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| 1 | Outcomes of severe sepsis and septic shock patients after stratifi cation by initial lactate value显示文摘BACKGROUND: In the setting of severe sepsis and septic shock, mortality increases when lactate levels are ≥ 4 mmol/L. However, the consequences of lower lactate levels in this population are not well understood. The study aimed to determine the in-hospital mortality associated with severe sepsis and septic shock when initial lactate levels are < 4 mmol/L.METHODS: This is a retrospective cohort study of septic patients admitted over a 40-month period. Totally 338 patients were divided into three groups based on initial lactate values. Group 1 had lactate levels < 2 mmol/L; group 2: 2–4 mmol/L; and group 3: ≥ 4 mmol/L. The primary outcome was in-hospital mortality.RESULTS: There were 111 patients in group 1, 96 patients in group 2, and 131 in group 3. The mortality rates were 21.6%, 35.4%, and 51.9% respectively. Univariate analysis revealed the mortality differences to be statistically significant. Multivariate logistic regression demonstrated higher odds of death with higher lactate tier group, however the findings did not reach statistical significance.CONCLUSION: This study found that only assignment to group 3, initial lactic acid level of ≥ 4 mmol/L, was independently associated with increased mortality after correcting for underlying severity of illness and organ dysfunction. However, rising lactate levels in the other two groups were associated with increased severity of illness and were inversely proportional to prognosis. | Kimberly A. Chambers Adam Y. Park Rosa C. Banuelos Bryan F. Darge Bindu H. Akkanti Annamaria Macaluso Manoj Thangam Pratik B. Doshi | 2018 | World Journal of Emergency Medicine2018，9，2： | 26 |
| 2 | Sampling variability of liver fibrosis in chronic hepatitis C显示文摘 | Pierre Bedossa Delphine Dargère Valerie Paradis | 2003 | Hepatology2003，，6： | 6 |
| 3 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D’Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 4 |
| 4 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D'Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 3 |
| 5 | The value of the world's ecosystem services and natural capital 显示文摘 | COSTANZA R DARGE R DE G R | 1997 | Nature1997，387，： | 1 |
| 6 | The value of the worlds′ecosystem services and natural capital显示文摘 | COSTANZA R DARGE R GROOTR D | 1997 | Nature1997，387，： | 1 |
| 7 | Fortschritte in der p?diatrischen Sonographie显示文摘 | Prof. Dr. K. Darge M. Beer | 2003 | Der Radiologe2003，，10： | 1 |
| 8 | Pancreatitis and the role of US, MRCP and ERCP显示文摘 | Darge K Anupindi S | 2009 | Pediatr Radiol2009，39，2： | 1 |
| 9 | Diagnosis of vesicoureteric reflux with low-dose contrast-enhanced harmonic ultrasound imaging显示文摘 | Darge K Moeller RT Trusen A | 2005 | Pediatr Radiol2005，35，1： | 1 |
| 10 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D’Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 1 |
| 11 | Pancreatitis and the role of US, MRCP and ERCP显示文摘 | Darge K Anupindi S | 2009 | Pediatr Radiol2009，39，2： | 1 |
| 12 | Diagnostic value of spinal US: comparative study with MR imaging in pediatric patients显示文摘 | Rohrschneider WK Forsting M Darge K | 1996 | Radiology1996，200，2： | 1 |
| 13 | Differentiation of Vascular Birthmarks by MR Imaging: an Investigation of Hemangiomas,Venous and Lymphatic Malformations显示文摘 | Kern S Niemeyer C Darge K | 2000 | Acta Radiol2000，41，5： | 1 |
| 14 | Diffusion-weighted MRI for differentiation of neuroblastoma and ganglioneuroblastomal ganglioneuroma显示文摘 | Gahr N Darge K Hahn G | 2011 | EurJ Radiol2011，79，3： | 1 |
| 15 | Vosieoureteral reflux grading in contrast - enhanced voiding urosonography 显示文摘 | Darge K Troeger J | 2002 | Eur J Radial2002，43，2： | 1 |
| 16 | Ultrasound of the bowel in children: how we do it显示文摘 | Kassa Darge Sudha Anupindi Hilari Keener Oliver Rompel | 2010 | Pediatric Radiology2010，，4： | 1 |
| 17 | The value of the world's ecosystem services and natural capital显示文摘 | Costanza R dArge R de Groot R | 1997 | Nature1997，386，： | 1 |
| 18 | The value of the world's ecosystem services and natural capital 显示文摘 | COSTANZA R DARGE R DE GROOT R | 1997 | Nature1997，387，6630： | 1 |
| 19 | The value of the world's ecosystem services and natural capital显示文摘 | COSTANZA R DARGE R DE GROOT R | 1997 | Nature1997，387，6630： | 1 |
| 20 | Foreign body ingestion显示文摘 | Wunsch R Zieger B Darge K | 1999 | Radiologe1999，39，8： | 1 |
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