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| 1 | Spontaneous fungal peritonitis: Micro-organisms, management and mortality in liver cirrhosis-A systematic review显示文摘BACKGROUND Spontaneous peritonitis is an infection of ascitic fluid without a known intraabdominal source of infection. spontaneous fungal peritonitis (SFP) is a potentially fatal complication of decompensated cirrhosis, defined as fungal infection of ascitic fluid in the presence of ascitic neutrophil count of greater than 250 cells/mL. AIM To determine the prevalence of fungal pathogens, management and outcomes (mortality) of SFP in critically ill cirrhotic patients. METHODS Studies were identified using PubMed, EMBASE, Cochrane Central Register of Controlled Trials and Scopus databases until February 2019. Inclusion criteria included intervention trials and observation studies describing the association between SFP and cirrhosis. The primary outcome was in-hospital, 1-mo, and 6- mo mortality rates of SFP in cirrhotic patients. Secondary outcomes were fungal microorganisms identified and in hospital management by anti-fungal medications. The National Heart, Lung and Blood Institute quality assessment tools were used to assess internal validity and risk of bias for each included study. RESULTS Six observational studies were included in this systematic review. The overall quality of included studies was good. A meta-analysis of results could not be performed because of differences in reporting of outcomes and heterogeneity of the included studies. There were 82 patients with SFP described across all the included studies. Candida species, predominantly Candida albicans was the fungal pathogen in majority of the cases (48%-81.8%) followed by Candida krusei (15%- 25%) and Candida glabrata (6.66%-20%). Cryptococcus neoformans (53.3%) was the other major fungal pathogen. Antifungal therapy in SFP patients was utilized in 33.3% to 81.8% cases. The prevalence of in hospital mortality ranged from 33.3% to 100%, whereas 1-mo mortality ranged between 50% to 73.3%. CONCLUSION This systematic review suggests that SFP in end stage liver disease patient is associated with high mortality both in the hospital and at 1-mo, and that antifungal therapy is currently underutilized. | Tooba Tariq Furqan B Irfan Mehdi Farishta Brian Dykstra Eric Martin Sieloff Archita P Desai | 2019 | World Journal of Hepatology2019，11，7： | 7 |
| 2 | Effects of N-methyl-D- aspartate receptor antagonists on acute morphine-induced and I - methadone-induced antinociception in mice 显示文摘 | Fischer B D Carrigan K A Dykstra L A | 2005 | J Pain2005，6，7： | 1 |
| 3 | High-resolution video monitoring of hematopoietic stem cells cultured in single-cell arrays identifies new features of self-renewal显示文摘 | Dykstra B Ramunas J Kent D | 2006 | Proc Natl Acad Sci USA2006，103，21： | 1 |
| 4 | Development of an ultrasmall-pore micro-channel plate for space sciences application显示文摘 | LAPRADE B N DYKSTRA M W LANGEVIN F | 1996 | SPIE1996，2808，： | 1 |
| 5 | Quality of life and patient sati - sfaction: ESRD managed care demonstration 显示文摘 | Pifer T B Bragg - Gresham J L Dykstra D M | 2003 | Health Care Financing Review2003，24，4： | 1 |
| 6 | A mobile one-sided NMR sensor with a homogeneous magnetic field: The NMR-MOLE显示文摘 | Manz B Coy A Dykstra R | 2006 | J Magn Reson2006，183，1： | 1 |
| 7 | Interactions between an N- methly-D- asparte antagonist and low- efficacy opioid re- ceptor agonists in assays of schedule - controlled responding and thermal nociception显示文摘 | Fischer B D Dykstra L A | 2006 | J Pharmacol Exp Ther2006，318，： | 1 |
| 8 | ABC trans porter activities of murine hematopoietic stem cells vary ac cording to their developmental and activation status显示文摘 | UCHIDA N DYKSTRA B LYONS K | 2004 | Blood2004，103，12： | 1 |
| 9 | Anatomy of a submarine channel-levee:An example from Upper Cretaceous slope sediments,Rosario Formation,Baja California,Mexico显示文摘 | Kane I A Kneller B C Dykstra M | 2007 | Marine and Petroleum Geology2007，24，69： | 1 |
| 10 | ABC transporter activities of murine hematopoietic stem cells vary according to their developmental and activation status显示文摘 | Uchida N Dykstra B Lyons K | 2004 | Blood2004，103，12： | 1 |
| 11 | Anatomy of a submarine channel-levee:An example from Upper Cretaceous slope sediments,Rosario Formation,Baja California,Mexico显示文摘 | Kane I A Kneller B C Dykstra M | 2007 | Marine and Petroleum Geology2007，24，： | 1 |
| 12 | ABC transporter activities ofmurine hematopoietic stem cells vary according to their developmental and activation status显示文摘 | Uchida N Dykstra B Lyons K | 2004 | Blood2004，103，12： | 1 |
| 13 | ABC transporter activities of routine hematopoietic stem cells vary according to their developmental and activation status显示文摘 | Uchida N Dykstra B Lyons K | 2004 | Blood2004，103，12： | 1 |
| 14 | Effects of botulinum A toxin on detrusor-sphincter dyssynergia in spinal cord injury patients显示文摘 | Dykstra D D Sidi A A Scott A B | 1988 | Urol1988，139，5： | 1 |
| 15 | Effects of botulinum A toxin on detrusor-sphincter dyssynergia in spinal cord injury patients 显示文摘 | Dykstra D D Sidi A A Scott A B | 1988 | J Urol1988，139，5： | 1 |
| 16 | Interactions between an N-methly-D- asparle antagonist and low-efficacy opioid receptor agonists in assays of schedule-controlled responding and thermal nociception显示文摘 | Fischer B D Dykstra L A | 2006 | J PharmacolExpTher2006，318，3： | 1 |
| 17 | Anatomy of a submarine channel-levee: An example from Upper Cretaceous slope sediments, Rosario Formation, Baja California, Mexico 显示文摘 | Kane I A Kneller B C Dykstra M | 2007 | Marine and Petroleum Geology2007，24，69： | 1 |
| 18 | Effects of N-methyl-Daspartate receptor antagonists on acute morphine-induced and 1- methadone-induced antinociception in mice 显示文摘 | Fischer B D Carrigan K A Dykstra L A | 2005 | J Pain2005，6，7： | 1 |
| 19 | Interactions between an N-methly- D-asparte antagonist and low-efficacy opioid receptor agonists in assays of schedule-controlled respoinding and thermal nociception显示文摘 | FISCHER B D DYKSTRA L A | 2006 | J Pharmacol Exp Ther2006，318，7： | 1 |
| 20 | Interactions between an N-methly-Daspartate antagonist and low-efficacy opioid receptor agonists in assays of schedule-controlled responding and thermal nociception显示文摘 | Fisher B D Dykstra L A | 2006 | J Pharmacol Exp Ther2006，318，3： | 1 |
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