecular Weight Organic Materials by Polyelectrolyte Multilayer Self-assembly显示文摘 | Frank C Yang W J Dieter T | 2000 | Langmuir2000，16，： | 1 |
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