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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | 基于计算试验设计与代理模型的飞行器近似优化策略探讨显示文摘现代飞行器设计优化中广泛应用高精度分析模型以提高设计可信度与综合性能,但是也带来了计算复杂性问题。为了有效缓解计算耗时的问题,基于计算试验设计与代理模型的飞行器近似优化策略成为研究热点。近似优化策略通过构造合理的近似模型引导优化过程快速收敛到最优解,从而达到降低计算成本,缩短设计周期的目的。根据广泛的文献调研,对飞行器近似优化策略的发展现状进行详细探讨。给出近似优化策略的定义、求解流程、特点以及关键技术。对计算试验设计方法、代理模型方法、精度校验与代理模型选择方法等技术进行综述。围绕静态与自适应两类近似优化策略,重点讨论典型的代理模型管理与更新策略与收敛准则。针对飞行器多学科设计优化问题,探讨近似优化策略与分解策略在求解效率与收敛性方面的技术特点。通过数值算例对各项关键技术的特点进行较详尽的对比分析与总结,并依托飞行器设计优化工程实例对近似优化策略的综合性能进行探讨,指出不同近似优化策略的适用范围。研究结果表明,飞行器近似优化策略在优化效率、全局收敛性以及鲁棒性等方面体现出较显著的优势,具有良好的工程应用前景。指出飞行器近似优化策略的未来研究方向。 | 龙腾 刘建 WANG G Gary 刘莉 史人赫 郭晓松 | 2016 | 机械工程学报2016，52，14： | 69 |
| 3 | Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis显示文摘尖锐心肌的梗塞(AMI ) 是一个威胁生活的事件。甚至与及时处理,尖锐 ischemic 心肌的损害和随后的局部缺血灌注损害(IRI ) 能仍然是困难的问题处理。除了放射学并且另外的辅助考试,适用的心脏的 biomarkers 的实验室测试为这混乱监视的早诊断和结束也是必要的。心类型丰满的酸绑定蛋白质(H-FABP ) 主要在 cardiomyocytes 内存在,最近为心肌的损害作为潜在地有希望的 biomarker 出现了。在这评论,我们在对心肌的损害和 IRI 的评价讨论 H-FABP 的敏感和特性,特别在早阶段,和它与另外的通常使用的心脏的 biomarkers 比较的长期的预示的价值,包括肌球素( Mb ),心脏的 troponin 我( cTnI ),肌酸 kinase MB ( CK-MB ),C反应的蛋白质( CRP ),肝糖 phosphorylase isoenzyme BB ( GPBB ),和高敏感的心脏的 troponin T ( hs-cTnT )。有另外的 biomarkers 的 H-FABP 的联合申请的潜力和值也被讨论。最后, H-FABP 的前景被总结;几个技术问题被讨论在临床的实践便于 H-FABP 的更宽的申请。 | Xiao-dong YE Yi HE Sheng WANG Gordon T WONG Michael G IRWIN Zhengyuan XIA | 2018 | Acta Pharmacologica Sinica2018，39，7： | 72 |
| 4 | SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway显示文摘当严重急性呼吸症候群日冕病毒(SARS-CoV ) 开始被认为与质膜通过直接熔化进入房间时,更最近的证据建议那个病毒条目可以也包含 endocytosis。我们发现了那 SARS-CoV 进入房间经由 pH 依赖并且受体依赖者 endocytosis。有任何一个 SARS-CoV 尖铁蛋白质或忍受尖铁的假病毒的房间的治疗导致了变换血管收缩素的酶的 translocation 2 (ACE2 ) , SARS-CoV 的功能的受体,从房间表面到内涵体。另外,忍受尖铁的假病毒和 1 在内涵体被发现到 colocalize 的早内涵体抗原。用象 caveolin-1 colocalization 学习一样的特定的 endocytic 小径禁止者和主导否定的 Eps15 的进一步的分析建议那个病毒条目被 clathrin 独立、 caveolae 独立的机制调停。而且,在质膜的微域,它被显示出到为许多生理的发信号小径作为平台扮演的充满胆固醇、 sphingolipid 富有的类脂化合物木排,被显示涉及病毒入口。SARS-CoV 的 Endocytic 入口可以扩展这里的 SARS-CoV 感染,和我们的调查结果的细胞的范围贡献 SARS-CoV 致病的理解,为抗病毒的药研究提供新信息。 | Wang,H Yang,P Liu,K Guo,F Zhang,Y Zhang,G Jiang,C | 2008 | Cell Research2008，18，2： | 50 |
| 5 | Tectonic evolution of the Dabieshan orogen: In the view from polyphase deformation of the Beihuaiyang metamorphic zone显示文摘The Beihuaiyang metamorphic zone was formed by the Early Mesozoic collision of the North and South China Blocks. It consisted of the Foziling and Luzhenguan complexes and was thought to have never afforded a deep subduction. A similar feature of the deformation in the Dabieshan UHP metamorphic rocks implies that these different tectonic units share the same geodynamic background. The early stage of deformation can be preserved on account of their relatively shallower subduction than that for UHP rocks. On the basis of an analysis of the geo- logical structure and geochronological results, five deformational stages have been recognized: a D1-Early compressional deformation which represents the continental subduction; a D2-Early exhumation deformation producing a syn-convergence exhumation; a D3-Main deformation, represented by an exhumation deformation with Late Triassic age; a D4-Doming and its margin extensional gravity collapse deformation and finally a D5-regional extensional deformation of Cretaceous that was mostly introduced by the migmatization and plutonism. | LIN Wei1, 2, Faure Michel3, WANG Qingchen1 & Arnaud Nicolas4 1. LTE, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 2. Department of Earth and Planetary Sciences, Graduate School of Science, Nagoya University, Japan 3. ISTO, UMR CNRS 6113, Batiment Géosciences, Orléans Université d’Orléans, 45067 Orléans Cedex 2, France 4. UMR 6524 'Magmas et Volcans', 5 Rue Kessler, 63000 Clermont-Ferrand, France | 2005 | Science China Earth Sciences2005，48，7： | 25 |
| 6 | ^(40)Ar-^(39)Ar ages of the Louzidian-Dachengzi ductile shear zone near Chifeng,Inner Mongolia and their tectonic significance显示文摘The Louzidian normal fault occurs as the eastern detachment fault of the Kalaqin metamorphic core complex. Field observations and microstructural analyses reveal that the Louzidian-Dachengzi ductile shear zone developed in its lower-plate was genetically related to sinistral strike-slips and extensional faulting. Two samples from this ductile shear zone yield 40Ar-39Ar plateau ages of 133 Ma (Bi) and 126 Ma (Kp), which are concordant with their isochron ages. The plateau age of 133 Ma (Bi) records the formation age of the ductile shear zone. The inconsistent relationship between the earlier strike-slip ductile shear zone and the later normal fault makes the Kalaqin Quasi-metamorphic core complex distinctive from Cordil-leran nietamorphic core complex. These ages provide important geochronological data for putting constraints on the formation age and genesis of such ductile shear zones. | ZHANG Xiaohui, LI Tiesheng, PU Zhiping & WANG HuiResearch Center for Mineral Resources Exploration, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100101, China Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, G | 2002 | Chinese Science Bulletin2002，47，15： | 21 |
| 7 | 基于评价者视角的组织合法性研究:合法性判断显示文摘作为分析和解释组织行为的一个有力工具,组织合法性逐渐成为了组织研究者们关注的热点话题。迄今为止,学者们主要从三条路径来开展对组织合法性的探讨:制度路径、战略路径和评价者路径。评价者路径是组织合法性研究的新动向和新视角,该路径的核心概念为合法性判断,即评价者围绕特定组织是否具有合法性所进行的自我判断。本文阐明了合法性判断的概念内涵,分析了合法性判断的判断模式与评价视角、合法性判断的心理历程以及合法性判断理论的应用价值,最后进行了合法性判断理论的研究展望。 | 刘云 Wang G Greg | 2017 | 外国经济与管理2017，39，5： | 19 |
| 8 | 多学科合作下糖尿病足防治专家共识(2020版)显示文摘糖尿病足是糖尿病患者致残致死的主要原因之一,同时也给社会、家庭带来严重的经济负担。自2005年世界糖尿病日关注糖尿病足部管理开始,各国更加注重糖尿病足的诊疗并制定了一系列诊疗指南。目前我国也有几部糖尿病足指南发布,对规范医疗起到了极大的作用。 | Wang A Lv G Cheng X | 2020 | 中华烧伤杂志2020，36，10： | 18 |
| 9 | Role of ethanol in the regulation of hepatic stellate cell function显示文摘Evidence has accumulated to suggest an important role of ethanol and/or its metabolites in the pathogenesis of alcohol-related liver disease. In this review, the fibrogenic effects of ethanol and its metabolites on hepatic stellate cells (HSCs) are discussed. In brief, ethanol interferes with retinoid metabolism and its signaling, induces the release of fibrogenic cytokines such as transforming growth factor β-1 (TGFβ-1) from HSCs, up-regulates the gene expression of collagen I and enhances type I collagen protein production by HSCs. Ethanol further perpetuates an activated HSC phenotype through extracellular matrix remodeling. The underlying pathophysiologic mechanisms by which ethanol exerts these pro-fibrogenic effects on HSCs are reviewed. | Jian-Hua Wang Robert G Batey Jacob George | 2006 | World Journal of Gastroenterology2006，12，43： | 16 |
| 10 | Molecular organic geochemical evidence for paleoenvironmental changes at 11.87—12.28 m in GS-1 sedimentary core,Gucheng Lake,East China显示文摘Organic lipids with different occurrence modes in a sedimentary core in a subtropicalfreshwater lake, Gucheng Lake, were sequentially extracted, separated and analyzed. Thedown-core variations of OEP index of alkanes, C18:2/C18:0 ratios of fatty acids, ratios of boundfatty acids to free fatty acids, thermo-maturity indices of hopanoid hydrocarbons and relativeconcentrations of sedimentary minerals revealed an evident increasing in allochthonous inputfrom rock detritus below 12.28 m in the sedimentary profile. The distribution pattern of tightly-bound β-hydroxy fatty acids indicated a difference in bacterial communities above and below theboundary, as well as the gammacerane index may assign a significant change in lake watersalinity. The evidence, in general, suggested that a significant paleoenvironmental change hadtaken place in ca. 9.6 kaBP on the regional basis. | Zhang, G Sheng, GY Fu, JM Wang, SM | 1999 | Chinese Science Bulletin1999，44，15： | 15 |
| 11 | The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells显示文摘The herbal medicine Tong Luo Jiu Nao(TLJN)contains geniposide(GP)and ginsenoside Rg1 at a molar ratio of 10:1.Rg1 is the major component of another herbal medicine,panax notoginseng saponin(PNS).TLJN has been shown to strengthen brain function in humans,and in animals it improves learning and memory.We have previously shown that TLJN reduces amyloidogenic processing in Alzheimer’s disease(AD)mouse models.Together this suggests TLJN may be a potential treatment for patients with dementia.Because chronic damage of the central nervous system by formaldehyde(FA)has been presented as a risk factor for age-associated cognitive dysfunction,in the present study we investigated the protective effect of both TLJN and GP in neuron-like cells exposed to FA.FA-exposed murine N2a neuroblastoma cells were incubated with TLJN,its main ingredient GP,as well as PNS,to measure cell viability and morphology,the rate of apoptosis and expression of genes encoding Akt,FOXO3,Bcl2 and p53.The CCK-8 assay,cytoskeletal staining and flow cytometry were used to test cell viability,morphology and apoptosis,respectively.Fluorescent quantitative real-time PCR(qRT-PCR)was used to monitor changes in gene expression,and HPLC to determine the rate of FA clearance.Treatment of N2a cells with 0.09 mmol L?1 FA for 24 h significantly reduced cell viability,changed cell morphology and promoted apoptosis.Both TLJN and GP conferred neuroprotection to FA-treated N2a cells,whereas PNS,which had to be used at lower concentrations because of its toxicity,did not.Our data demonstrate that TLJN can rescue neuronal damage caused by FA and that its main ingredient,GP,has a major role in this efficacy.This presents purified GP as a drug or lead compound for the treatment of AD. | CHEN JinYan SUN MengRu WANG XingHua LU Jing WEI Yan TAN Yan LIU Ying GTZ Jürgen HE RongQiao HUA Qian | 2014 | Science China(Life Sciences)2014，57，4： | 15 |
| 12 | 基质金属蛋白酶1的组织抑制剂通过介导CD63与整合素β_1的相互作用促进心肌纤维化显示文摘心肌纤维化指细胞外基质纤维胶原蛋白的过度积累。纤维化是各种心肌病的关键特征,会影响心脏收缩和舒张功能。金属蛋白酶1组织抑制剂(tissue inhibitor of metalloproteinase-1,TIMP1)水平在心肌纤维化过程中始终增加,被认为是纤维化的标记物。 | Takawale A Zhang P Patel VB Wang X Oudit G Kassiri Z 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，4： | 13 |
| 13 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 14 | Characteristic-based operator-splitting finite element method for Navier-Stokes equations显示文摘A new finite element method, which is the characteristic-based operator-splitting (CBOS) algorithm, is developed to solve Navier-Stokes (N-S) equations. In each time step, the equations are split into the diffusive part and the convective part by adopting the operator-splitting algorithm. For the diffusive part, the temporal discretization is performed by the backward difference method which yields an implicit scheme and the spatial discretization is performed by the standard Galerkin method. The convective part can be discretized using the characteristic Galerkin method and solved explicitly. The driven square flow and backward-facing step flow are conducted to validate the model. It is shown that the numerical results agree well with the standard solutions or existing experimental data, and the present model has high accuracy and good stability. It provides a prospective research method for solving N-S equations. | WANG DaGuo WANG HaiJiao XIONG JuHua THAM L G | 2011 | Science China(Technological Sciences)2011，54，8： | 13 |
| 15 | Calcium signaling and T-type calcium channels in cancer cell cycling显示文摘Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers. | James T Taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang Stephenie G Yi lennifer A S Scruggs Suresh S Sikka Ming Li | 2008 | World Journal of Gastroenterology2008，14，32： | 12 |
| 16 | 为什么附睾肿瘤这么稀少?显示文摘附睾癌的发病率最多不超过所有男性癌症的0.03%。人类附睾亦可以表达干细胞和癌细胞的标记,基础表达致癌基因及那些让肿瘤细胞在易患癌的组织中逃避免疫监视的促增殖的和促血管生成的因子,但为什么它却可以不屈服于癌症呢?这是一个谜。人类附睾可逃避肿瘤发生的特殊功能在转基因小鼠模型上得到验证。其它的器官都可以被诱导发生肿瘤,唯独附睾中没有。看来附睾可以:(一)防止肿瘤发生(它可能没有干细胞,并具有较强的抗氧化机制,有效的肿瘤抑制基因和无效的致癌基因产品);(二)监控肿瘤和并破坏肿瘤(通过强大的免疫监视、免疫清除及细胞衰老);(三)避开增殖和血管生成(持久的细胞紧密连接,抗血管生成因子、错位的促血管形成因子的存在);(四)加速休眠和限制细胞分裂增生。附睾细胞可能对通常诱导肿瘤基础表达的因子的致癌刺激物无响应,也能抵抗正常的模拟了促进肿瘤生长的环境。因此附睾中肿瘤发生的阈值就可能要高于其他器官。一些抗肿瘤机制是维持精子静态和免疫沉默。因此附睾癌的发病率较低,可能是因为其在精子成熟和储存中扮演着其它的角色的关系。了解这些机制可以给一般癌症的预防和治疗带来一些启示。 | Ching-Hei Yeung Kai Wang Trevor G Cooper | 2012 | Asian Journal of Andrology2012，14，3： | 11 |
| 17 | Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro显示文摘 | Lian G Wang C Teng C Zhang C Du L Zhong Q Miao C Ding M Deng H | 2006 | 中国生物学文摘2006，20，5： | 11 |
| 18 | Chemical composition of gas from mantle xenoliths in alkali- basalt from Damaping, Hebei显示文摘WE have measured the chemical composition of the gas extracted from ortho- and clino-pyroxenes in spinel lherzolite xenolith, and from black pyroxenolite xenolith in Cenozoic alkah-basalt from Damáping, Wanquan County, Hebei Province, by pyrolystic method. | Liu, G Wang, XB Li, LW | 1997 | Chinese Science Bulletin1997，42，6： | 11 |
| 19 | Compliance Analysis of a 3-DOF Spindle Head by Considering Gravitational Effects显示文摘The compliance modeling is one of the most significant issues in the stage of preliminary design for parallel kinematic machine(PKM). The gravity ignored in traditional compliance analysis has a significant effect on pose accuracy of tool center point(TCP) when a PKM is horizontally placed. By taking gravity into account, this paper presents a semi-analytical approach for compliance analysis of a 3-DOF spindle head named the A3 head. The architecture behind the A3 head is a 3-RPS parallel mechanism having one translational and two rotational movement capabilities, which can be employed to form the main body of a 5-DOF hybrid kinematic machine especially designed for high-speed machining of large aircraft components. The force analysis is carried out by considering both the externally applied wrench imposed upon the platform as well as gravity of all moving components. Then, the deflection analysis is investigated to establish the relationship between the deflection twist and compliances of all joints and links using semi-analytical method. The merits of this approach lie in that platform deflection twist throughout the entire task workspace can be evaluated in a very efficient manner. The effectiveness of the proposed approach is verified by the FEA and experiment at different configurations and the results show that the discrepancy of the compliances is less than 0.04 μm/N-1 and that of the deformations is less than 10μm. The computational and experimental results show that the deflection twist induced by gravity forces of the moving components has significant bearings on pose accuracy of the platform, providing an informative guidance for the improvement of the current design. The proposed approach can be easily applied to the compliance analysis of PKM by considering gravitational effects and to evaluate the deformation caused by gravity throughout the entire workspace. | LI Qi WANG Manxin HUANG Tian CHETWYND G Derek | 2015 | Chinese Journal of Mechanical Engineering2015，28，1： | 11 |
| 20 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
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