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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Three-dimensional structural changes in living hippocampal neurons imaged using magnetic AC mode atomic force microscopy.显示文摘 | Yunxu S Danying L Yanfang R Dong H Wanyun M | 2006 | 中国生物学文摘2006，20，9： | 7 |
| 3 | Electronic structure and optical properties of the Co-doped anatase TiO2 studied from first principles 显示文摘 | Weng H M Yang X P Dong J M | 2004 | Phys Rev2004，69，12： | 1 |
| 4 | Additive Effect of Adenovi-rus-Mediated E2F-1 Gene Transfer and Topoisomerase ]I Inhibi-tors on Apoptosis in Human Osteosarcoma Cells显示文摘 | Yang H L Dong YB Elliott M J | 2001 | Cancer GeneTher2001，8，4： | 1 |
| 5 | Research on aging precipitation in a Cu-Cr-Zr-Mg alloy显示文摘 | Su J H Dong Q M Liu P | 2005 | Mater Sci Eng2005，392，： | 1 |
| 6 | Recognition of HLA-A3 and HLA-A11 by KIR3DL2 is peptide-specific显示文摘 | Hansasuta PT Dong H Thananchai M | 2004 | Eur J Immunol2004，34，6： | 1 |
| 7 | Effects of sand burial on the survival, growth and biomass allocation in semi-shrub Hedysarum lacre seedlings显示文摘 | Zhang C Y Yu F H Dong M | 2002 | Acta Bat Sin2002，44，3： | 1 |
| 8 | Roles of SM22ct in cellular plasticity and vascular diseases 显示文摘 | Dong L H Lv P Han M | 2012 | Cardiovas Hematol Disord Drug Targets2012，12，2： | 1 |
| 9 | Overvalued equity and financing decisions 显示文摘 | DONG M HIRSHLEIFER D TEOH S H | 2012 | Review of Financial Studies2012，25，12： | 1 |
| 10 | Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer' s disease显示文摘 | Dong H Csemansky C A Martin M V | | 0，，： | 1 |
| 11 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 12 | Chemical assessment of roots of Panax notoginseng in China : regional and seasonal varia- tions in its active constituents 显示文摘 | DONG T X CUI X M SONG Z H | 2003 | J Agric Food Chem2003，51，16： | 1 |
| 13 | Protective effect of N-acetyl-L-cysteine on amyloid beta-peptide-induced learning and memory deficits in mice显示文摘 | Fu A L Dong Z H Sun M J | 2006 | Brain Res2006，1109，1： | 1 |
| 14 | Apparent protein digestibility and mineral availabilities in various feed ingredients for salmonid feeds显示文摘 | Sugiura S H Dong F M Rathbone C K | 1998 | Aquaculture1998，159，： | 1 |
| 15 | Subcellular co-localization of Arabidopsis RTE1 and ETR1 supports a regulatory role for RTE1 in ETR1 ethylene signaling显示文摘 | Dong C H Rivarola M Resnick J S | 2008 | Plant J2008，53，2： | 1 |
| 16 | From clusters to phase diagrams: Composition rules of quasicrystals and bulk metallic glasses 显示文摘 | DONG C WANG Q QIANG J B WANG Y M JIANG N HAN G LI Y H WU J XIA J H | 2007 | J Phys D: Appl Phys2007，40，： | 1 |
| 17 | Effect of heat treatment on mierostructure and mechanical properties of Cr Ni Mo Nb steel显示文摘 | Wang M Q Dong H Hui W J | 2007 | Materials Science and Technology2007，23，8： | 1 |
| 18 | A review of formation mechanism and restoration measures of 'black soil-type' degraded grassland in the Qinghai-Tibetan Plateau显示文摘 | Dong Q M Zhao X Q Wu G L Shi J J Ren G H | 2013 | Environmental Earth Sciences2013，70，5： | 1 |
| 19 | Novel M(II)-Hg(II) coordination polymers generated from metal-containing building blocks M (2-pyrazineearboxyliate)2 '(H2O)2 (M=Cu,Ni,Co)and HgCl2显示文摘 | Dong Y B Smith M D zur Loye H C | 2000 | Solid State Sci2000，，2： | 1 |
| 20 | 显示文摘 | Dong L Shen M | 2001 | Appl Catal B: Environ2001，31，： | 1 |
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