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| 1 | Bone cemen textracts modulate the osteoprotegerin/osteoprotegerin ligand expressionin MG63 osteoblast-like cells显示文摘 | Donatella G Elisabetta C Lucia S | 2002 | Biomaterials2002，23，15： | 1 |
| 2 | An extende-UIO-base methord for protocol conformance testing显示文摘 | GIACOMO B FRANCO F DONATELLA S | 2000 | Journal of Ststems Architecture2000，46，： | 1 |
| 3 | Effect of tributyltin on trout blood cells:changes in mitochondrial morphology and functionality显示文摘 | Luca T Donatella F Giorgio S | 2003 | Biochimica et Biophysica Acta (BBA)/Molecular Cell Research2003，1640，： | 1 |
| 4 | Antimicrobial peptides from skin secretions of Rana esculenta显示文摘 | Maurizio S Giuseppina M Donatella B | 1993 | Biol Ghem1993，269，11： | 1 |
| 5 | Activation of the ERK/MAP kinase pathway in cervical Intraepithelial neoplasia is related to grade of the lesion but not to high-risk human papillomavirus,virus clearance,or prognosis in cervical cancer显示文摘 | Margherita B Marco C Donatella S | 2004 | American Journal of Clinical Pathology2004，122，6： | 1 |
| 6 | Growth factors sustain primordial germ cell survival, proliferation and entering into meiosis in the absence of somatic cells 显示文摘 | Donatella F Maria L S Saveria I | 2005 | Dev Biol2005，285，1： | 1 |
| 7 | A Review of Modelsand Micrometeorological Methods Used to Estimate WetlandEvapotranspiration显示文摘 | Judy Z D Richard L S Donatella S | 2004 | Hydrological Process2004，18，： | 1 |
| 8 | Solid-papillary tumors of the pancreas: histopathology显示文摘 | Donatella S Francesca P Stefania L | 2006 | J Pancreas2006，7，1： | 1 |
| 9 | Nitric oxide-mediated induction of ferritin synthesis in J774 macrophages by inflammatory cytokines:Role of selective Iron regulatory protein-2 downregulation显示文摘 | Donatella T Dario C | 1998 | Blood1998，91，3： | 1 |
| 10 | Vulnerability to ventricular arrhythmias and heterogeneity of action potential duration innormal rats显示文摘 | Donatella S Roberta B Leonardo B | 2004 | Exp Physiol2004，89，4： | 1 |
| 11 | In vitro antimycoplasmal activity of Melaleuca alternifolia essential oil显示文摘 | Pio MF Donatella P Antonella S | 2006 | J Antimicrob Chemother2006，58，3： | 1 |
| 12 | Influence of postharvest chitosan treatment on enzymatic browning and antioxidant enzyme activity in sweet cherry fruit显示文摘 | Maria S P Donatella D Francesco M Luigi Z Marco S Milena P | 2015 | Postharvest Biology and Technology2015，109，11： | 1 |
| 13 | Insulin resis-tance of stress: sites and mechanisms显示文摘 | Luigi S Brandi Donatella Santoro Andrea Natali | 1993 | Clin Sci1993，85，： | 1 |
| 14 | A48G polymorphism in the D1 receptor genes associated with bipolar I disorder显示文摘 | Giovanni S Donatella C Claudia S | 2005 | American Journal of Medical Genetics Part B (Neuropsychiatric Genetics)2005，134，1： | 1 |
| 15 | Atetrmeric iron superoxide dismutaser from the eukaryote Tetrahymena pyri-/ormw显示文摘 | Donatella B Eugenia M S Franeeseo B | 1990 | J Biol Chem1990，265，17： | 1 |
| 16 | Solid - papillary tumors of the pancreas : histopathology 显示文摘 | Donatella S Francesca P Stefania L | 2006 | J Pancreas2006，7，1： | 1 |
| 17 | Growth factors sustain primordial germ cell survival,proliferation and entering into meiosis in the absence of somatic cells显示文摘 | Donatella F Maria L S Saveria I | 2005 | Developmental Biology2005，，285： | 1 |
| 18 | Effect of tributyltin on trout blood cells: changes in mitochondrial morphology and functionality 显示文摘 | Luca T Donatella F Giorgio S | 2003 | Riochimica et Biophysica Acta (BBA)/Molecular Cell Research2003，1640，： | 1 |
| 19 | Implantable(Bio)sensors as new tools for wireless monitoring of brain neurochemistry in real time显示文摘Implantable electrochemical microsensors are characterized by high sensitivity, while amperometric biosensors are very selective in virtue of the biological detecting element. Each sensor, specific for every neurochemical species, is a miniaturized hightechnology device resulting from the combination of several factors: electrode material, shielding polymers, applied electrochemical technique, and in the case of biosensors, biological sensing material, stabilizers, and entrapping chemical nets. In this paper, we summarizethe available technology for the in vivo electrochemical monitoring of neurotransmitters(dopamine, norepinephrine, serotonin, acetylcholine, and glutamate), bioenergetic substrates(glucose, lactate, and oxygen), neuromodulators(ascorbic acid and nitric oxide), and exogenous molecules such as ethanol. We also describe the most represented biotelemetric technologies in order to wirelessly transmit the signals of the abovelisted neurochemicals. Implantable(Bio)sensors, integrated into miniaturized telemetry systems, represent a new generation of analytical tools that could be used for studying the brain's physiology and pathophysiology and the effects of different drugs(or toxic chemicals such as ethanol) on neurochemical systems. | Donatella Farina Maria D Alvau Giulia Puggioni Giammario Calia Gianfranco Bazzu Rossana Migheli Ottavio Sechi Gaia Rocchitta Maria S Desole Pier Andrea Serra | 2014 | World Journal of Pharmacology2014，3，1： | 0 |
| 20 | Locoregional therapy and systemic cetuximab to treat colorectal liver metastases显示文摘AIM: To investigate efficacy and safety of second-line treatment with irinotecan-loaded drug-eluting beads(DEBIRI) and cetuximab(DEBIRITUX) of unresectable colorectal liver metastases.METHODS: Patients with the following characteristics were included in the study: unresectable hepatic metastases from colorectal carcinoma(CRC-LM), progression after first line chemotherapy(any type of chemotherapeutic drug and combination was allowed), second line treatment(mandatory), which included for each patient(unregarding the KRas status) two cycles of DEBIRI(using 100-300 μm beads loaded with irinotecan at a total dose 200 mg) followed by 12 cycles of cetuximab that was administered weekly at a first dose of 400 mg/m2 and then 250 mg/m2; good performance status(0-2) and liver functionality(alanine aminotransferase and gamma-glutamyl transferase not exceeding three times the upper limit of normal, total bilirubin not exceeding 2.5 mg/m L). Data were collected retrospectively and included: tumor response(evaluated monthly for 6 mo then every 3 mo), overall response rate(ORR), KRas status, type and intensity of adverse events(G according to the Common Terminology Criteria for Adverse Events v3.0, CTCAE), overall survival(OS) and progression free survival(PFS).RESULTS: Forty consecutive cases of CRC hepatic metastases were included in the study. Median duration of DEBIRITUX was 4.4 mo(range, 4.0-6.5). Sixteen patients(40%) received the planned 2 cycles of DEBIRI and an average of 10 cetuximab cycles. ORR of the whole sample was 50%, in particular 4 patients were complete responders(10%) and 16(40%) partial responders. The most observed side effects(G2) were: post-embolization syndrome(30%), diarrhea(25%), skin rushes(38%) and asthenia(35%). The retrospective evaluation of KRas status(24 wild type, 16 mutated) showed that the group of patients with wild type KRas had ORR significantly higher than mutant KRas. Median follow-up was 29 mo(8-48 range); median PFS was 9.8 mo and OS was 20.4 mo. Future randomized trials are required in this setting to establish a role for DEBIRITUX compared with systemic chemotherapy.CONCLUSION: DEBIRITUX seems to be efficacious after first line chemotherapy for the treatment of unresectable CRC-LM. | Giammaria Fiorentini Camillo Aliberti Donatella Sarti Paolo Coschiera Massimo Tilli Luca Mulazzani Paolo Giordani Francesco Graziano Alfonso Marqués Gonzalez Raul García Marcos Fernando Gómez Mugnoz Maurizio Cantore Stefano Ricci Vincenzo Catalano Andrea Mambrini | 2015 | World Journal of Gastrointestinal Oncology2015，7，6： | 0 |
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