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| 1 | Commercially available probiotic drinks containing Lactobacillus casei DN-114001 reduce antibiotic-associated diarrhea显示文摘AIM:To investigate the effect of Lactobacillus-containing commercially available probiotic formulations in Germany during antibiotic treatment with an analysis of cost-efficiency.METHODS:In an observational study,we analyzed the frequency of bowel movements from 258 patients with infections in a primary care hospital in western Germany;107 of the patients were offered a probiotic drink containing at least 10 billion cultures of Lactobacillus casei DN 114001 b.i.d.The economic analysis was based on the costs of patient isolation vs preventive intake of probiotics.In a second pilot study,two commercially available probiotic drinks with different Lactobacillus casei strains were directly compared in 60patients in a randomized controlled fashion.RESULTS:In the first study,the incidence of antibioticassociated diarrhea(AAD)was significantly reducedin the intervention group(6.5%vs 28.4%),and the duration of AAD in days was significantly shorter(1.7±1.1 vs 3.1±2.1).Higher age and creatinine and lower albumin were identified as risk factors for AAD.Ampicillin was the antibiotic with the highest rate of AAD(50%)and with the greatest AAD reduction in the probiotic group(4.2%,relative risk reduction 92%).The economic analysis showed a cost advantage of nearly60000€/year in a department of this size.The second study confirmed the preventive effect of the drink with Lactobacillus casei DN114001;however,there were no advantages found for the other tested probiotic drink containing Lactobacillus casei Shirota.CONCLUSION:In contrast to a drink containing Lactobacillus casei Shirota,a commercially available probiotic drink containing Lactobacillus casei DN 114001 costefficiently reduces the prevalence of AAD during antibiotic treatment. | Christoph G Dietrich Tanja Kottmann Manuela Alavi | 2014 | World Journal of Gastroenterology2014，20，42： | 14 |
| 2 | Molecular changes in hepatic metabolism and transport incirrhosis and their functional importance显示文摘Liver cirrhosis is the common endpoint of many hepatic diseases and represents a relevant risk for liver failure and hepatocellular carcinoma.The progress of liver fibrosis and cirrhosis is accompanied by deteriorating liver function.This review summarizes the regulatory and functional changes in phase Ⅰ and phaseⅡmetabolic enzymes as well as transport proteins and provides an overview regarding lipid and glucose metabolism in cirrhotic patients.Interestingly,phase Ⅰ enzymes are generally down regulated transcriptionally,while phaseⅡenzymes are mostly preserved transcriptionally but are reduced in their function.Transport proteins are regulated in a specific way that resembles the molecular changes observed in obstructive cholestasis.Lipid and glucose metabolism are characterized by insulin resistance and catabolism,leading to the disturbance of energy expenditure and wasting.Possible non-invasive tests,especially breath tests,for components of liver metabolism are discussed.The heterogeneity and complexity of changes in hepatic metabolism complicate the assessment of liver function in individual patients.Additionally,studies in humans are rare,and species differences preclude the transferability of data from rodents to humans.In clinical practice,some established global scores or criteria form the basis for the functional evaluation of patients with liver cirrhosis,but difficult treatment decisions such as selection for transplantation or resection require further research regarding the application of existing non-invasive tests and the development of more specific tests. | Christoph G Dietrich Oliver Götze Andreas Geier | 2016 | World Journal of Gastroenterology2016，22，1： | 10 |
| 3 | Percutaneous endoscopic gastrostomy—Too often?Too late?Who are the right patients for gastrostomy?显示文摘Percutaneous endoscopic gastrostomy is an established method to provide nutrition to patients with restricted oral uptake of fluids and calories.Here,we review the methods,indications and complications of this procedure.While gastrostomy can be safely and easily performed during gastroscopy,the right patients and timing for this intervention are not always chosen.Especially in patients with dementia,the indication for and timing of gastrostomies are often improper.In this patient group,clear data for enteral nutrition are lacking;however,some evidence suggests that patients with advanced dementia do not benefit,whereas patients with mild to moderate dementia might benefit from early enteral nutrition.Additionally,other patient groups with temporary or permanent restriction of oral uptake might be a useful target population for early enteral nutrition to maintain mobilization and muscle strength.We plead for a coordinated study program for these patient groups to identify suitable patients and the best timing for tube implantation. | Christoph G Dietrich Konrad Schoppmeyer | 2020 | World Journal of Gastroenterology2020，26，20： | 8 |
| 4 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D’Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 4 |
| 5 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D'Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 3 |
| 6 | Paraesophageal hernia and iron deficiency anemia:Mechanisms,diagnostics and therapy显示文摘There is ample clinical evidence suggesting that the presence of large axial or paraesophageal hernias may lead to iron deficiency anemia.So-called Cameron lesions,as well as other small mucosa erosions,in the sliding area of these diaphragmatic hernias lead to invisible chronic blood loss and consequently to iron depletion.While the spectrum of symptoms in these patients is large,anemia is often not the only indication and typically not the primary indication for surgical correction of diaphragmatic hernias.Drug treatment with proton pump inhibitors and iron substitution can alleviate anemia,but this is not always successful.To exclude other possible bleeding sources in the gastrointestinal tract,a comprehensive diagnostic program is necessary and reviewed in this manuscript.Additionally,we discuss controversies in the surgical management of paraesophageal hernias. | Christoph G Dietrich Dolores Hübner Joachim W Heise | 2021 | World Journal of Gastrointestinal Surgery2021，13，3： | 2 |
| 7 | Non-alcoholic fatty liver disease and COVID-19: Harmless companions or disease intensifier?显示文摘The pandemics of coronavirus disease 2019(COVID-19)and non-alcoholic fatty liver disease(NAFLD)coexist.Elevated liver function tests are frequent in COVID-19 and may influence liver damage in NAFLD,while preexisting liver damage from NAFLD may influence the course of COVID-19.However,the prognostic relevance of this interaction,though,is unclear.Obesity is a risk factor for the presence of NAFLD as well as a severe course of COVID-19.Cohort studies reveal conflicting results regarding the influence of NAFLD presence on COVID-19 illness severity.Striking molecular similarities of cytokine pathways in both diseases,including postacute sequelae of COVID-19,suggest common pathways for chronic low-activity inflammation.This review will summarize existing data regarding the interaction of both diseases and discuss possible mechanisms of the influence of one disease on the other. | Christoph G Dietrich Andreas Geier Uta Merle | 2023 | World Journal of Gastroenterology2023，29，2： | 2 |
| 8 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 9 | Delivery of protein antigens and DNA by virulence_attenuated strains of Salmonella typhimurium and Listeria monocytogenes显示文摘 | Dietrich G Spreng S | 2000 | J Biotechnol2000，83，： | 1 |
| 10 | Experience with registered mucosal vaccines显示文摘 | Dietrich G Griot Wenk M Metcalfe IC | 2003 | Vaccine2003，21，78： | 1 |
| 11 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D’Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 1 |
| 12 | Ultrasound of the pleurae and lungs显示文摘 | Dietrich CF Mathis G Cui XW | 2015 | Ultrasound Med Bio2015，41，2： | 1 |
| 13 | Methods and appli- cations of diffusion imagingof vertebral bone marrow 显示文摘 | Raya J G Dietrich Reiser M F | 2006 | J Magn Reson Imaging2006，24，6： | 1 |
| 14 | Myeloid sarcoma with multiple lesions of the central nervous system in a patient without leukemia 显示文摘 | Widhalm G Dietrich W Mullauer L | 2006 | J Neurosurg2006，105，6： | 1 |
| 15 | Multidrug resis-tance and response to antiretroviral treatment显示文摘 | DIETRICH C G GEIER A MATERN S | 2002 | Lancet2002，359，9323： | 1 |
| 16 | Determinants of Bank Profitability Before and during the Crisis:Evidence from Switzerland 显示文摘 | Dietrich A Wanzenried G | 2011 | Joumal of Interna-tional FinancialMarkets Institutions and Money2011，，3： | 1 |
| 17 | Selenium supple- mentatiott in patients with atttoitxtmune thyroiditis decreases thyroid peroxidase antibodies concentrations 显示文摘 | G~irtner R Gasnier BC Dietrich JW | 2002 | J Clin Endo- crinol Metab2002，87，4： | 1 |
| 18 | Pulmonary dysfunction in non-cir-rhotic patients with chronic viral hepatitis显示文摘 | Teuber G S Teupe C Dietrich C F | 2002 | Eur J Intern Med2002，13，5： | 1 |
| 19 | Antioxidant supplementation decreases lipid peroxidation biomarker F (2)-isoprostanes in plasma of smokers显示文摘 | Dietrich M Block G Hudes M | | 0，，01： | 1 |
| 20 | Delivery of DNA vaccines by attenuated intracellular bacteria显示文摘 | Gentschev I Hess J | 1999 | Trends immunology today1999，20，6： | 1 |
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