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| 1 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 2 | Pair Box 8 ( PAX8 ) protein expression in high grade, late stage ( stage III And 1V ) ovarian serous carcinoma显示文摘 | Paulette M F Dan W Damanzoopinder S | 2012 | Gynecol Onco}2012，127，1： | 1 |
| 3 | Isozyme inheritance and variation in Actindia显示文摘 | Huang H W Dan F Wang Z | 1997 | Heredity1997，78，： | 1 |
| 4 | The ring-opening polymerization of D,L-lactide in the melt initiated with tetra- phenyltin 显示文摘 | KOHN F E WAN DEN BERG J W A DAN DE RIDDER G | 1984 | Journal of Applied Polymer Science1984，29，12： | 1 |
| 5 | ORFH79 impairs mitochondrial function via interaction with a subunit of electron transport chain complex II1 in Honglian 显示文摘 | Wang K Gao F Ji Y X Liu Y Dan Z W Yang P F Zhu Y G Li S Q | 2013 | New Phytologist2013，198，2： | 1 |
| 6 | Molecular cloning and expression analysis of interferon-gamma-indueible-lysosomal thiol reductase gene in orange-spotted grouper, Epinephelus coioides 显示文摘 | Dan W B Ren F Zhang C | 2007 | Fish & Shellfish Immunology2007，23，6： | 1 |
| 7 | 显示文摘 | Dan Z G Ni H W Xu B F | 2005 | Thin Solid Films2005，492，： | 1 |
| 8 | Microstructure and antibacterial properties of AISI 420 stainless steel implanted by copper ions显示文摘 | Dan Z G Ni H W Xu B F | 2005 | Thin Solid Films2005，，492： | 1 |
| 9 | Novel magnetic porous carbon spheres derived from chelating resin as a heterogeneous Fenton catalyst for the removal of methylene blue from aqueous solution 显示文摘 | Ma J J Zhou L C Dan W F | 2015 | Journal of Colloid and Interface Science2015，446，： | 1 |
| 10 | Cardiac mast cells regulate myocyte ANP release via histamine H2 receptor in beating rabbit atria显示文摘 | DAN L JIN F W JING Y J | 2009 | Regul Pept2009，155，13： | 1 |
| 11 | Microstructure and antibacterlal properties of AISI 420 stainless steel implanted by copper ions显示文摘 | Dan Z G Ni H W Xu B F | 2005 | Thin Solid Films2005，492，： | 1 |
| 12 | Quantitative Analysis of the Marker Compounds in Salvia miltiorrihiza Root and Its Phytomedieinal Preparations 显示文摘 | DAN Y YING N P WEN W F | 2005 | Chem Pharm Bull2005，53，5： | 1 |
| 13 | Cardiac mast cells regulate myocyte ANP release via histamine H2 receptor in beating rabbit atria 显示文摘 | DAN L JIN F W JING Y J | 2009 | Regulatory Peptides2009，155，13： | 1 |
| 14 | Porous carbon and carbon/metal oxide microfibers with well-controlled pore structure and interface显示文摘 | Qihui Shi Hongjun L Dan F Jianfang W | 2008 | J AM CHEM SOC2008，130，： | 1 |
| 15 | A novel protonconductive membrane with reduced methanol permeability prepared from bromometh- ylated poly(2,6-dimethyl-1,4-phenylene oxide) (BPPO) 显示文摘 | Dan W Rongqiang F | 2008 | Journal of Membrane Science2008，310，： | 1 |
| 16 | Pair Box 8(PAX8)protein expression in high grade,late stage(stage Ⅲ and Ⅳ)ovarian serous carcinoma显示文摘 | Paulette M F Dan W Damanzoopinder S | 2012 | Gynecol Oncol2012，127，1： | 1 |
| 17 | Effects of shear strength reduction strategies on safety factor of homogeneous slope based on a general nonlinear failure criterion显示文摘 | Zhao L Yang F Zhang Y Dan H Liu W | 2015 | Computers and Geotechnics2015，63，21： | 1 |
| 18 | Microstructure and Antibacterial Properties of AISI 420 Stainless Steel Implanted by Copper Ions显示文摘 | Dan Z G Ni H W Xu B F | 2005 | Thin Solid Films2005，，492： | 1 |
| 19 | Preference semantics,Ⅲ-formedness,and metaphor显示文摘 | DAN F YORICK W | 1983 | American Journal of Computational Linguistics1983，9，34： | 1 |
| 20 | Pomegranate husk extract, punicalagin and ellagic acid inhibit fatty acid synthase and adipogenesis of 3T3-L1 adipocyte显示文摘 | DAN W MA X F TIAN W X | 2013 | Journal of Functional Foods2013，5，2： | 1 |
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