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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Clinical use of genotype to predict chemosensitivity in oligodendroglial tumors显示文摘 | Walker C Haylock B Husband D Joyce KA Fildes D Jenkirtson MD Smith T Broome J du Plessis DG Warnke PC | 2006 | 中国神经肿瘤杂志2006，4，3： | 2 |
| 3 | The possible role of hyyrogen sulfide on the pathogenesis of spontaneous hypertension in rats 显示文摘 | YAN H DU J TANG C | 2004 | Bioc hem Biophys Res Commun2004，313，1： | 2 |
| 4 | Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions显示文摘 | DU J WANG X MIERELES C etal | 2004 | J Clin Invest2004，113，1： | 1 |
| 5 | A quantitative screening of some xylose fermenting yeast isolates 显示文摘 | Du Preez J C Prior B A | 1985 | Biotechnol Lett1985，7，： | 1 |
| 6 | Prediction of beef eating qualities from colour, marbling and wavelet surface texture features using homogenous carcass treatment显示文摘 | Jackman P Sun D W Du C J P | 2009 | Pattern Recognition2009，42，5： | 1 |
| 7 | Phase transitions in reactive formation of Ti5Si3/TiAl in-situ composites显示文摘 | Du Y J Rao K P Chung J C Y | 2001 | Metallurgical and Materials Transactions A2001，3，： | 1 |
| 8 | Simultaneous production and recovery of fumaric acid from immobilized Rhizopus oryzae with a rotary biofilm contactor and an adsorption column 显示文摘 | Cao N J Du J X Gong C S | 1996 | Applied and Environmental Microbiology1996，62，8： | 1 |
| 9 | Accurate error- rate performance analysis of OFDM on frequency-se- lective Nakagami-m fading channels显示文摘 | DU Z CHENG J L BEAULIEU N C | 2006 | IEEE Trans Commun2006，54，2： | 1 |
| 10 | Achieving ultratine grain size in Mg-A1-Zn alloy by friction stir processing显示文摘 | CHANG C I DU X H HUANG J C | 2007 | Scripta Materialia2007，57，3： | 1 |
| 11 | β-Adrenergic receptors stimulate interleukin-6 production through Epac-dependent activation of PKCδ/p38 MAPK signalling in neonatal mouse cardiac fibroblasts显示文摘 | Chen C Du J Feng W | 2012 | Br J Pharmacol2012，166，2： | 1 |
| 12 | Numerical simulation of an advanced energy storage system using H2O-LiBr as working fluid(Ⅱ):System simulation and analysis显示文摘 | Xu S M Xu C H Zhang L Liang J Du R | | 0，，02： | 1 |
| 13 | Integration of an invertase gene to control sucrose metabolism in strawberry cultivars显示文摘 | Bachelier C Granam J Manoir J du et a1 | 1997 | Acta Horticul1997，439，： | 1 |
| 14 | Co-overexpression FIT with AtbHLH38 or AtbHLH39 in Ambidopsis-enhanced cadmium tolerance via increased cadmium sequestration in roots and improved iron homeostasis of shoots显示文摘 | Wu H L Chen C Du J | 2012 | Plant Physiology2012，158，2： | 1 |
| 15 | Transplanted adipose-derived stem cells ameliorate testicular dysfunction in a D-galactoseinduced aging rat model显示文摘 | Yang C Du Y Wang J | 2015 | Journal of Cellular Physiology2015，230，10： | 1 |
| 16 | Automatic measurement of pores and porosity in pork ham and their correlations with processing time, water content and texture显示文摘 | DU C J SUN D W | 2006 | Meat Science2006，72，2： | 1 |
| 17 | Urinary measurement of Na+/H+exchanger isoform 3(NHE3)protein as new marker of tubule injury in critically ill patients with ARF显示文摘 | du Cheyron D Daubin C Poggioli J | 2003 | Am J Kidney Dis2003，42，3： | 1 |
| 18 | Investigation on life span of Yuyi hairless mice显示文摘 | Du C Y Li H T Zhang J T | 2003 | J Zhengzhou Univ(Med Sci)2003，38，2： | 1 |
| 19 | Separation of Nickel and Calci- um by Solvent Extraction Using Mixtures of Carboxylic Acids and Alkylpyridines显示文摘 | Preston J S Du Preez A C | 2000 | Hydrometallurgy2000，58，3： | 1 |
| 20 | Preparation, microstructure and photocatalytic of the porous TiO2 anatase coating by Sol- Gel processing 显示文摘 | Yu J G Zhao X J Du J C | 2000 | Journal of Sol - Gel Science and Technology2000，17，： | 1 |
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