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| 1 | A Pilot Study on the Noninvasive Evaluation of Intestinal Damage in Celiac Disease Using I-FABP and L-FABP显示文摘 | Joep P. M. Derikx Anita C. E. Vreugdenhil Anita M. Van den Neucker Joep Grootjans Annemarie A. van Bijnen Jan G. M. C. Damoiseaux L. W. Ernest van Heurn Erik Heineman Wim A. Buurman | 2009 | Journal of Clinical Gastroenterology2009，，8： | 2 |
| 2 | Atomic force microscopy correlates antimetastatic potentials of HepG2 cell line with its redox/energy status: effects of curcumin and Khaya senegalensis显示文摘OBJECTIVE: The fatality of cancer is mostly dependent on the possibility of occurrence of metastasis. Thus, if the development of metastasis can be prevented through novel therapeutic strategies targeted against this process, then the success of cancer treatment will drastically increase. In this study, therefore, we evaluated the antimetastatic potentials of an extract of Khaya senegalensis and curcumin on the metastatic liver cell line HepG2, and also assessed the anticancer property of the extract.METHODS: Cells were cultured and treated with graded concentrations of test substances for 24, 48, or 72 h with provisions made for negative controls. Treated cells were assessed as follows: nanotechnologically—atomic force microscopy(AFM) was used to determine cell stiffness; biochemically—cell cytotoxicity, glutathione level and adenosine triphosphate status, caspase activation and mitochondrial toxicity were considered; and microbiologically—a carrot disk assay was used to assess the anticancer property of the extract of K. senegalensis.RESULTS: Curcumin and K. senegalensis increased the cell stiffness by 2.6-and 4.0-fold respectively, indicating their antimetastatic effects. Corresponding changes in redox(glutathione level) and energy(adenosine triphosphate) status of the cells were also demonstrated. Further mechanistic studies indicated that curcumin was not mitotoxic in HepG2 cells unlike the K. senegalensis extract. In addition, the extract potently inhibited the Agrobacterium tumefaciens-induced genetic transformation based on carrot disk assay.CONCLUSION: Cell elasticity measurement data, using AFM, strongly suggested, for the first time, that both curcumin and the extract of K. senegalensis exhibited antimetastatic properties on HepG2 cells. | Jeremiah Olorunjuwon Olugbami Robert Damoiseaux Bryan France Michael A. Gbadegesin Adam Z. Stieg Shivani Sharma Oyeronke A. Odunola James K. Gimzewski | 2017 | Journal of Integrative Medicine2017，15，3： | 2 |
| 3 | Combining shape andconnectivity analysis:an MRI study of thalamic degeneration inAlzheimer’s disease显示文摘 | Zarei M Patenaude B Damoiseaux J | 2010 | Neuroimage2010，49，1： | 1 |
| 4 | Cytokines inexhaled breath condensate of children with asthma and cystic fibrosis显示文摘 | Robroeks C M Jobsis Q Damoiseaux J G M C | 2006 | Ann Allergy Asthma Immunol2006，96，2： | 1 |
| 5 | Reduced resting state brain activity in the default network in normal aging显示文摘 | Damoiseaux JS Becknmnn CF Arigita EJ | 2008 | Cereb Cortex2008，18，8： | 1 |
| 6 | Evaluation of a new fluorescent-enzyme immuno-assay for diagnosis and follow-up of ANCA-associated vasculitis显示文摘 | Damoiseaux JG Slot MC Vaessen M | 2005 | J Clin Immunol2005，25，3： | 1 |
| 7 | Consistent resting-state networks across healthy subjeets显示文摘 | Damoiseaux JS Rombouts S Barkhof F | 2006 | Proe NatlAcad Sci U S A2006，103，13： | 1 |
| 8 | Evaluation of a novel line-blot immunoassay for the detection of antibodies to extract- able nuclear antigens显示文摘 | Damoiseaux J Boesten K Giesen J | 2005 | Ann N Y Acad Sci2005，26，3： | 1 |
| 9 | Consistent resting-state networks across healthy subjects显示文摘 | Damoiseaux JS Rombouts SA Barkhof F | | 0，，： | 1 |
| 10 | Vascular inflammation in cerebral small vessel disease显示文摘 | Rouhl RP Damoiseaux JG Lodder J | 2012 | Neurobiol Aging2012，33，16： | 1 |
| 11 | Evaluation of a novel line-blot immunoassay for the detection of antibod- ies to extractable nuclear antigens显示文摘 | Damoiseaux J Boesten K Giesen J | 2005 | Ann NY Aead Sci2005，1050，8： | 1 |
| 12 | Evaluation of a novel line-blot immunoassay for the detection of antibodies to extractable nuclear antigens显示文摘 | Damoiseaux J Boesten K Giesen J | 2005 | Ann N~ Acad Sci2005，1050，： | 1 |
| 13 | Costimulatory molecules CD80 and CD86 in the rat tissue distribution and expression by antigen-presenting cells 显示文摘 | Yagita H Okumura K | 1998 | J Leukoc Biol1998，64，6： | 1 |
| 14 | Pulmonary function and inflammatory markers in patients undergoing coronary revascularisation with or without cardiopulmonary bypass显示文摘 | Heijmans JH Liem KS Damoiseaux GM | 2007 | Anaesthesia2007，62，12： | 1 |
| 15 | T cells in ANCAassociatedvasculitis: what can we learn from lesional versuscirculating T cells-显示文摘 | Wilde B Thewissen M Damoiseaux J | 2010 | Arthritis Res Ther2010，12，1： | 1 |
| 16 | The influence of sex hormones on cytokines in multiple sclerosis and experimental autoimmune encephalomyelitis: a review显示文摘 | van den Broek HH Damoiseaux JG De Baets MH | 2005 | Mult Scler2005，11，3： | 1 |
| 17 | Seeing the light:luminescent re- porter gene assays显示文摘 | Miraglia LJ King FJ Damoiseaux R | 2011 | Comb Chem High Throughput Screen2011，14，8： | 1 |
| 18 | Regional white matter integrity differentiates between vascular dementia and Alzheimer disease显示文摘 | Zarei M Damoiseaux JS Morgese C | 2009 | Stroke2009，40，： | 1 |
| 19 | Association study on two vitamin D receptor gene polymorphisms and vitamin D metabolites in multiple sclerosis显示文摘 | Smolders J Damoiseaux J Menheere P | | 0，，： | 1 |
| 20 | Consistent resting state networks across healthy subjects显示文摘 | Damoiseaux JS Rombouts SARB Barkhof F | | 0，，： | 1 |
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