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| 1 | Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors显示文摘 | Jing Liao Zhao Wu Ying Wang Lu Cheng Chun Cui Yuan Gao Taotao Chen Lingjun Rao Siye Chen Nannan Jia Huiming Dai Shunmei Xin Jiuhong Kang Gang Pei Lei Xiao | 2008 | Cell Research2008，18，5： | 61 |
| 2 | Distribution of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in surface water and sediments from Baiyangdian Lake in North China显示文摘Persistent organochlorine compounds,including hexachlorocyclohexanes (HCHs),dichlorodiphenyltrichloroethanes (DDTs) and polychlorinated biphenyls (PCBs) were analyzed in surface water and sediments from Baiyangdian Lake,North China.Total concentrations of HCHs,DDTs and PCBs in surface water were in the range of 3.13-10.60,4.05-20.59 and 19.46-131.62 ng/L,respectively,and total concentrations of HCHs,DDTs and PCBs in sediments were 1.75-5.70,0.91-6.48 and 5.96-29.61 ng/g dry weight,respectively.Among the groups of HCHs (sum of α-HCH,β-HCH,γ-HCH and δ-HCH) and DDTs (sum of DDT,DDD and DDE),the predominance of β-HCH,DDE and DDD in water and sediment samples was clearly observed.This observation suggested that β-HCH was resistant to biodegradation and the DDTs had been transformed to its metabolites,DDE and DDD.For PCBs,penta-,hexa-and hepta-chlorinated congeners were the most abundant compounds in the both phases.Furthermore,the partitioning of chlorinated compounds between sediment and water was investigated to understand their transport and fates in aquatic ecosystems.The results indicated that average logs of organic carbon-normalized sediment-water partition coefficients (logK'oc) for OCPs varied between 3.20 and 5.53,and for PCBs,logK'oc values ranged from 3.19 to 5.57.The observed logK'oc was lower than their equilibrium logKoc predicted from linear model,which may be attributed to the solubility enhancement effect of colloidal matter in water phase and the disequilibrium between sediment and water. | Guohua Dai Xinhui Liu Gang Liang Xu Han Liu Shi Dengmiao Cheng Wenwen Gong | 2011 | Journal of Environmental Sciences2011，23，10： | 44 |
| 3 | OsCERK1-Mediated Chitin Perception and Immune Signaling Requires Receptor-like Cytoplasmic Kinase 185 to Activate an MAPK Cascade in Rice显示文摘保存联系病原体的分子的模式(PAMP ) 例如几丁质,被在激活 mitogen 的蛋白质 kinase (MAPK ) 的快速的激活串联的宿主细胞表面和扳机定位的模式识别受体(PRR ) 察觉,它为植物抵抗被要求到病原体。然而,到在植物的 MAPK 激活的从 PAMP 感觉的直接连接仍然保持大部分未知。在这研究,我们发现联系 PRR 的像受体的细胞质的 kinase Oryza sativa RLCK185 播送到通过和 MAPK kinase kinase 的相互作用表明串联的 MAPK 的从 PAMP 受体 OsCERK1 的有免疫力的发信号, OsMAPKKK,它是 MAPK 串联的起始的 kinase。OsRLCK185 交往与并且 phosphorylates OsMAPKKK 的 C 终端规章的领域。phosphomimetic OsRLCK185 和 OsMAPKKK 的 Coexpression 在 Nicotiana benthamiana 叶子激活 MAPK3/6 phosphorylation。而且, OsMAPKKK 交往与并且 phosphorylates OsMKK4,关键 MAPK kinase 那 transduces 几丁质信号。OsMAPKKK 的 Overexpression 增加导致几丁质的 MAPK3/6 激活,而 OsMAPKKK 击倒的妥协导致几丁质的 MAPK3/6 激活和抵抗到米饭强风真菌。一起拿,我们的结果在米饭从房间表面几丁质感觉建议一条发信号 phospho 小径的存在到 MAPK 串联的细胞内部的激活。 | Chao Wang Gang Wang Chi Zhang Pinkuan Zhu Huiling Dai Nan Yu Zuhua He Ling Xu Ertao Wang | 2017 | Molecular Plant2017，10，4： | 27 |
| 4 | Effects of sevoflurane preconditioning and postconditioning on rat myocardial stunning in ischemic reperfusion injury显示文摘Ischemic preconditioning and postconditioning distinctly attenuate ventricular arrhythmia after ischemia without affecting the severity of myocardial stunning. Therefore,we report the effects of sevoflurane preconditioning and postconditioning on stunned myocardium in isolated rat hearts. Isolated rat hearts were underwent 20 min of global ischemia and 40 min of reperfusion. After an equilibration period (20 min),the hearts in the preconditioning group were exposed to sevoflurane for 5 min and next washout for 5 min before ischemia. Hearts in the sevoflurane postconditioning group underwent equilibration and ischemia,followed immediately by sevoflurane exposure for the first 5 min of reperfusion. The control group received no treatment before and after ischemia. Left ventricular pressure,heart rate,coronary flow,electrocardiogram,and tissue histology were measured as variables of ventricular function and cellular injury,respectively. There was no significant difference in the duration of reperfusion ventricular ar-rhythmias between control and sevoflurane preconditioning group (P=0.195). The duration of reperfusion ventricular arrhythmias in the sevoflurane postconditioning group was significantly shorter than that in the other two groups (P<0.05). ±(dP/dt)max in the sevoflurane preconditioning group at 5,10,15,20,and 30 min after reperfusion was sig-nificantly higher than that in the control group (P<0.05),and there were no significant differences at 40 min after reperfusion among the three groups (P>0.05). As expected,for a 20-min general ischemia,infarct size in heart slices determined by 2,3,5-triphenyltetrazolium chloride staining among the groups was not obvious. Sevoflurane postcon-ditioning reduces reperfusion arrhythmias without affecting the severity of myocardial stunning. In contrast,sevoflu-rane preconditioning has no beneficial effects on reperfusion arrhythmias,but it is in favor of improving ventricular function and recovering myocardial stunning. Sevoflurane preconditioning and postconditioning may be useful for correcting the stunned myocardium. | An-lu DAI Li-hua FAN Feng-jiang ZHANG Mei-juan YANG Jing YU Jun-kuan WANG Tao FANG Gang CHEN Li-na YU Min YAN | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，4： | 19 |
| 5 | Efficacy of Atorvastatin combined with adipose-derived mesenchymal stem cell transplantation on cardiac function in rats with acute myocardial infarction显示文摘间充质的干细胞(MSC ) 广泛地被申请了在尖锐心肌的梗塞(AMI ) 以后的 cardiomyocytes 损失的恢复。然而,在 ischemic 心疾病的 MSC 的最佳的治疗学的功效被他们的差的幸存和低区分的率妨碍了。因此, MSC 幸存的改进和区分的率被保证并且为在 AMI 的 MSC 的功效批评。在这份报纸,从腹股沟的胖纸巾作为脂肪质导出被称为间充质的干细胞(ASC ) 的老鼠孤立的 MSC,和 ASC 的第四个段落被文化 co 在一个 transwell 系统与 cardiomyocytes 预先指定作为 co-ASCs 称为。十四天以后, GATA-4 (一个抄写因素) 和心脏的 troponin -- 我被细胞的 immunofluorescence 检测。Atorvastatin (Ator 组) 或车辆(控制组) 在老鼠在 AMI 生产以后为开始的 24 h 被管理。十四天以后,煽动性的参数和心脏的功能被评估。另外的幸存老鼠与 1 普物敭 ? 潴戠 ? 的一个总数被注射 ? 楤敲瑣琠牡敧 ? 敧敮漠 ? 業??? 祢攠桮湡散 ? 牧敥 ? 汦潵敲 ' 諟?牰瑯楥? 敲潰瑲牥攠灸牥浩湥吗? | Anping Cai Dongdan Zheng Yugang Dong Ruofeng Qiu Yuli Huang Yuanbin Song Zhigao Jiang Shaoqi Rao Xinxue Liao Jian Kuang Gang Dai Weiyi Mai | 2011 | Acta Biochimica et Biophysica Sinica2011，43，11： | 16 |
| 6 | Analysis of Atmospheric Boundary Layer Height Characteristics over the Arctic Ocean Using the Aircraft and GPS Soundings显示文摘Utilizing aircraft sounding data collected from the Surface Heat Budget of the Arctic Ocean (SHEBA, 1998) campaign, the authors evaluated commonly-used profile methods for Arctic ABL height estimation by validating against the'true'ABL height from aircraft sounding profiles, where ABL height is defined as the top of the layer with significant turbulence. Furthermore, the best performing method was used to estimate ABL height from the one-year GPS soundings obtained during SHEBA (October 1997-October 1998). It was found that the temperature gradient method produces a reliable estimate of ABL height. Additionally, the authors determined optimal threshold values of temperature gradient for stable boundary layer (SBL) and convective boundary layer (CBL) to be 6.5 K/100 m and 1.0 K/100 m, respectively. The maximum ABL height during the year was 1150 m occurred in May. Median values of Arctic ABL height in May, June, July, and August were 400 m, 430 m, 180 m, and 320 m, respectively. Arctic ABL heights are clearly higher in the spring than in the summer. | DAI Cheng-Ying GAO Zhi-Qiu WANG Qing CHENG Gang | 2011 | Atmospheric and Oceanic Science Letters2011，4，2： | 13 |
| 7 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 8 | Gastrin,somatostatin,and experimental disturbance of the gastrointestinal tract in rats显示文摘INTRODUCTIONThe field of gastrointestinal hormones has expanded at a dizzying rate[1-4].Gastrointestinal hormones as regulatory peptides that appear to be major components of bodily integration and have important regulatory actions on physioligical function of the gastrointestinal tract .The successful isolation of some gastrointestinal hormones and the development of sensitive methods for their detection have led to the unexpected finding that they also exist in the brain . | Yong Li Yao~1 Bo Xu~2 Wan Dai Zhang~1 Yu Gang Song~1 ~1Institute of Gastrointestinal Diseases,Nanfang Hospital,First Military Medical University,Guangzhou 510515,Guangdong Province,China ~2Department of Orthopedics Nanfang Hospital,First Military Medical University,Guangzhou 510515,Guangdong Province,ChinaYong Li Yao graduated from First Military Mcdical University with a master degree in 1998.She now works in the Institute of Gastrointestinal Diseases,Nanfang Hospital as a doctoral candidate majoring gastrointestinal diseases and gastrointestinal hormones,she has published 8 papers. | 2001 | World Journal of Gastroenterology2001，7，3： | 12 |
| 9 | Chromosome-Level Reference Genome and Population Genomic Analysis Provide Insights into the Evolution and Improvement of Domesticated Mulberry (Morns alba)显示文摘Mulberry(Morns spp.)is the sole plant consumed by the domesticated silkworm.However,the genome of domesticated mulberry has not yet been sequenced,and the ploidy level of this species remains unclear.Here,we report a high-quality,chromosome-level domesticated mulberry(Morus alba)genome.Analysis of genomic data and karyotype analyses confirmed that M.alba is a diploid with 28 chromosomes(2/7=2x=28).Population genomic analysis based on resequencing of 134 mulberry accessions classified domesticated mulberry into three geographical groups,namely,Taihu Basin of southeastern China(Hu mulberry),northern and southwestern China,and Japan.Hu mulberry had the lowest nucleotide diversity among these accessions and demonstrated obvious signatures of selection associated with environmental adaptation.Further phylogenetic analysis supports a previous proposal that multiple domesticated mulberry accessions previously classified as different species actually belong to one species.This study expands our understanding of genome evolution of the genus Morus and population structure of domesticated mulberry,which would facilitate mulberry breeding and improvement. | Feng Jiao Rongsong Luo Xuelei Dai Hui Liu Gang Yu Shuhua Han Xin Lu Chao Su Qi Chen Qinxia Song Caiting Meng Fanghong Li Hongmei Sun Rui Zhang Tian Hui Yonghua Qian Aichun Zhao Yu Jiang | 2020 | Molecular Plant2020，13，7： | 10 |
| 10 | Kinetics of iron removal from metallurgical grade silicon with pressure leaching显示文摘In this paper, the kinetics of pressure leaching for purification of metallurgical grade silicon with hydrochloric acid was investigated. The effects of particle size, temperature, total pressure, and concentration of hydrochloric acid on the kinetics and mechanism of iron removal were studied. It was found that the reaction kinetic model followed the shrinking core model, and the apparent activation energy of the leaching reaction was 46.908 kJ/mol. And the apparent reaction order of iron removal with pressure leaching was 0.899. The kinetic equation was ob-tained and the mathematical model of iron removal from metallurgical grade silicon (MG-Si) was given as follows: 1-2/3x-(1-x)2/3=exp(5.1654-4811.4591/T+1.287lnp+1.046ln[C])·t/r02· The values calculated from the equation were consistent with the experimental results. | YU Zhanliang XIE Keqiang MA Wenhui ZHOU Yang XIE Gang DAI Yongnian | 2011 | Rare Metals2011，30，6： | 9 |
| 11 | Rigid elliptical cross-section ogive-nose projectiles penetration into concrete targets显示文摘The elliptical cross-section ogive-nose projectile(ECOP) has recently attracted attention because it is well suited to the flattened shape of earth-penetrating weapons. However, the penetration performance of ECOPs has not been completely understood. The objective of this study was to investigate the penetration performance of ECOPs into concrete targets using a theoretical method. A general geometric model of ECOPs was introduced, and closed-form penetration equations were derived according to the dynamic cavity-expansion theory. The model was validated by comparing the predicted penetration depths with test data, and the maximum deviation was 15.8%. The increment in the penetration depth of the ECOP was evaluated using the proposed model, and the effect of the majoreminor axis ratio on the increment was examined. Additionally, the mechanism of the penetration-depth increment was investigated with respect to the caliber radius head, axial stress, and resistance. | Xiang-hui Dai Ke-hui Wang Ming-rui Li Jian Duan Bing-wen Qian Gang Zhou | 2021 | Defence Technology(防务技术)2021，17，3： | 9 |
| 12 | Population Genomic Analysis and De Novo Assembly Reveal the Origin of Weedy Rice as an Evolutionary Game显示文摘Crop weediness,especially that of weedy rice(Oryza sativa f.spontanea),remains mysterious.Weedy rice possesses robust ecological adaptability;however,how this strain originated and gradually formed proprietary genetic features remains unclear?Here,we demonstrate that weedy rice at Asian high latitudes(WRAH)is phylogenetically well defined and possesses unselected genomic characteristics in many divergence regions between weedy and cultivated rice.We also identified novel quantitative trait loci underlying weedy-specific traits,and revealed that a genome block on the end of chromosome 1 is associated with rice weediness.To identify the genomic modifications underlying weedy rice evolution,we generated the first de novo assembly of a high-quality weedy rice genome(WR04-6),and conducted a comparative genomics study between WR04-6 with other rice reference genomes.Multiple lines of evidence,including the results of demographic scenario comparisons,suggest that differentiation between weedy rice and cultivated rice was initiated by genetic improvement of cultivated rice and that the essence of weediness arose through semi-domestication.A plant height model further implied that the origin of WRAH can be modeled as an evolutionary game and indicated that strategy-based selection driven by fitness shaped its genomic diversity. | Jian Sun Dianrong Ma Liang Tang Minghui Zhao Guangchen Zhangh Wenjia Wang Jiayu Song Xiang Li Zimeng Liu Wenxing Zhang Quan Xu Yuncheng Zhou Jianzhong Wu Toshio Yamamoto Fei Dai Yan Lei Song Li Gang Zhou Hongkun Zheng Zhengjin Xu Wenfu Chen | 2019 | Molecular Plant2019，12，5： | 9 |
| 13 | Estimation of forest volumes by integrating Landsat TM imagery and forest inventory data显示文摘Accurate information about forest volumes is essential for forest management planning. The survey interval of the Forest Resource Inventory of China (FRIC) is too long to meet the demand for timely decision-making required for forest protection, management, and utilization. Analysis of satellite imagery provides good potential for more frequent reporting of forest parameters. In this study, we describe an application of the k-nearest neighbors (kNN) method to Landsat TM imagery for improving estimation of forest volumes. Several spectral features were tested and compared in forest volume estimations, including normalized difference vegetation index, environmental vegetation index, and the combination of the spectral features. The combined index resulted in the most accurate volume estimations. The kNN estimator and the combined index were then used in forest volume estimation. The estimation error (RMSE) of the total volume was44.2%, much lower than those for Larix forest (the RMSE was 51.7%) and those for the Korean pine and broadleaved forests (the estimation errors were over 71.7% and 88.19%,respectively). This preliminary study demonstrates the potential of forest volume estimations with remote sensing data to provide useful information for forest management if only limited ground information is available. | GU Huiyan, DAI Limin, WU Gang, XU Dong, WANG Shunzhong &WANG Hui Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China School of Forestry, Northeast Forestry University, Harbin 150040, China State Key Lab of Systems Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Graduate University of Chinese Academy of Sciences, Beijing 100039, China | 2006 | Science China(Technological Sciences)2006，49，z1： | 8 |
| 14 | Epidural Spinal Cord Stimulation Promotes Motor Functional Recovery by Enhancing Oligodendrocyte Survival and Differentiation and by Protecting Myelin after Spinal Cord Injury in Rats显示文摘Epidural spinal cord stimulation (ESCS) markedly improves motor and sensory function after spinal cord injury (SCI), but the underlying mechanisms are unclear.Here, we investigated whether ESCS affects oligodendrocyte differentiation and its cellular and molecular mechanisms in rats with SCI. ESCS improved hindlimb motor function at 7 days, 14 days, 21 days, and 28 days after SCI.ESCS also significantly increased the myelinated area at 28days, and reduced the number of apoptotic cells in the spinal white matter at 7 days. SCI decreased the expression of 20,30-cyclic-nucleotide 30-phosphodiesterase (CNPase,an oligodendrocyte marker) at 7 days and that of myelin basic protein at 28 days. ESCS significantly upregulated these markers and increased the percentage of Sox2/CNPase/DAPI-positive cells (newly differentiated oligodendrocytes) at 7 days. Recombinant human bone morphogenetic protein 4 (rh BMP4) markedly downregulated these factors after ESCS. Furthermore, ESCS significantly decreased BMP4 and p-Smad1/5/9 expression after SCI,and rh BMP4 reduced this effect of ESCS. These findings indicate that ESCS enhances the survival and differentiation of oligodendrocytes, protects myelin, and promotes motor functional recovery by inhibiting the BMP4-Smad1/5/9 signaling pathway after SCI. | Gang Li Zhong-Kai Fan Guang-Fei Gu Zhi-Qiang Jia Qiang-Qiang Zhang Jun-Yu Dai Shi-Sheng He | 2020 | Neuroscience Bulletin2020，36，4： | 8 |
| 15 | Diabetic macular edema in proliferative stage treated with anti-vascular endothelial growth factor agent and triamcinolone acetonide by laser-based strategies显示文摘AIM: To appraise the effect of treatment for diabetic macular edema(DME) in proliferative stage with sufficient panrentinal photocoagulation(PRP) therapy and intravitreal injections(IV) Conbercept and posterior subtenon's triamcinolone acetonide(STTA) sequential therapy.METHODS: This prospective clinical randomized controlled trial of cross-over design was conducted in three phases. The participants included cases of DME in proliferative stage. They were divided into two groups and treated with PRP before enrollment. Group A were treated with IVConbercept 0.5 mg for one month in the 1^(st) phase. Group B were treated with STTA 40 mg(twice per two weeks). The interventions were exchanged in the second phase(2mo) between the two groups. In the third phase(3-6mo) no other treatment was given. Best corrected visual acuity(BCVA), central macular thickness(CMT) measured by OCT and complications were compared.RESULTS: After phase I: in Group A, BCVA improved from 0.201±0.17 to 0.37±0.24(F=5.88, P=0.004). CMT changed from 449±155.10 to 304.1±84.70 μm(F=14.9, P<0.01). In Group B, BCVA changed from 0.195±0.19 to 0.26±0.20(F=0.76, P=0.41) while CMT changed from 463.82±152.92 to 366.00±115.40 μm(F=3.70, P<0.03). The improvement of BCVA was better in Group A(P<0.05). After phase II: in Group A, BCVA raised to 0.47±0.27(F=0.26, P<0.01), CMT reduced to 260.67±62.97 μm(F=-188.3, P<0.01); in Group B, BCVA raised to 0.51±0.26(F=0.31, P<0.01), CMT reduced to 261.93±50.15 μm(F=-201.9, P<0.01). But there were no difference between two groups(P>0.05). After phase III: in Group A, BCVA maintained 0.42±0.25(F=0.22, P=0.001), CMT maintained 267.8±58.34 μm,(F=-0.27, P<0.01); in Group B, BCVA was 0.47±0.25(F=-0.27, P<0.01), CMT was 272.71±49.16 μm(F=-191.1, P<0.01). No serious complications happened in all phases.CONCLUSION: PRP+Conbercept is better than PRP+STTA in DME with proliferative stage but PRP+Conbercept+STTA sequential therapy may be a wiser choice for persistent effectiveness on anatomical as well as functional status. | Gang Qiao Wan-Jiang Dong Yan Dai Zhen-Hua Jiang Hai-Ke Guo | 2017 | International Journal of Ophthalmology(English edition)2017，10，7： | 7 |
| 16 | Sub-threshold micro-pulse diode laser treatment in diabetic macular edema: a Meta-analysis of randomized controlled trials显示文摘AIM:To examine possible differences in clinical outcomes between sub-threshold micro-pulse diode laser photocoagulation(SDM) and traditional modified Early Treatment Diabetic Retinopathy Study(mETDRS)treatment protocol in diabetic macuiar edema(DME).METHODS:A comprehensive literature search using the Cochrane Collaboration methodology to identify RCTs comparing SDM with mETDRS for DME.The participants were type Ⅰ or type Ⅱ diabetes mellitus with clinically significant macuiar edema treated by SDM from previously reported randomized controlled trials(RCTs).The primary outcome measures were the changes in the best corrected visual acuity(BCVA) and the central macuiar thickness(CMT) as measured by optical coherence tomography(OCT).The secondary outcomes were the contrast sensitivity and the damages of the retina.RESULTS:Seven studies were identified and analyzed for comparing SDM(215 eyes) with mETDRS(210 eyes)for DME.There were no statistical differences in the BCVA after treatment between the SDM and mETDRS based on the follow-up:3mo(MD,-0.02;95% Cl,-0.12 to 0.09;P=0.77),6mo(MD,-0.02;95% Cl,-0.12 to 0.09;P=0.75),12mo(MD,-0.05;95% Cl,-0.17 to 0.07;P=0.40).Likewise,there were no statistical differences in the CMT after treatment between the SDM and mETDRS in 3mo(MD,-9.92;95% Cl,-28.69 to 8.85;P=0.30),6mo(MD,-11.37;95% Cl,-29.65 to 6.91;P=0.22),12mo(MD,8.44;95% Cl,-29.89 to 46.77;P=0.67).Three RCTs suggested that SDM laser results in good preservation of contrast sensitivity as mETDRS,in two different followup evaluations:3mo(MD,0.05;95% Cl,0 to 0.09;P=0.04) and 6mo(MD,0.02;95% Cl,-0.10 to 0.14;P=0.78).Two RCTs showed that the SDM laser treatment did less retinal damage than that mETDRS did(OR,0.05;95% Cl,0.02 to 0.13;P<0.01).CONCLUSION:SDM laser photocoagulation shows an equally good effect on visual acuity,contrast sensitivity,and reduction of DME as compared to conventional mETDRS protocol with less retinal damage. | Gang Qiao Hai-Ke Guo Yan Dai Xiao-Li Wang Qian-Li Meng Hui Li Xiang-Hui Chen Zhong-Lun Chen | 2016 | International Journal of Ophthalmology(English edition)2016，9，7： | 7 |
| 17 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 18 | Intraoperative microvascular Doppler monitoring in intracranial aneurysm surgery显示文摘 | HUI Pin-jing YAN Yan-hong ZHANG Shi-ming WANG Zhong YU Zheng-quan ZHOU You-xin LI Xiang-dong CUI Gang ZHOU Dai HUI Guo-zhen LAN Qing | 2013 | Chinese Medical Journal2013，，13： | 6 |
| 19 | Negative pressure catheter drainage and jejunal feeding for descending necrotizing mediastinitis by interventional techniques:a retrospective study显示文摘Purpose: Descending necrotizing mediastinitis(DNM) is a lethal and acute suppurative disease. This report aimed to summarize our experience in the treatment of DNM with continuous negative pressure catheter drainage and transnasal jejunal feeding by interventional techniques. Materials and Methods: We retrospectively analyzed relevant clinical data of patients with DNM who underwent continuous negative pressure catheter drainage and transnasal jejunal feeding. All drainage catheters and jejunal feeding tubes were inserte d by interventional techniques. Results: In total, 21 patients were diagnosed with DNM by esophagography and computed tomography(CT). Catheters for the drainage of mediastinal abscesses as well as transnasal jejunal feeding tubes were successfully placed in all patients, indicating a 100% success rate. Of all patients, 13 underwent insertion of abscess drainage catheters through percutaneous puncture under DynaCT guidance, while eight had drainage catheter insertion through fistula orifices in the posterior nasopharyngeal wall or esophagus under fluoroscopic guidance. In total, 26 drainage tubes were inserted. One patient with diabetes died of sepsis and diabetic ketoacidosis 5 days postoperatively, while the remaining 20 patients showed good recovery with successful removal of the drainage catheters. Durations of catheterization were 45.2±50.44 days. The overall clinical success rate was 95.2%. Conclusion: The above described methods are non-surgical, minimally invasive and efficacious, and may be alternative therapeutic tools for patients who are not eligible for surgical operation, have a high postoperative risk, or are more likely to choose minimally invasive techniques. | Gang Wu Meipan Yin Yi Fang Gang Liu Yonggang Luo Weihong Xie Yaozhang Dai Jin Shi Xinwei Han | 2018 | Journal of Interventional Medicine2018，1，2： | 6 |
| 20 | Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy显示文摘Aescin, a natural mixture of triterpene saponins, has been reported to exert anticancer effect. Recent studies show that aescin increases intracellular reactive oxygen species (ROS) levels. However, whether the increased ROS play a role in the anticancer action of aescin remains to be explored. In this study, we demonstrated that aescin (20-80 μg/mL) dose-dependently induced apoptosis and activated mammalian target of rapamycin (mTOR)-independent autophagy in human hepatocellular carcinoma HepG2 cells and colon carcinoma HCT 116 cells. The activation of autophagy favored cancer cell survival in response to aescin, as suppression of autophagy with ATG5 siRNAs or 3-methyladenine (3-MA), a selective inhibitor of autophagy, promoted aescin-induced apoptosis in vitro, and significantly enhanced the anticancer effect of aescin in vivo. Meanwhile, aescin dose-dependently elevated intracellular ROS levels and activated Ataxia-telangiectasia mutated kinase/AMP-activated protein kinase/UNC-51-like kinase-1 (ATM/AMPK/ULK1) pathway. The ROS and ATM/AMPK/ULK1 pathway were upstream modulators of the aescin-induced autophagy, as N-acetyl-L-cysteine (NAC) or ATM kinase inhibitor (KU-55933) remarkably suppressed aescin-induced autophagy and consequently promoted aescin-induced apoptosis, whereas overexpression of ATG5 partly attenuated NAC-induced enhancement in aescin-induced apoptosis. In conclusion, this study provides new insights into the roles of aescin-mediated oxidative stress and autophagy in cancer cell survival. Our results suggest that combined administration of the antioxidants or autophagic inhibitors with aescin might be a potential strategy to enhance the anticancer effect of aescin. | Bin Li Guo-liang Wu Wei Dai Gang Wang Hao-yuan Su Xue-ping Shen Rui Zhan Jia-ming Xie Zhong Wang Zheng-hong Qin Quan-gen Gao Gen-hai Shen | 2018 | Acta Pharmacologica Sinica2018，39，12： | 5 |
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