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| 1 | Mental and physical symptoms associated with lower social support for patients with hepatitis C显示文摘AIM: To systematically examine the impact of the hepatitis C virus (HCV) diagnosis on patients' level of social support in a large-scale study. METHODS: Patients evaluated and treated for HCV in a tertiary referral center were enrolled in a cross-sectional study. Demographic data, functional and emotional status as measured by the Hospital Anxiety and Depression Scale (HAD) and the Sickness Impact Profile (SIP), severity of liver disease, mode of acquisition, and physical and psychiatric comorbidities were collected from patients or abstracted from the medical record. All participants completed a semi-structured interview, addressing questions of social support. RESULTS: A total of 342 patients (mean age 45.2 years; 37% women) were enrolled. Ninety-two (27%) patients described lower levels of support by family and friends. Nearly half of the participants (45%) noted the loss of at least one relationship due to the disease. Fears related to transmitting the disease (25%) were common and often associated with ignorance or even discrimination by others (19%). Nearly one fifth of the patients did not share information about their disease with others to avoid being stigmatized. Lower levels of social support were significantly associated with living alone, being unemployed, being excluded from antiviral therapy, having psychiatric comorbidities, contracting HCV through intravenous drug use, having high levels of anxiety and depression as measured by the HAD and negative mood state as measured by the SIP. Patients reporting lower levels of social support also noted more physical symptoms as measured by the SIP. CONCLUSION: Patients with hepatitis C often face significant social problems, ranging from social isolation to familial stress. The most common concerns reflect a limited insight of patients and their relatives and friends about the disease, the risk factors for its spread, and about potential consequences. Our data suggest that educational interventions targeting support persons and the stressors identified in our findings may lessen or alleviate the social strains patients with hepatitis C experience. | Julie A Blasiole Laura Shinkunas Douglas R LaBrecque Robert M Arnold Susan L Zickmund | 2006 | World Journal of Gastroenterology2006，12，29： | 5 |
| 2 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 2 |
| 3 | Difference in dietary intake between women with polycystic ovary syndrome and healthy controls 显示文摘 | Douglas C C Norris L E Oster R A | 2006 | Fertil Steril2006，86，2： | 1 |
| 4 | Health effects of recreational exposure to cyanobacteria(bluegreen algae) during recreational water-related activities显示文摘 | Pilotto L S Douglas R M Burch M D | 1997 | Australian and New Zealand Journal of Public Health1997，21，： | 1 |
| 5 | Crown profile models based on branch attributes in coastal Douglas-fir显示文摘 | RANDY L R DOUGLAS A M | 1997 | For Ecol and Manage1997，96，： | 1 |
| 6 | Cleaning up clostridium difficile infection显示文摘 | Matthew R T Scott C L Douglas R | 2002 | Mayo Clin Proc2002，76，9： | 1 |
| 7 | Isolation and characterization of multipotential mesenchymal stem cells from feline bone marrow显示文摘 | Douglas R Nancy R Terri L | 2002 | Arthritis Rheum2002，46，12： | 1 |
| 8 | Vascular Endothelial Growth Factor (VEGF) isoform expression and activity in human and murine lung injury显示文摘 | Medford A R L Douglas S K Godinho S I H | 2009 | Respiratory Research2009，10，1： | 1 |
| 9 | Electroantenno- gram responses of Hyles lineate (Sphingidae: Lepidoptera) to volatiles from Clarkia breweri (Onagraceae) and other moth-pollinated 显示文摘 | ROBERT A R DOUGLAS M L ERAN P | 1996 | Journal o{ Chemical Ecology1996，22，10： | 1 |
| 10 | Preparation and characterization of Pd-Cu composite membranes for hydrogen separation显示文摘 | Fernando R J Douglas W Robert L | 2003 | Chem Eng J2003，93，： | 1 |
| 11 | A Study of the Tribological Behaviour of Piston Ring/cylinder Liner Interaction in Diesel Engines Using Acoustic Emission显示文摘 | Douglas R M Steel J A Reuben R L | 2006 | Tribology International2006，39，： | 1 |
| 12 | Theme Article-Processing and Properties of Polymers Modified by Clays显示文摘 | Douglas L Hunter Karl W Kamena Paul D R | 2007 | MRS Bull2007，82，： | 1 |
| 13 | PUNCTATE VASCULAR EXPRESSION1 (PVE1)is a novel maize gene re- quired for leaf pattern formation that functions downstream of the ta-siARF pathway显示文摘 | Zhang X L Douglas R N Strable J | 2012 | Plant Physiol2012，159，： | 1 |
| 14 | Soil profile nitrate response to nitrogen fertilization of winter triticale显示文摘 | Nance Carasella D Lance R G Douglas L K | 2007 | Soil Sci Soc Am J2007，71，： | 1 |
| 15 | Winter triticale response to nitrogen fertilization when grown after corn or soybean显示文摘 | Gibson L R Carasella D N Douglas L K | 2007 | Agron J2007，99，： | 1 |
| 16 | On a stability theorem for nonlinear systems with slowly varying inputs 显示文摘 | DOUGLAS A L WILSON J R | 1990 | IEEE Trans on Automatic Control1990，35，7： | 1 |
| 17 | Herpes simplex virus type capsid protein VP26 interacts with dynein light chains RP3 and tctex1 and plays a role in retro grade cellular transport 显示文摘 | DOUGLAS M W DIEFENBACH R J HOMA F L | 2004 | J Biol Chem2004，279，28： | 1 |
| 18 | Isolation and characterization of multipotential mesenchymal stem cells from feline bone marrow 显示文摘 | Douglas R Nancy R Terri L | 2002 | Arthritis Rheum2002，46，12： | 1 |
| 19 | Prophylactic human papillomavirus vaccines显示文摘 | Douglas R L John T S | 2006 | J Clin Invest2006，116，： | 1 |
| 20 | Thiolactomycin and its analogues as novel anti-mycobacterial agents targeting KasA and KasB condesing enzymes in mycobacterium tuberculosis显示文摘 | Kremer L Douglas J D Baulard A R | 2000 | J Biol Chem2000，275，16： | 1 |
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