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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Late Cretaceous biota and the Cretaceous-Paleogene(K--Pg)Boundary in Jiayin of Heilongjiang,China显示文摘An international cooperative study of the Late Cretaceous biota and non-marine strata including the Cretaceous-Paleogene(K--Pg) boundary in Jiayin near the Heilongjiang River,China during 2002-2010,is summarized in this paper. The strata includes the Upper Cretaceous Yong'ancun-,Taipinglinchang-,Yuliang-zi-,and Furao formations,and the Paleocence Wuyun Formation consisting of Baoshantou Member and a Coalbearing Member. Seven palynological assemblages from Santonian to Paleocene are recognized,which is used for definition of the K--Pg boundary. Through the palynological analysis of three drilled boreholes (XHY-2005,2006,2008) in Xiaoheyan of western Jiayin,the K--Pg boundary is defined within 20. 00-20. 05 m in the borehole XHY-2006 (as a standard boundary) which is just between the top of Furao Formation (late Maasterichtian) and the base of Baishantou Member (early Danian) . These new research results are supported by paleo- magnetic,geochemical and other analyses,also. On the other hand,the presence of eight taxa of Maasterichtian dinosaurs (mostly hadrosaurids) have been recognized by the authors; and two mega-plant assemblages from the Yong'ancun Fm (Santonian) to Taipinglinchang Fm (Campanian) are confirmed. These research a-chievements indicate that the Upper Cretaceous-Paleocene in Jiayin can be well correlated to the strata in the neighboring Zeya-Bureja basin,Russia. The K--Pg boundary definited in Jiayin is the first well documented non-marine K--Pg boundary in China. Also the related paleoclimate,paleoenvironment and the mass extinctions in this area during the Cretaceous-Paleocene transition are also discussed. | Sun G. Akhmetiev M. Markevich V. Ashraf A. R. Bugdaeva E. Godefroit P. Bolotsky Yu. Dong Z. M. Golovneva L. Yang H. X. Sun C. L. Sun Y. W. Quan C. Kodrul T. Kezina T. Johnson K. Nishida H Dilcher D. L. Harding I. Chen Y. J. | 2011 | Global Geology2011，14，3： | 9 |
| 3 | 折叠式结石拦截器在经皮肾镜取石术中的应用显示文摘目的探讨折叠式结石拦截器在经皮肾镜取石术(PCNL)治疗’肾结石中的有效性和安全性。方法回顾分析108例行PCNL肾结石患者临床资料。术中应用折叠式结石拦截器56例,未应用52例。2组患者性别、年龄、结石大小比较差异均无统计学意义(P〉0.05)。比较2组在结石清除率、手术时间、术中出血量、住院天数和并发症等差异。结果2组结石清除率分别为94.6%(53/56)和82.7%(43/52),手术时间分别为112、142min,出血量为205、245ml,差异均有统计学意义(P〈0.05)。2组住院时间分别为2.8、3.0d,并发症发生率分别为16.1%(9/56)和15.4%(8/52),2组比较差异无统计学意义(P〉0.05)。结论折叠式结石拦截器使用简单、方便、安全,PCNI。术中能有效阻止结石碎片下滑进入输尿管,提高结石清除率、缩短手术时间、减少手术出血量、不增加手术并发症。 | 陆鸿海 李爱华 Demetrius H Bagley Steve Dong | 2011 | 中华泌尿外科杂志2011，32，1： | 7 |
| 4 | Three-dimensional structural changes in living hippocampal neurons imaged using magnetic AC mode atomic force microscopy.显示文摘 | Yunxu S Danying L Yanfang R Dong H Wanyun M | 2006 | 中国生物学文摘2006，20，9： | 7 |
| 5 | 查看详情显示文摘 | W C Huang H Y Tam P K A Wai X Y Dong H Ming J P Xie | | 中国物理快报(英文版)0，，： | 4 |
| 6 | 可卡因暴露通过miR-30C-5P/苹果酸酶1/活性氧通路升高血压和加强主动脉僵硬度显示文摘滥用可卡因可增加心血管病死亡和发病风险,然而,其中潜在的分子机制仍然未知。通过可卡因滥用小鼠模型,Zhu等发现重复注射可卡因可导致小鼠血压升高和主动脉僵硬度增加(主动脉中活性氧水平同时升高),这种现象类似于人类高血压中观察到的现象。 | 刘莉 叶鹏 Zhu W Wang H Wei J Sartor GC Bao MM Pierce CT Wahlestedt CR Dykxhoorn DM Dong C | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 7 | Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine显示文摘 | Xu Z Zheng H Law SL Dong So D Han Y Xue H | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 8 | Expressionmonitoring by hybridization to high-density oligonu-cleotide arrays显示文摘 | Lockhart DJ Dong H Byme MC | | 0，，： | 3 |
| 9 | 伴有CD10异常表达的套细胞淋巴瘤显示文摘 | Zanetto U Dong H Huang Y 樊祥山(摘译) | 2008 | 临床与实验病理学杂志2008，24，5： | 2 |
| 10 | Anaerobic bacteria and intrahepatic stones: detections of Clostridium sp. and Bacteroides fragilis显示文摘To detect anaerobic bacteria Clostridium sp . and Bacteroides fragilis in intrahepatic stones by molecular genetic method Methods DNA was extracted from 59 stone samples and subjected to polymerase chain reaction (PCR) amplification targeting the 16S rRNA gene of Clostridium sp . and the glutamine synthetase gene of Bacteroides fragilis Single-strand conformational polymorphism (SSCP) analysis was performed to identify the Clostridium sp Results 16S rRNA gene sequences for Clostridium sp. were identified in 49 stones (83%, 49/59) The two most common groups were detected in 19 (41%) and 17 (37%) of the 46 samples using SSPC analysis, and 25/59 (42%) stones were tested positive for Bacteroides fragilis Conclusions Anaerobes such as Clostridium sp and Bacteroides fragilis present in intrahepatic stones and may play a role in stone formation PCR is a useful technique to detect fastidious pathogens, which are difficult to culture SSCP of PCR products is a rapid method in differentiating bacterial | LIU Yanlei Kan Lam Yajarayma J Tang Paul H Gumerlock Dong Ki Lee Myung Hwa Kim Sum P Lee Joseph SilvaJr Joseph W Leung | 2000 | Chinese Medical Journal2000，，9： | 2 |
| 11 | Estimate of total CO2 output from desertified sandy land in China显示文摘 | Duan Z Xiao H Dong Z | 2001 | Atmospheric Environment2001，35，： | 2 |
| 12 | Identification and estimation of the biomass burning contribution to Beijing aerosol using levoglucosan as a molecular marker显示文摘 | Ting Zhang Magda Claeys Hélène Cachier Shuping Dong Wan Wang Willy Maenhaut Xiande Liu | 2008 | Atmospheric Environment2008，，29： | 2 |
| 13 | Six-dimensional potential energy surface of the dissociative chemisorption of HCl on Au(111) using neural networks显示文摘We constructed a six-dimensional potential energy surface(PES)for the dissociative chemisorption of HCl on Au(111)using the neural networks method based on roughly 70000 energies obtained from extensive density functional theory(DFT)calculations.The resulting PES is accurate and smooth,based on the small fitting errors and good agreement between the fitted PES and the direct DFT calculations.Time-dependent wave packet calculations show that the potential energy surface is very well converged with respect to the number of DFT data points,as well as to the fitting process.The dissociation probabilities of HCl initially in the ground rovibrational state from six-dimensional quantum dynamical calculations are quite diferent from the four-dimensional fixed-site calculations,indicating it is essential to perform full-dimensional quantum dynamical studies for the title molecule-surface interaction system. | LIU TianHui FU BiNa ZHANG Dong H | 2014 | Science China Chemistry2014，57，1： | 2 |
| 14 | Tea extraction methods in relation to control of epimerization of tea catechins 显示文摘 | Liang H L Liang Y R Dong J J | 2007 | Sci Food Agric2007，87，： | 1 |
| 15 | Electronic structure and optical properties of the Co-doped anatase TiO2 studied from first principles 显示文摘 | Weng H M Yang X P Dong J M | 2004 | Phys Rev2004，69，12： | 1 |
| 16 | Effect of Interracial Free Energy on Hydriding Reaction of Mg-Ni Thin Films 显示文摘 | Ouyang L Z Ye SY Dong H W | 2007 | ApplPhysLett2007，90，02： | 1 |
| 17 | A very simple and low cost route to Bi2 S3 nanorods bundles and dandelion-like nanostructures显示文摘 | Dong L H Chu Y Zhang W | 2008 | Mater Lett2008，62，27： | 1 |
| 18 | Costimulation,coinhibition and cancer显示文摘 | Inman B A Frigola X Dong H | 2007 | Curr Cancer Drug Targets2007，7，1： | 1 |
| 19 | Anodic electrosynthesis of cadmium selenide thin films-characterization and comparison with the passive/transpassive behavior of the CdX(X=S,Te) counterparts 显示文摘 | Kamal K Krishnan R | 1991 | J Electrchem Soc1991，138，1： | 1 |
| 20 | Co2Z type hexagonal ferrite prepared by sol-gel method显示文摘 | DONG W H YONG H H | 2006 | Mater Chem Phys2006，95，23： | 1 |
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