6篇
您的检索式：作者名="DONGYAN QIAO"
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| 1 | Chronological Link Between the Abrupt Change of the Loess Grain Size Sequence and the Formation of River Terraces on the Eastern Margin of the Qinghai-Tibetan Plateau Since the Late Early-Pleistocene显示文摘基于 magnetostratigraphy,磁性的危险性和 Garz | LIU Dongyan QIAO Yansong LI Weiran XIE Ruihuang PENG Shasha | 2011 | Acta Geologica Sinica(English Edition)2011，85，3： | 4 |
| 2 | Effects of Conjugated Linoleic Acid Levels and Feeding Intervals on Performance, Carcass Traits and Fatty Acid Composition of Finishing Barrows显示文摘 | Dongyan Sun Xiaoping Zhu Shiyan Qiao | 2004 | Archives of Animal Nutrition2004，58，4： | 1 |
| 3 | Preparation morpbology and mechamical properties of acrylatemodified polyurethane/unsaturated polyester resin graftIPNs显示文摘 | Tang Dongyan Qiao Yingjie Zhao Liancheng | | 0，，01： | 1 |
| 4 | The prevalence of hyperuricemia in a population of the coastal city of Qingdao, China 显示文摘 | Hairong N Qing Qiao Dongyan Hu | 2006 | J Rheumatol2006，33，7： | 1 |
| 5 | The prevalence of hyperuricemia in a population of the coastal city of Qingdao,China 显示文摘 | Hairong N Qing Qiao Dongyan Hu | 2006 | Rheumatol2006，33，： | 1 |
| 6 | Advanced glycation end-products change placental barrier function and tight junction in rats with gestational diabetes mellitus via the receptor for advanced glycation end products/nuclear factor-κB pathway显示文摘The placenta plays an important role in nutrient transport to maintain the growth and development of the embryo.Gestational diabetes mellitus(GDM),the most common complication during pregnancy,highly affects placental function in late gestation.Advanced glycation end-products(AGEs),a complex and heterogeneous group of compounds engaged by the receptor for AGEs(RAGE),are closely associated with diabetes-related complications.In this study,AGEs induced a decrease in the expression of tight junction(TJ)proteins in BeWo cells and increased the paracellular permeability of trophoblast cells by regulating RAGE/NF-κB.Sprague-Dawley(SD)rats injected with 100 mg/kg AGEs-rat serum albumin(RSA)via the tail vein from embryo day 2 were set as the placental barrier dysfunction model group(n=10).The effect of AGEs on placental permeability was determined using the Evans-Blue dye extravasation method.The ultrastructure of the placenta samples was observed by transmission electron microscopy.The effects of AGEs on the placenta were confirmed by treating rats with RAGE antagonist FPS-ZM1 and soluble forms of RAGE(sRAGE).AGEs treatment increased placental permeability and disrupted the tight junctions in pregnant rat placenta,but has no effect on blood glucose.The expression of TJ-related proteins,including ZO-1,Occludin,and Claudin 5,were downregulated after AGEs treatment.Further,AGEs treatment increased the expression of RAGE and nuclear factor-κB in the placenta of rats and upregulated the levels of vascular endothelial growth factor.The effects of AGEs on the placenta were blocked by RAGE antagonist FPS-ZM1 and sRAGE.This study demonstrates the mechanism underlying AGEs-induced disturbance in placental function in pregnant rats and highlights the potential of AGEs in the treatment of GDM. | YUEHUA SHI QIUYING YAN QIN LI WEI QIAN DONGYAN QIAO DONGDONG SUN HONG YU | 2023 | BIOCELL2023，47，1： | 0 |
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