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| 1 | 【特刊综述】雄激素对骨骼肌的作用:对乏力的发展和治疗的意义显示文摘雄激素对骨骼肌合成有明显影响,随着年龄增大,雄激素的下降常伴随肌量和肌力的下降。这种肌量和肌功能的下降,被称为少肌症或肌体老化,是老年人体质弱化(男性化减退)进展的关键事项。也是导致快速机能衰退及其不良后果的关键。雄激素水平下降对老年男性体质弱化(男性化减退)的潜在影响和对躯体功能的促进治疗作用无疑已经引起了相当的关注。本综述概述了近期关于肌肉老化、少肌症、老年体质弱化的概念、定义,并评估了关于雄激素和老年体质弱化的研究进展。近期源于观测性和介入性研究的证据强烈支持雄激素对老年男性肌量的作用,但雄激素对肌力和特有的躯体功能的效用并不明确。研究显示,雄激素治疗在老年男性中通常有良好的耐受性,而近期的研究则关注于雄激素的高剂量治疗和对于心血管风险较高人群的治疗。雄激素受体调节剂(SARMs)的初期试验研究显示传统雄激素治疗对于老年患者在肌量和肌功能方面有相同的效用。将来的重要研究方向包括利用这类雄激素治疗并结合适用于不同老年患者群体促进躯体功能的运动训练,同时将更多地关注近期关于激素水平、身体成分及躯体功能间关系的观测性(回顾性)研究。 | Matthew DL O'Connell Frederick CW Wu | 2014 | Asian Journal of Andrology2014，16，2： | 2 |
| 2 | Frequency of esophageal stenosis after simultaneous modulated accelerated radiation therapy and chemotherapy for head and neck cancer 显示文摘 | JOSHUA DL KRISTEN O WILLIAM G | 2008 | American Journal of Otolaryngology2008，29，1： | 1 |
| 3 | Targeted tuberculin tes- ting and treatment of latent tuberculosis infection显示文摘 | Cohn DL O' Brien R J Geiter LJ | 2000 | Am J Respir Crit Care Med2000，161，4： | 1 |
| 4 | Iterative deblurring for CT metal artifact reduction显示文摘 | Wang G Snyder DL O'sullivan JA | 1996 | IEEE Transactions on Medical Imaging1996，15，5： | 1 |
| 5 | Cancer incidence in people with hepatitis B or C infection: a large community-based linkage study显示文摘 | Amin J Dore GJ O'Connell DL | 2006 | J Hepatol2006，45，： | 1 |
| 6 | Distribution of iodized oil with the liver after hepatic artery injection显示文摘 | Miller DL O'Leary TJ Girton M | 1987 | Radiology1987，162，3： | 1 |
| 7 | Prediction of glycemic index for starchy foods显示文摘 | Trout DL Behall KM Osilesi O | 1993 | Am J Clin Nutr1993，58，6： | 1 |
| 8 | Molecular imprinting in sol - gel materials: recent developments and applica- tions显示文摘 | Dl'az-Garcl'a ME Lal'n - o RB | 2005 | Microehim Acta2005，，12： | 1 |
| 9 | Refrigeration system dynam- ics during the reverse cycle defrost 显示文摘 | O' Neal DL Peterson KT | 1989 | ASHRAE Transactions1989，95，2： | 1 |
| 10 | The impact of substance abuse on mortality in patients with severe traumatic brain injury显示文摘 | O'Phelan K McArthur DL Chang CW | 2008 | J Trauma2008，65，3： | 1 |
| 11 | Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy显示文摘 | Fakhrai H Dorigo O Shawler DL | 1996 | Proc Natl Acad Sci U S A1996，93，7： | 1 |
| 12 | N-acetyl cysteine for depressive symptoms in bipolar disorder a double-blind randomized placebo-controlled triM显示文摘 | Berk M Copolov DL Dean O | 2008 | Biol Psychiatry2008，64，6： | 1 |
| 13 | Relativebioavailability of iron and folic acid from a new powdered supple-ment compared to a traditional tablet in pregnant women显示文摘 | Hartman-Craven B Christofides A O'Connor DL | 2009 | BMCPregnancy Childbirth2009，9，： | 1 |
| 14 | Alteration of hepatic fatty acid metabolism after bum injury in pigs 显示文摘 | Martini WZ Irtun O Chinkes DL | 2001 | JPEN J Parenter Enteral Nutr2001，25，： | 1 |
| 15 | An analysis of the natural history of cavernous angiomas显示文摘 | Del Curling O Jr Kelly DL Jr Elster AD | 1991 | J Neurosurg1991，75，5： | 1 |
| 16 | Growth and nutrientin takes of human milk-fed preterm infants provided withextra energy and nutrients after hospital discharge显示文摘 | O′Connor DL Khan S Weishuhn K | 2008 | Pediat-rics2008，121，4： | 1 |
| 17 | Finding solu- tions to the rural doctor shortage:the roles of selection versus undergraduate medical education at Newcastle 显示文摘 | Rolfe IE Pearson SA O'Connell DL | 1995 | Aust N Z J Med1995，25，5： | 1 |
| 18 | Benign breast dis-ease,mammographic breast density,and the risk of breast cancer 显示文摘 | Tice JA O’Meara ES Weaver DL | 2013 | NCI2013，105，14： | 1 |
| 19 | Pathways mediating the interaction between endothelial progenitor cells (EPCs) and platelets显示文摘 | Raz O Lev DL Battler A | 2014 | PLoS One2014，9，95： | 1 |
| 20 | Effect of a low glycaemic index diet on blood glucose in women with gestational hyperglycaemia显示文摘 | Grant SM Wolever TM O'Connor DL | 2011 | Diabetes Res Clin Pract2011，91，1： | 1 |
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