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| 1 | Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients显示文摘AIM: To determine the prevalence of hepatitis B virus (HBV) in adult human immunodeficiency virus (HIV) patients with CD4+ T-cell count less than 500/mm 3 and without antiretroviral therapy; to describe different HBV-HIV coinfection virological profiles; and to search for factors associated with HBs antigen (HBsAg) presence in these HIV positive patients.METHODS: During four months (June through September 2006), 491 patients were received in four HIV positive monitoring clinical centers in Abidjan. Inclusion criteria: HIV-1 or HIV-1 and 2 positive patients, age ≥ 18 years, CD4+ T-cell count < 500/mL and formal and signed consent of the patient. Realized blood tests included HIV serology, CD4+ T-cell count, quantitative HIV RNA load and HBV serological markers, such as HBsAg and HBc antibody (anti-HBcAb). We performed HBeAg, anti-HBe antibody (anti-HBeAb), anti-HBc IgM and quantitative HBV DNA load in HBsAg positive patients. Anti-HBsAb had been tested in HIV patients with HBsAg negative and anti-HBcAb-positive. HBV DNA was also tested in 188 anti-HBcAb positive patients with HBsAg negative status and without anti-HBsAb. Univariate analysis (Pearsonχ 2 test or Fischer exact test) and multivariate analysis (backward step-wise selection logistic regression) were performed as statistical analysis. RESULTS: Mean age of 491 patients was 36 ± 8.68 years and 73.3% were female. Type-1 HIV was found in 97% and dual-type HIV (type 1 plus type 2) in 3%. World Health Organization (WHO) clinical stage was 1, 2, 3 and 4 respectively in 61 (12.4%), 233 (47.5%), 172 (35%) and 25 patients (5.1%). Median CD4+ T-cell count was 341/mm 3 (interquartile range: 221-470). One hundred and twelve patients had less than 200 CD4+ T-cell/mm 3 . Plasma HIV-1 RNA load was elevated (≥ 5 log 10 copies/mL) in 221 patients (45%). HBsAg and anti-HBcAb prevalence was respectively 13.4% and 72.9%. Of the 66 HBsAg positive patients, 22 were inactive HBV carriers (33.3%), 21 had HBeAg positive hepatitis (31.8%) and 20 had HBeAg negative hepatitis (30.3%). HBeAg and anti-HBeAb were indeterminate in 3 of them. Occult B infection prevalence (HBsAg negative, anti-HBcAb positive, anti-HBsAb negative and detectable HBV DNA) was 21.3%. Three parameters were significantly associated with the presence of HBsAg: male [odds ratio (OR): 2.2;P = 0.005; 95% confidence interval (CI): 1.3-3.8]; WHO stage 4 (OR: 3.2;P = 0.01;95% CI: 1.3-7.9); and aspartate aminotransferase (AST) level higher than the standard (OR: 1.9;P = 0.04; 95% CI: 1.02-3.8). CONCLUSION: HBV infection prevalence is high in HIV-positive patients. HBeAg positive chronic hepatitis and occult HBV infection are more frequent in HIVpositive patients than in HIV negative ones. Parameters associated with HBsAg positivity were male gender, AIDS status and increased AST level. | Koffi Alain Attia Serge Eholié Eugène Messou Christine Danel Sandrine Polneau Henri Chenal Thomas Toni Myreille Mbamy Catherine Seyler Naomi Wakasugi Thérèse N'dri-Yoman Xavier Anglaret | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 2 | Monitoring and balance of gas flow in underground gas storage显示文摘 | Danel R Otte L | 2013 | Procedia earth and planetary science2013，，6： | 1 |
| 3 | Pulmonary alveolar pro- teinosis 显示文摘 | Boric R Danel C Debray MP | 2011 | Eur Reapir Rev2011，20，120： | 1 |
| 4 | Inflationary Bibliometric Val-ues :The Role of Scientific Collaboration and the Need for Rela-tive Indicators in Evaluative studies显示文摘 | Persson Ot Glanzel W Danell R | 2004 | Scientometrics2004，60，3： | 1 |
| 5 | Pulmonary alveolar proteinosis 显示文摘 | Borie R Danel C Debray M P | 2011 | Eur Respir Rev2011，20，120： | 1 |
| 6 | Refinements to the diastereoisomer-specific method for the anal-ysis of hexabromocyclododecane, Rapid Commun显示文摘 | TOMMY G T HALLDORSON T DANELL R | 2005 | Mass Spectrom2005，19，： | 1 |
| 7 | A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa 显示文摘 | Danel C Moh R Gabillard D | 2015 | N Engl J Med2015，373，9： | 1 |
| 8 | Association of CK19 mRNA detection of occult cancer cells in mediastinal lymph nodes in no-small cell lung carcinoma and high risk of early recurrence显示文摘 | Pimpec-Barthes FL Danel C Lacave R | 2005 | Eur J Cancer2005，41，2： | 1 |
| 9 | The decline of Swedish neuroscience- decomposing a bibliometric national science indicator显示文摘 | Glanzel W Danell R Persson O | 2003 | Scientometrics2003，57，2： | 1 |
| 10 | A carbohydrate side chain on hemagglutinins of Hong Kong influenza viruses inhibits recognition by a monoclonal antibody显示文摘 | Skehel J J Stevens D J Danels R S | 1984 | Proc Natl Acad Sci1984，81，： | 1 |
| 11 | Regional R&D Activities and Interaction in the Swedish Triple Helix显示文摘 | Danell R Persson O | 2003 | Scientometrics2003，58，2： | 1 |
| 12 | Pulmonary alveolar proteinosis 显示文摘 | Borie R Danel C Debray MP | 2011 | Eur Respir Rev2011，20，120： | 1 |
| 13 | Bioaccumulation and trophic transfer of some brominated flame retardants in a Lake Winnipeg(Canada)food web显示文摘 | Law K Hal dorson T Danel R | 2006 | Environmental Toxicology Chemistry2006，25，： | 1 |
| 14 | A trial of early anti- retrovirals and isoniazid preventive therapy in Africa显示文摘 | DANEL C MOH R GABILLARD D | 2015 | N Engl j med2015，373，9： | 1 |
| 15 | Association of CK19 mRNA detection of occult cancer cells in mediastinal lymph nodes in non-small cell lung carcinoma and high risk of early recurrence显示文摘 | Le Pimpec-Barthes F Danel C Lacave R | 2005 | Eur J Cancer2005，41，2： | 1 |
| 16 | Bioaccumulationand trophic transfer of some brominated flame retard-ants in a Lake Winnqjeg (Canada) food web 显示文摘 | Law K Halldorson T Danell R | 2006 | Envi-ronmental Toxicology and Chemistry2006，25，8： | 1 |
| 17 | Structure-antioxidant efficiency relationships of phenolic compounds and their contribution to the antioxidant activity of sea buckthorn juice显示文摘 | Danel R Meike B Dietrich K | 2003 | J Agric Food Chem2003，51，： | 1 |
| 18 | Pulmonary alveolar proteinosis显示文摘 | Borie R Danel C Debray M P | 2011 | Eur Respir Rev2011，20，120： | 1 |
| 19 | Pulmonary Alveolar Proteinosis显示文摘 | Borie R Danel C Debray M | 2011 | Eur Respir Rev2011，20，120： | 1 |
| 20 | Slope Stability of Geosynthetic Clay Liner Test Plots显示文摘 | Danel E D Koerner M R Rudolph B | 1998 | Journal of Geotechnical and Geoenvironmental Engineering1998，，7： | 1 |
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