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| 1 | Diffusion weighted imaging in gynecological malignancies-present and future显示文摘The management of gynaecological malignancies has undergone a significant change in recent years with our improved understanding of cancer biogenetics, development of new treatment regimens and enhanced screening. Due to the rapid blooming of newer methods and techniques in gynaecology, surgery and oncology the scope and the role of imaging has also widened. Functional imaging in the form of diffusion weighted imaging(DWI) has been recently found to be very useful in assessing various tumours. Its ability to identify changes in the molecular level has dramatically changed the diagnostic approach of radiologists which was solely based on morphological criteria. It can improve the diagnostic accuracy of conventional magnetic resonance imaging, lend a hand in assessing tumour response to treatment regimens and detect tumour recurrence with better spatial resolution, negative radiation and diagnostic accuracy compared to positron emission tomography scan. The ability to quantify the diffusion has also lead to potential prediction of tumour aggressiveness and grade which directly correlate with the patient prognosis and management. Hence, it has become imperative for a radiologist to understand the concepts of DWI and its present and evolving role. In this article we present a brief description of the basics of DWI followed by its role in evaluation of female gynaecological malignancies. | Dinesh Manoharan Chandan J Das Ankita Aggarwal Arun K Gupta | 2016 | World Journal of Radiology2016，8，3： | 4 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | CD8 + Tregs in lupus,auto-immunity ,and beyond显示文摘 | Ravi K Dinesh Brian J | 2010 | Autoimmun Rev2010，9，8： | 1 |
| 4 | Availability based spare optimization using renewal process 显示文摘 | DINESH KUMAR U KNEZEVIC J | 1998 | Reliability Engineering and System Safety1998，59，： | 1 |
| 5 | Availability based spare op- timization using renewal process显示文摘 | Dinesh Kumar U Knezevic J | 1998 | Reliability Engineer ing and System Safety1998，59，2： | 1 |
| 6 | Activated carbons and low cost adsoii>ents for remediation of tri- and hexavalent chromium from water显示文摘 | Dinesh M Charles U Pittman J | 2006 | Journalof Hazardous Materials2006，132，2： | 1 |
| 7 | Transcanalicular Approach to Adult Lacrimal Duct Obstruction: A Review of Instruments and Methods显示文摘 | Athanasiov Paul A Prabhakaran Venkatesh C Mannor Geva Woog John J Selva Dinesh | 2009 | Ophthalmic Surgery Lasers and Imaging2009，，2： | 1 |
| 8 | Pyrolysis of Wood/Biomass for Bio-oil: A Critical Review显示文摘 | Dinesh Mohan Charles U Pittman J | 2006 | Energy Fuels2006，20，3： | 1 |
| 9 | Availability based spare optimization using renewal process显示文摘 | DINESH K U KNEZEVIC J | 1998 | Reliability Engineering and System Safety1998，59，： | 1 |
| 10 | Fly ash as a soil ameliorant for improving crop production - a review 显示文摘 | Sudha J Dinesh G | 2006 | Bioresouce Technology2006，97，： | 1 |
| 11 | Availability based spare optimization using renewal process显示文摘 | Dinesh Kumar U Knezevic J | 1998 | Reliability Engineering and System Safety1998，59，： | 1 |
| 12 | Activated carbons and low cost adsorbents for remediation of tri- and hexavalent chromium from water 显示文摘 | Dinesh M Charles U Pittman J | 2006 | Hazardous Materials2006，137，2： | 1 |
| 13 | Tcrpcnoid diversity in the leaf essential oils of Himalayan Lauraceae species显示文摘 | Subhash C J Rajendra C P Dinesh S B ct al | 2009 | Chemistry Biodiveritys2009，6，9： | 1 |
| 14 | Effect of Left Atrial Compliance on Pulmonary Artery Pressure:A Case Report显示文摘 | Eloi M Dinesh J Sebastian V | 2006 | Cardiovascular Ultrasound2006，4，： | 1 |
| 15 | Pyrolysis of wood/biomass for bio-oil:A critical review显示文摘 | DINESH M CHARLES U PITTMAN J | 2006 | Energy and Fuels2006，20，3： | 1 |
| 16 | Large eddy simulation of fuel variability and flame dynamics of hydrogen-enriched nonpremixed flames 显示文摘 | Ranga Dinesh K K J Jiang X Malalasekera W | 2013 | Fuel Proc- essingTechnology2013，107，： | 1 |
| 17 | Maintenancefree operating period-an alternative measure to MTBF andfailure rate for specifying reliability 显示文摘 | Dinesh Kumar U Knezevic J Crocker J | 1999 | Reliability Engi-neering System Safety1999，64，1： | 1 |
| 18 | Orbital Metastasis: Clinical Features, Management and Outcome显示文摘 | Alejandra A. Valenzuela Curtis W. Archibald Ben Fleming Lorraine Ong Brett O’Donnell John Crompton J Dinesh Selva Alan A. McNab Timothy J. Sullivan | 2009 | Orbit (-)2009，，2： | 1 |
| 19 | Availability based spare optimization using renewal process 显示文摘 | Dinesh K U Knezevic J | 1998 | Reliability Engineering and System Safety1998，59，： | 1 |
| 20 | Availability based spare optimization using renewal process显示文摘 | Dinesh Kumar U Knezevic J | 1998 | Reliability Engineering and System Safety1998，59，2： | 1 |
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